Cognitive Impairment and Insomnia in Celiac Disease: A Systematic Review and Meta-Analysis.

IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Gut and Liver Pub Date : 2024-11-15 Epub Date: 2024-08-01 DOI:10.5009/gnl240063
Renato Beas, Ambar Godoy, Dalton A Norwood, Ysaith Orellana Ascencio, Diego Izquierdo-Veraza, Eleazar E Montalvan-Sanchez, Mirian Ramirez, Satya Kurada
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Abstract

Emerging evidence suggests a broader spectrum of celiac disease (CeD) system involvement, including neurological manifestations. We aimed to conduct a systematic review and meta-analysis of the available evidence from studies assessing the association of cognitive impairment and insomnia with CeD. A total of 259 participants with CeD were included in the studies investigating insomnia and 179 were included in studies investigating cognitive impairment. The overall pooled odds ratio for insomnia in patients with CeD was 1.83 (95% confidence interval, 1.38 to 2.42; I2=0.00%). The present study provides valuable insights into the available evidence from studies investigating cognitive impairment in patients with CeD and our systematic review and metaanalysis revealed a significant association between CeD and insomnia.

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乳糜泻患者的认知障碍和失眠:系统回顾与元分析》。
新的证据表明,乳糜泻(CeD)系统受累的范围更广,包括神经系统表现。我们旨在对评估认知障碍和失眠与乳糜泻相关性的研究中的现有证据进行系统回顾和荟萃分析。调查失眠的研究共纳入了 259 名 CeD 患者,调查认知障碍的研究共纳入了 179 名 CeD 患者。CeD患者失眠的总合几率比为1.83(95%置信区间为1.38至2.42;I2=0.00%)。本研究为研究 CeD 患者认知障碍的现有证据提供了宝贵的见解,我们的系统综述和荟萃分析表明 CeD 与失眠之间存在显著关联。
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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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