A near-infrared naphthalocyanine photosensitizer with superior light absorption and renal clearance for type-I photodynamic and photothermal combination therapy

IF 8.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chinese Chemical Letters Pub Date : 2025-06-01 Epub Date: 2024-07-23 DOI:10.1016/j.cclet.2024.110290

Li Li, Jiale Wen, Xiaojun Zhang, Shuwen Fu, Zixuan Chen, Kai Huang, Luyue Fang, Tinghe Zhao, Peipei Zhang, Xingshu Li

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Abstract

Currently, it is still a challenge to develop an organic photosensitizer (PS) with outstanding near-infrared absorption, low O₂ dependence, precise tumor targeting and rapid clearance through the kidney to improve the overall outcome of phototherapy. In this study, we have designed an organic PS (NcPB) with an excellent near-infrared light absorption through a refined molecular strategy. Meanwhile, NcPB was assembled into nanoparticles with different sizes (NanoNcPB-1 and NanoNcPB-0) by a supramolecular modulation strategy. As the results, the nanoparticle with an ultra-small size (NanoNcPB-1) generated a large number of superoxide anion (O₂^•−) in a low-O₂-dependent manner and release plenty of heat. Furthermore, the results of in vivo experiments demonstrated that NanoNcPB-1 actively accumulated in tumor tissues and showed a 92 % tumor inhibition after photodynamic and photothermal combination therapy. More importantly, NanoNcPB-1 could be rapidly cleared from the body of mice via the renal pathway, which alleviates potential side effects of prolonged retention of PS in the circulation.

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一种近红外萘酞菁光敏剂，具有优异的光吸收和肾清除能力，可用于 I 型光动力和光热联合疗法

目前，开发一种具有出色的近红外吸收、低氧依赖、精确靶向肿瘤和快速通过肾脏清除的有机光敏剂（PS），以提高光疗的整体效果仍然是一个挑战。在本研究中，我们通过精细的分子策略设计了具有优异近红外光吸收性能的有机PS （NcPB）。同时，通过超分子调制策略将NcPB组装成不同尺寸的纳米粒子（NanoNcPB-1和NanoNcPB-0）。结果表明，超小尺寸纳米颗粒（NanoNcPB-1）以低O2依赖的方式生成大量超氧阴离子（O2•−），并释放大量热量。此外，体内实验结果表明，NanoNcPB-1在肿瘤组织中积极积累，并在光动力和光热联合治疗后显示出92% %的肿瘤抑制作用。更重要的是，NanoNcPB-1可以通过肾脏途径迅速从小鼠体内清除，从而减轻了PS在循环中长期滞留的潜在副作用。

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来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.