Granulomatous hyperinflammatory state induced by dupilumab treatment for eosinophilic esophagitis

Kanak V. Kennedy MD , Anna Costello MD , Melissa A. Lerman MD, PhD , Jon M. Burnham MD , Aoife Corcoran MD , Joseph Piccione DO , Alexandra Grier MD, PhD , Kathleen Sullivan MD, PhD , Terri Whitehorn-Brown MD , Caitlin J. Alexander MD , Laura S. Finn MD , Benjamin J. Wilkins MD, PhD , Amanda B. Muir MD
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引用次数: 0

Abstract

We present the first case of a dupilumab-induced hyperinflammatory state in the setting of underlying eosinophilic esophagitis characterized by multisystem granulomatous inflammation. Although clinical trial data and subsequent real-world experience support dupilumab as a highly effective therapy for eosinophilic esophagitis, close monitoring for development of adverse symptoms following initiation remains paramount.

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治疗嗜酸性粒细胞食管炎的双鲁单抗诱发肉芽肿性高炎性状态。
我们介绍了首例在以多系统肉芽肿性炎症为特征的嗜酸性粒细胞食管炎基础上由杜匹单抗诱发高炎症状态的病例。尽管临床试验数据和随后的实际经验都证明杜比鲁单抗是治疗嗜酸性粒细胞食管炎的高效疗法,但密切监测用药后不良症状的发展仍然至关重要。
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来源期刊
The journal of allergy and clinical immunology. Global
The journal of allergy and clinical immunology. Global Immunology, Allergology and Rheumatology
CiteScore
0.70
自引率
0.00%
发文量
0
审稿时长
92 days
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