Volume-Based Quantitative Measurement of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT Uptake Reflects the Disease Activity of IgG4-Related Disease.

IF 3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Molecular Imaging and Biology Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI:10.1007/s11307-024-01928-8

Liyan Wan, Chuanyin Sun, Junyu Liang, Jin Lin, Zhi Chen

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Abstract

Background: To investigate the potential utility of quantitative parameters obtained by ¹⁸F-fibroblast activation protein inhibitor positron emission tomography/computed tomography ([¹⁸F]AlF-NOTA-FAPI-04 PET/CT) in the assessment of organ involvement and disease activity in IgG4-related disease (IgG4-RD).

Methods: This study enrolled patients who underwent [¹⁸F]AlF-NOTA-FAPI-04 PET/CT scans at the Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine from August 2021 to August 2022. The PET/CT images of the included patients were re-evaluated by PET center technicians, and the maximal standardized uptake value (SUV_max), metabolic lesion volume (MLV), and total lesion FAPI (TL-FAPI) were used to evaluate the involved organs and tissues that abnormally accumulated [¹⁸F]AlF-NOTA-FAPI-04. The clinical and laboratory data of patients are also systematically collected and analyzed.

Results: Among the patients included in this study, 12 patients met the IgG4-RD classification criteria established by the American College of Rheumatology in 2019. Among them, 8 were males and 4 were females, with an average age of 59.3 ± 11.5 years. 50% of IgG4-RD patients were found with more organ involvement on PET/CT than physical examination, ultrasonography, and computed tomography. IgG4 levels (Rho = 0.594, p = 0.042) and IgG4-RI (Rho = 0.647, p = 0.023) were significantly positively correlated with TL-FAPI. After linear regression analysis, only TL-FAPI showed a predictive value of RI (R² = 0.356, B = 0.008, p = 0.041).

Conclusions: [¹⁸F]AlF-NOTA-FAPI-04 PET/CT is a useful tool for identifying asymptomatic organ involvement and assessing disease activity. The TL-FAPI as an indicator was positively correlated with IgG4-RD disease activity.

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基于容积的[18F]AlF-NOTA-FAPI-04 PET/CT 摄取定量测量反映了 IgG4 相关疾病的活动性。

背景：目的：探讨18F-成纤维细胞活化蛋白抑制剂正电子发射断层扫描/计算机断层扫描（[18F]AlF-NOTA-FAPI-04 PET/CT）获得的定量参数在评估IgG4相关疾病（IgG4-RD）器官受累和疾病活动性中的潜在作用：本研究招募了2021年8月至2022年8月在浙江大学医学院附属第一医院风湿免疫科接受[18F]AlF-NOTA-FAPI-04 PET/CT扫描的患者。PET 中心的技术人员对纳入患者的 PET/CT 图像进行了重新评估，并通过最大标准化摄取值（SUVmax）、代谢病灶体积（MLV）和总病灶 FAPI（TL-FAPI）来评估[18F]AlF-NOTA-FAPI-04 异常聚集的受累器官和组织。研究还系统收集并分析了患者的临床和实验室数据：在本研究纳入的患者中，有 12 名患者符合美国风湿病学会于 2019 年制定的 IgG4-RD 分类标准。其中，男性 8 人，女性 4 人，平均年龄（59.3±11.5）岁。50%的IgG4-RD患者在PET/CT检查中发现器官受累程度高于体格检查、超声波检查和计算机断层扫描。IgG4水平（Rho = 0.594，p = 0.042）和IgG4-RI（Rho = 0.647，p = 0.023）与TL-FAPI呈显著正相关。经过线性回归分析，只有 TL-FAPI 显示出 RI 的预测价值（R2 = 0.356，B = 0.008，P = 0.041）：结论：[18F]AlF-NOTA-FAPI-04 PET/CT 是确定无症状器官受累和评估疾病活动性的有用工具。作为一项指标，TL-FAPI与IgG4-RD的疾病活动性呈正相关。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.