Prunes May Blunt Adverse Effects of Oral Contraceptives on Bone Health in Young Adult Women: A Randomized Clinical Trial

IF 3.8 Q2 NUTRITION & DIETETICS Current Developments in Nutrition Pub Date : 2024-09-01 DOI:10.1016/j.cdnut.2024.104417
Taylor DeMasi, Michelle Tsang, Jenna Mueller, Kristine Giltvedt, Thuy Ngoc Nguyen, Mark Kern, Shirin Hooshmand
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Abstract

Background

Oral contraceptives (OCs) may promote bone loss, thereby leading to suboptimal bone health later in life. Research is needed to determine whether dietary interventions can blunt OC-related bone loss; prune consumption, shown to be effective in improving bone density in previous studies, could provide a safe and inexpensive solution.

Objectives

The purpose of this study was to determine whether 12 mo of consuming 50 g of prunes daily would prevent bone loss or increase bone accrual in young (18–25 y) OC users.

Methods

Ninety women were randomly assigned to a control group not using OCs (non-OC), an OC group not consuming prunes (OC), and an OC group consuming 50 g prunes daily (OC+P) for 12 mo. Bone mineral density (BMD) was measured at baseline and after 12 mo via dual-energy X-ray absorptiometry (at all sites) and peripheral quantitative computed tomography (at tibia). Blood samples were collected at baseline and after 6 and 12 mo to assess biomarkers.

Results

There were no significant differences between groups for dietary intake, physical activity, serum tartrate-resistant acid phosphatase-5b, or bone alkaline phosphatase concentrations. Baseline serum C-reactive protein and vitamin D concentrations were higher (P < 0.001) for OC and OC+P groups than those in the non-OC group. Serum parathyroid hormone was higher for non-OC group than OC group at both baseline (P = 0.049) and final (P = 0.032). BMD measured by dual-energy X-ray absorptiometry at all sites did not change among groups. Ultradistal radius BMD increased over time (P < 0.05) within non-OC and OC+P groups. Trabecular density of the distal tibia as measured by peripheral quantitative computed tomography decreased from baseline to 12 mo within the OC group only (P = 0.016).

Conclusions

OC use tended to promote minor negative effects on bone and consuming prunes tended to provide a potential protective effect on trabecular density of the distal tibia and ultradistal radius.

This trial was registered at www.clinicaltrials.gov as NCT04785131.

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西梅可减轻口服避孕药对年轻成年女性骨骼健康的不良影响:一项随机临床试验
背景口服避孕药(OCs)可能会促进骨质流失,从而导致日后骨质健康状况不佳。本研究的目的是确定每天摄入 50 克西梅 12 个月是否能防止年轻(18-25 岁)OC 使用者的骨质流失或增加骨量。方法将90名女性随机分配到不使用OC(非OC)的对照组、不摄入西梅的OC组(OC)和每天摄入50克西梅的OC组(OC+P),为期12个月。在基线和12个月后,通过双能X射线吸收测量法(所有部位)和外周定量计算机断层扫描(胫骨)测量骨质密度(BMD)。结果各组之间在饮食摄入、体力活动、血清抗酒石酸磷酸酶-5b或骨碱性磷酸酶浓度方面没有显著差异。OC组和OC+P组的基线血清C反应蛋白和维生素D浓度高于非OC组(P< 0.001)。非 OC 组血清甲状旁腺激素的基线值(P = 0.049)和最终值(P = 0.032)均高于 OC 组。通过双能 X 射线吸收测量法测量的所有部位的 BMD 在各组之间没有变化。非 OC 组和 OC+P 组的桡骨超桡骨 BMD 随时间推移而增加(P < 0.05)。通过外周定量计算机断层扫描测量的胫骨远端骨小梁密度仅在OC组从基线到12个月期间有所下降(P = 0.016)。结论使用有机酸往往会对骨骼产生轻微的负面影响,而食用梅子则往往会对胫骨远端和桡骨超桡骨的骨小梁密度产生潜在的保护作用。该试验已在 www.clinicaltrials.gov 登记为 NCT04785131。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Developments in Nutrition
Current Developments in Nutrition NUTRITION & DIETETICS-
CiteScore
5.30
自引率
4.20%
发文量
1327
审稿时长
8 weeks
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