Design and implementation of a cost-effective, open-source, and programmable pulsatile flow system

IF 2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC HardwareX Pub Date : 2024-07-21 DOI:10.1016/j.ohx.2024.e00561
Sanna E. Herwald , Daniel Y. Sze , Daniel B. Ennis , Alexander M. Vezeridis
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Abstract

The primary objective of this research was to design, implement, and validate a programmable open-source pulsatile flow system to cost-effectively simulate vascular flows. We employed an Arduino-compatible microcontroller combined with a motor driver to control a centrifugal direct current (DC) motor pump. The system was programmed to produce pulsatile flows with an arterial pulse waveform. Validation with Doppler ultrasound and flow measurements confirmed that our Arduino-based system successfully replicated arterial vascular flow. The materials are easily accessible, with a total bill of materials as low as $99. This open-source programmable pulsatile pump platform offers superior cost-effectiveness and adaptability relative to commercial offerings.

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设计并实现经济高效、开源和可编程的脉动流量系统
本研究的主要目的是设计、实现和验证一个可编程开源脉动流量系统,以经济有效的方式模拟血管流动。我们采用了与 Arduino 兼容的微控制器,结合电机驱动器来控制离心直流(DC)电机泵。通过编程,该系统可产生具有动脉脉冲波形的脉动血流。通过多普勒超声和流量测量验证,我们基于 Arduino 的系统成功地复制了动脉血管流量。材料很容易获得,总材料费低至 99 美元。与商业产品相比,这种开源可编程脉动泵平台具有更高的成本效益和适应性。
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来源期刊
HardwareX
HardwareX Engineering-Industrial and Manufacturing Engineering
CiteScore
4.10
自引率
18.20%
发文量
124
审稿时长
24 weeks
期刊介绍: HardwareX is an open access journal established to promote free and open source designing, building and customizing of scientific infrastructure (hardware). HardwareX aims to recognize researchers for the time and effort in developing scientific infrastructure while providing end-users with sufficient information to replicate and validate the advances presented. HardwareX is open to input from all scientific, technological and medical disciplines. Scientific infrastructure will be interpreted in the broadest sense. Including hardware modifications to existing infrastructure, sensors and tools that perform measurements and other functions outside of the traditional lab setting (such as wearables, air/water quality sensors, and low cost alternatives to existing tools), and the creation of wholly new tools for either standard or novel laboratory tasks. Authors are encouraged to submit hardware developments that address all aspects of science, not only the final measurement, for example, enhancements in sample preparation and handling, user safety, and quality control. The use of distributed digital manufacturing strategies (e.g. 3-D printing) is encouraged. All designs must be submitted under an open hardware license.
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