Prognostic value of pretreatment temporal muscle thickness after curative surgery for oral cavity squamous cell carcinoma.

IF 2.4 3区医学 Q3 ONCOLOGY International Journal of Clinical Oncology Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI:10.1007/s10147-024-02591-3

Toshiyuki Mukai, Kenya Kobayashi, Koji Yamamura, Osamu Fukuoka, Kenji Kondo, Yuki Saito

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Abstract

Background: Sarcopenia is a poor prognostic factor in various diseases. Temporal muscle thickness (TMT) has been reported to be associated with sarcopenia. We investigated the prognostic value of TMT in patients with oral squamous cell carcinoma.

Methods: This study included 61 patients with oral squamous cell carcinoma. Two board-certified otolaryngologists measured TMT based on pre-treatment CT. The following sex-specific TMT cut-off values were used in accordance with previous reports: ≤ 6.3 mm in men, and ≤ 5.2 mm in women. We classified patients into normal TMT group and low TMT group according to the cutoff values. The correlation between the TMT measurements of the two readers was tested using the interclass correlation coefficient (ICC). Cox regression models were used to verify the association between TMT and prognostic factors.

Results: The low TMT group had a significantly lower BMI than the normal TMT group. Patients with low TMT at baseline had a significantly higher risk of death than those with normal TMT (hazard ratio 4.51; 95% confidence interval [CI] 1.49-13.61; p = 0.0076). There were no significant differences in disease-specific survival between the two groups. The correlation between the two evaluators' TMT measurements was excellent (ICC 0.988, 95% CI 0.981-0.933).

Conclusions: Sex-specific TMT was associated with overall survival in patients with oral squamous cell carcinoma. TMT is easy to assess and its measurement is consistent between evaluators.

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口腔鳞状细胞癌治愈手术后颞肌厚度的预后价值。

背景：肌肉疏松症是多种疾病的不良预后因素。据报道，颞肌厚度（TMT）与肌肉疏松症有关。我们研究了颞肌厚度在口腔鳞状细胞癌患者中的预后价值：本研究包括 61 名口腔鳞状细胞癌患者。两名获得医学会认证的耳鼻喉科医生根据治疗前的 CT 对 TMT 进行了测量。根据以往的报告，我们采用了以下性别特异性 TMT 临界值：男性≤ 6.3 mm，女性≤ 5.2 mm。我们根据临界值将患者分为正常 TMT 组和低 TMT 组。使用类间相关系数（ICC）检验了两位读者的 TMT 测量值之间的相关性。采用 Cox 回归模型验证 TMT 与预后因素之间的关联：低 TMT 组的 BMI 明显低于正常 TMT 组。基线TMT低的患者死亡风险明显高于TMT正常的患者（危险比4.51；95%置信区间[CI] 1.49-13.61；P = 0.0076）。两组患者的疾病特异性生存率无明显差异。两位评估者的TMT测量结果之间的相关性非常好（ICC 0.988，95% CI 0.981-0.933）：结论：性别特异性TMT与口腔鳞状细胞癌患者的总生存率相关。结论：性别特异性 TMT 与口腔鳞状细胞癌患者的总生存率相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Oncology 医学-肿瘤学

CiteScore

6.80

自引率

3.00%

发文量

175

审稿时长

2 months

期刊介绍： The International Journal of Clinical Oncology (IJCO) welcomes original research papers on all aspects of clinical oncology that report the results of novel and timely investigations. Reports on clinical trials are encouraged. Experimental studies will also be accepted if they have obvious relevance to clinical oncology. Membership in the Japan Society of Clinical Oncology is not a prerequisite for submission to the journal. Papers are received on the understanding that: their contents have not been published in whole or in part elsewhere; that they are subject to peer review by at least two referees and the Editors, and to editorial revision of the language and contents; and that the Editors are responsible for their acceptance, rejection, and order of publication.