Ethnic differences in postprandial fatty acid trafficking and utilization between overweight and obese White European and Black African-Caribbean men.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM American journal of physiology. Endocrinology and metabolism Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI:10.1152/ajpendo.00164.2024
Reuben M Reed, Fariba Shojaee-Moradie, Gráinne Whelehan, Nicola Jackson, Oliver C Witard, Margot Umpleby, Barbara A Fielding, Martin B Whyte, Louise M Goff
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Abstract

Black African-Caribbean (BAC) populations are at greater risk of cardiometabolic disease than White Europeans (WE), despite exhibiting lower fasting triacylglycerol (TAG) concentrations. However, limited data exist regarding postprandial fatty acid metabolism in BAC populations. This study determined the ethnic differences in postprandial fatty acid metabolism between overweight and obese WE and BAC men. WE [n = 10, age 33.3 ± 1.7 yr; body mass index (BMI) = 26.8 (25.8-31.0) kg/m2] and BAC [n = 9, age 27.9 ± 1.0 yr; BMI = 27.5 (26.0-28.6) kg/m2] men consumed two consecutive (at 0 and 300 min) moderate-to-high-fat meals-the first labeled with [U-13C]palmitate. The plasma concentration and appearance of meal-derived fatty acids in very-low-density lipoprotein (VLDL)-TAG, chylomicron-TAG, and nonesterified fatty acid (NEFA) were determined over an 8-h postprandial period. Indirect calorimetry with 13CO2 enrichment determined total and meal-derived fatty acid oxidation rates, and plasma β-hydroxybutyrate (3-OHB) concentration was measured to assess ketogenesis. BAC exhibited lower postprandial TAG [area under the curve (AUC0-480) = 671 (563-802) vs. 469 (354-623) mmol/L/min, P = 0.022] and VLDL-TAG [AUC0-480 = 288 ± 30 vs. 145 ± 27 mmol/L/min, P = 0.003] concentrations than WE. The appearance of meal-derived fatty acids in VLDL-TAG was lower in BAC than in WE (AUC0-480 = 133 ± 12 vs. 78 ± 13 mmol/L/min, P = 0.007). Following the second meal, BAC showed a trend for lower chylomicron-TAG concentration [AUC300-480 = 69 (51-93) vs. 43 (28-67) mmol/L/min, P = 0.057]. There were no ethnic differences in the appearance of chylomicron-TAG, cumulative fatty acid oxidation, and the NEFA:3-OHB ratio (P > 0.05). In conclusion, BAC exhibit lower postprandial TAG concentrations compared with WE men, driven by lower VLDL-TAG concentrations and possibly lower chylomicron-TAG in the late postprandial period. These findings suggest that postprandial fatty acid trafficking may be a less important determinant of cardiometabolic risk in BAC than in WE men.NEW & NOTEWORTHY Postprandial TAG is lower in Black African-Caribbean men than in White European men, and this is likely driven by lower meal-derived VLDL-TAG in Black African-Caribbean men. This observation could suggest that fatty acid trafficking may be a less important determinant of cardiometabolic risk in Black Africans than in White European men.

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超重和肥胖的欧洲白人男子与非洲裔加勒比黑人男子之间在餐后脂肪酸贩运和利用方面的种族差异。
尽管空腹三酰甘油(TAG)浓度较低,但非洲-加勒比黑人(BAC)罹患心脏代谢疾病的风险却高于欧洲白人(WE)。然而,有关黑加勒比海人餐后脂肪酸代谢的数据却很有限。本研究确定了超重和肥胖的白种人与白种人之间餐后脂肪酸代谢的种族差异。WE(n=10)和 BAC(n=9)男性连续进食两顿中高脂肪餐,第一顿用 U-13C 棕榈酸酯标记。在 8 小时内测定血浆中极度低密度脂蛋白 (VLDL) -TAG、乳糜微粒 -TAG 和 NEFA 中源自膳食的脂肪酸的浓度和外观。利用 13CO2 富集间接量热法测定总脂肪酸和膳食衍生脂肪酸的氧化率,并测定血浆中 b-羟基丁酸(3-OHB)的浓度以评估酮体生成情况。BAC 的餐后 TAG(P=0.006)和 VLDL-TAG (P=0.002)浓度低于 WE。BAC 的 VLDL-TAG 中出现的餐源性脂肪酸低于 WE(P=0.004)。第二餐后,BAC 的乳糜微粒-TAG 浓度呈下降趋势(P=0.057)。乳糜微粒-TAG中出现的餐源性脂肪酸没有种族差异。WE和BAC的累积脂肪酸氧化和NEFA:3-OHB比率相似。总之,与 WE 男子相比,BAC 男子的餐后 TAG 浓度较低,其原因是 VLDL-TAG 浓度较低,也可能是餐后晚期乳糜微粒-TAG 浓度较低。在 BAC 中,VLDL-TAG 浓度较低的部分原因是 VLDL-TAG 中出现的餐源性脂肪酸较少。这些研究结果表明,与 WE 男子相比,BAC 男子餐后脂肪酸贩运对心脏代谢风险的决定作用可能较小。
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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
98
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.
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