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Autoimmune Gastritis in Korean Patients with Gastric Tumors: Clinicopathologic Correlations and Diagnostic Histological Features. 韩国胃肿瘤患者的自身免疫性胃炎:临床病理相关性和诊断性组织学特征
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-07 DOI: 10.5009/gnl240223
Soomin Ahn, Tae-Se Kim, Ryoji Kushima, Jun Haeng Lee, Kyoung-Mee Kim

Background/aims: Autoimmune gastritis (AIG) is a corpus-dominant atrophic gastritis in which patients are positive for antiparietal cell antibody (APCA) and/or anti-intrinsic factor antibody. The risk of developing gastric cancer in patients with AIG remains unclear, and reliable frequency data of AIG in patients with gastric cancer are lacking.

Methods: We included 624 Korean patients with gastric tumors (612 gastric cancers and 12 neuroendocrine tumors) who had APCA results and were available for AIG evaluation. In patients with positive APCA results, endoscopy and histology findings were reviewed to diagnose AIG.

Results: Of the 624 patients, 37 (5.9%) tested positive for APCA, and ultimately, 11 (1.8%) met the diagnostic criteria for AIG (5 both endoscopy and histology findings, 4 endoscopy-only findings, 2 histology-only findings). The frequency of AIG in patients with gastric cancer was 1.3% (8/612), and that in patients with neuroendocrine tumors was 25.0% (3/12). Of the 11 patients with AIG, serum Helicobacter pylori antibody was positive in six patients (54.5%), all of whom had gastric cancer. Histologically, three patients showed pure AIG, four patients exhibited concurrent AIG and H. pylori gastritis, and the findings for four were indefinite for AIG. The pepsinogen (PG) I levels and PG I/II ratio were significantly lower in patients with gastric cancer with AIG than in patients with gastric cancer without AIG (p=0.042 and p=0.016, respectively).

Conclusions: The frequency of AIG in gastric cancer patients was very low compared to that in patients with neuroendocrine tumors. Rather, concurrent AIG and H. pylori gastritis was common in patients with AIG with gastric cancer.

背景/目的:自身免疫性胃炎(AIG)是一种以胃体为主的萎缩性胃炎,患者的抗顶叶细胞抗体(APCA)和/或抗内膜因子抗体呈阳性。AIG患者罹患胃癌的风险尚不明确,也缺乏AIG在胃癌患者中发生频率的可靠数据:我们纳入了 624 名韩国胃肿瘤患者(612 名胃癌患者和 12 名神经内分泌肿瘤患者),这些患者均有 APCA 结果,并可进行 AIG 评估。对 APCA 结果呈阳性的患者进行内镜检查和组织学检查,以诊断 AIG:在 624 名患者中,有 37 人(5.9%)的 APCA 检测结果呈阳性,最终有 11 人(1.8%)符合 AIG 诊断标准(5 人同时有内窥镜检查和组织学检查结果,4 人仅有内窥镜检查结果,2 人仅有组织学检查结果)。胃癌患者中的AIG发生率为1.3%(8/612),神经内分泌肿瘤患者中的AIG发生率为25.0%(3/12)。在 11 例 AIG 患者中,有 6 例(54.5%)血清幽门螺杆菌抗体呈阳性,他们都患有胃癌。在组织学上,3 名患者表现为纯 AIG,4 名患者表现为并发 AIG 和幽门螺杆菌胃炎,4 名患者的 AIG 结果不明确。有 AIG 的胃癌患者胃蛋白酶原 (PG) I 水平和 PG I/II 比值明显低于无 AIG 的胃癌患者(分别为 p=0.042 和 p=0.016):结论:与神经内分泌肿瘤患者相比,AIG在胃癌患者中的发生率非常低。结论:与神经内分泌肿瘤患者相比,AIG 在胃癌患者中的发病率非常低,相反,在患有 AIG 的胃癌患者中,同时患有 AIG 和幽门螺杆菌胃炎的情况很常见。
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引用次数: 0
Anxiety and Depression Are Associated with Poor Long-term Quality of Life in Moderate-to-Severe Ulcerative Colitis: Results of a 3-Year Longitudinal Study of the MOSAIK Cohort. 焦虑和抑郁与中重度溃疡性结肠炎患者长期生活质量低下有关:MOSAIK队列3年纵向研究结果。
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-07 DOI: 10.5009/gnl240146
Shin Ju Oh, Chang Hwan Choi, Sung-Ae Jung, Geun Am Song, Yoon Jae Kim, Ja Seol Koo, Sung Jae Shin, Geom Seog Seo, Kang-Moon Lee, Byung Ik Jang, Eun Suk Jung, Youngdoe Kim, Chang Kyun Lee

Background/aims: We previously reported that patients with moderate-to-severe ulcerative colitis (UC) often experience common mental disorders (CMDs) such as anxiety and depression, necessitating immediate psychological interventions within the first 4 weeks of diagnosis. In this 3-year follow-up study of the MOSAIK cohort in Korea, we examined the effects of CMDs at initial diagnosis on clinical outcomes and health-related quality of life (HRQoL).

Methods: We examined differences in clinical outcomes (evaluated based on clinical response, relapse, hospitalization, and medication use) and HRQoL (assessed using the Inflammatory Bowel Disease Questionnaire [IBDQ] and Short Form 12 [SF-12]) according to Hospital Anxiety and Depression Scale (HADS) scores at diagnosis.

Results: In a study involving 199 UC patients, 47.7% exhibited significant psychological distress (anxiety and/or depression) at diagnosis. Clinical follow-up showed no major differences in outcomes, including remission rates, response rates, or hospitalization rates, between patients with anxiety or depression at diagnosis and patients without anxiety or depression at diagnosis. The HRQoL at the end of follow-up was notably lower in those with baseline CMDs, particularly anxiety, across all domains of the IBDQ and SF-12. Linear mixed-effect models revealed that higher HADS scores, as well as higher Mayo scores, were independently associated with lower IBDQ scores and both summary domains of the SF-12. Additionally, regular attendance at follow-up visits during the study period was also related to improvements in HRQoL (all p<0.05).

Conclusions: While CMDs present at the time of UC diagnosis did not influence long-term clinical outcomes, they persistently impaired HRQoL. Our findings support the routine incorporation of psychological interventions into the long-term management of moderate-to-severe UC.

背景/目的:我们以前曾报道过,中重度溃疡性结肠炎(UC)患者通常会出现焦虑和抑郁等常见精神障碍(CMDs),因此需要在确诊后的最初 4 周内立即进行心理干预。在这项为期 3 年的韩国 MOSAIK 队列随访研究中,我们考察了初次诊断时的 CMD 对临床结果和健康相关生活质量(HRQoL)的影响:我们根据诊断时的医院焦虑和抑郁量表(HADS)评分,研究了临床结果(根据临床反应、复发、住院和用药情况进行评估)和 HRQoL(使用炎症性肠病问卷 [IBDQ] 和简表 12 [SF-12]进行评估)的差异:在一项涉及199名UC患者的研究中,47.7%的患者在确诊时表现出明显的心理困扰(焦虑和/或抑郁)。临床随访结果显示,诊断时患有焦虑症或抑郁症的患者与诊断时不患有焦虑症或抑郁症的患者在治疗效果(包括缓解率、反应率或住院率)方面没有重大差异。在 IBDQ 和 SF-12 的所有领域中,基线 CMD(尤其是焦虑)患者随访结束时的 HRQoL 明显较低。线性混合效应模型显示,较高的 HADS 得分和较高的 Mayo 得分与较低的 IBDQ 得分和 SF-12 的两个摘要领域都有独立关联。此外,在研究期间定期参加随访也与 HRQoL 的改善有关(所有 p 结论:虽然 UC 诊断时存在的 CMD 不会影响长期临床结果,但它们会持续损害 HRQoL。我们的研究结果支持将心理干预纳入中重度 UC 的长期管理中。
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引用次数: 0
Metal Stents for the Management of Massive Hemobilia in Patients with Hilum-Involving Cholangiocarcinoma Receiving Multi-Regimen Chemotherapy. 金属支架用于治疗接受多方案化疗的肝门部胆管癌患者的大量出血。
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-07 DOI: 10.5009/gnl240087
Seung Yeon Lee, Min Je Sung, Suk Pyo Shin, Hong Jae Chon, Beodeul Kang, Kwang Hyun Ko, Mamoru Takenaka, Chang-Il Kwon

Recent clinical outcomes of multi-regimen chemotherapy in patients with cholangiocarcinoma (CCC) have shown benefits in terms of overall survival. However, repeated endoscopic biliary drainage (EBD) and serious adverse events negatively affect prolongation of the survival period. The aim of this study was to investigate the prevalence of massive hemobilia and the outcomes of its management with fully covered self-expandable metal stents (FC-SEMSs) in patients with hilum-involving CCC receiving multi-regimen chemotherapy. The methods and effects of FC-SEMS placement were retrospectively investigated following the occurrence of massive hemobilia during EBD. A total of 356 patients with CCC received multi-regimen chemotherapy. Among them, 181 patients had hilar invasion, and seven patients (3.9%) developed massive hemobilia during repeated EBD using removable stents. In all cases, the tumor encased the right hepatic artery. In six patients (85.7%), hemostasis was immediately and completely achieved by inserting one or two FC-SEMSs proximal to the hilar invasion area. Therefore, if the tumor encases the right hepatic artery, massive hemobilia is likely to occur during multi-regimen chemotherapy. Thus, prompt placement of a FC-SEMS would be an effective treatment option for massive hemobilia in patients with hilum-involving CCC.

对胆管癌(CCC)患者进行多方案化疗的最新临床结果显示,患者的总生存期有所延长。然而,反复内镜胆道引流术(EBD)和严重不良事件对生存期的延长产生了负面影响。本研究旨在调查接受多方案化疗的肝门部受累 CCC 患者中大量血肿的发生率以及使用全覆盖自膨胀金属支架(FC-SEMS)治疗的效果。在 EBD 期间发生大出血后,我们对放置 FC-SEMS 的方法和效果进行了回顾性研究。共有356名CCC患者接受了多方案化疗。其中,181 例患者有肺门侵犯,7 例患者(3.9%)在使用可拆卸支架反复进行 EBD 期间出现大量出血。在所有病例中,肿瘤都包裹着右肝动脉。在六名患者(85.7%)中,通过在肝门侵犯区域近端插入一个或两个 FC-SEMS 即刻完全止血。因此,如果肿瘤包绕右肝动脉,在多方案化疗期间很可能会出现大量出血。因此,对于肝门受侵的 CCC 患者,及时置入 FC-SEMS 将是治疗大量出血的有效方法。
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引用次数: 0
Trends and Factors Related to Quality of Life in Patients with Inflammatory Bowel Disease. 与炎症性肠病患者生活质量相关的趋势和因素。
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-07 DOI: 10.5009/gnl240172
Sihyun Kim, Yu Kyung Jun, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon

Background/aims: Inflammatory bowel disease (IBD) affects health-related quality of life (HRQoL). The Short Inflammatory Bowel Disease Questionnaire (SIBDQ) score is strongly correlated with HRQoL in IBD patients. This study aimed to assess the factors influencing HRQoL in IBD patients.

Methods: In this prospective study, all patients with ulcerative colitis (UC) and Crohn's disease (CD) completed the SIBDQ at enrollment; some patients also completed a second SIBDQ at follow-up. Multiple linear regression analysis was used to determine associations between SIBDQ scores and clinical factors.

Results: A total of 1,020 patients participated (UC, 67%; CD, 33%). The median SIBDQ score was 52 (interquartile range, 44 to 59). In UC patients, the stool frequency (β=-2.333, p<0.001), Physician Global Assessment score (β=-3.950, p<0.001), fecal calprotectin level (β=-4.014, p<0.001), and corticosteroid use (β=-4.809, p=0.006) were negatively correlated with the SIBDQ score. In CD patients, the number of diarrhea episodes per day (β=-1.467, p=0.024) and Crohn's Disease Activity Index score (β=-0.045, p<0.001) were negatively correlated with the SIBDQ score. A total of 202 patients completed the second SIBDQ within a mean of 3.4 years. The distributions of SIBDQ score changes were as follows: decrease >10%, 28%; -10%10%, 43%. In both the initial SIBDQ and follow-up SIBDQ, scores for items pertaining to systemic symptoms (tension and fatigue) were relatively low.

Conclusions: Bowel movement-related problems significantly affect the HRQoL of both UC and CD patients. IBD patients scored lower on SIBDQ items related to general well-being. After 3 years of follow-up at the IBD clinic, 43% of patients showed a significant improvement in HRQoL.

背景/目的:炎症性肠病(IBD)会影响与健康相关的生活质量(HRQoL)。短期炎症性肠病问卷(SIBDQ)得分与 IBD 患者的 HRQoL 密切相关。本研究旨在评估影响 IBD 患者 HRQoL 的因素:在这项前瞻性研究中,所有溃疡性结肠炎(UC)和克罗恩病(CD)患者在入组时都填写了 SIBDQ;部分患者在随访时还填写了第二份 SIBDQ。采用多元线性回归分析确定 SIBDQ 分数与临床因素之间的关系:共有 1,020 名患者参与(UC,67%;CD,33%)。SIBDQ 评分的中位数为 52(四分位间范围为 44 至 59)。在 UC 患者中,大便次数(β=-2.333,p10%,28%;-10%10%,43%;-10%10%,43%;-10%10%,43%;-10%10%,43%;-10%10%,43%;-10%10%,43%;-10%10%,43%。在最初的 SIBDQ 和后续的 SIBDQ 中,与全身症状(紧张和疲劳)有关的项目得分相对较低:结论:排便相关问题严重影响了 UC 和 CD 患者的 HRQoL。IBD患者在SIBDQ中与一般幸福感相关的项目上得分较低。在 IBD 诊所随访 3 年后,43% 的患者的 HRQoL 有了明显改善。
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引用次数: 0
Combi-Elastography versus Transient Elastography for Assessing the Histological Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease. 联合弹性成像与瞬时弹性成像在评估代谢功能障碍相关性脂肪肝组织学严重程度方面的比较
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-29 DOI: 10.5009/gnl240198
Yun Kyu Lee, Dong Hyeon Lee, Sae Kyung Joo, Heejoon Jang, Young Ho So, Siwon Jang, Dong Ho Lee, Jeong Hwan Park, Mee Soo Chang, Won Kim

Background/aims: Combi-elastography is a B-mode ultrasound-based method in which two elastography modalities are utilized simultaneously to assess metabolic dysfunction-associated steatotic liver disease (MASLD). However, the performance of combi-elastography for diagnosing metabolic dysfunction-associated steatohepatitis (MASH) and determining fibrosis severity is unclear. This study compared the diagnostic performances of combi-elastography and vibration-controlled transient elastography (VCTE) for identifying hepatic steatosis, fibrosis, and high-risk MASH.

Methods: Participants who underwent combi-elastography, VCTE, and liver biopsy were selected from a prospective cohort of patients with clinically suspected MASLD. Combi-elastography-related parameters were acquired, and their performances were evaluated using area under the receiver-operating characteristic curve (AUROC) analysis.

Results: A total of 212 participants were included. The diagnostic performance for hepatic steatosis of the attenuation coefficient adjusted by covariates from combi-elastography was comparable to that of the controlled attenuation parameter measured by VCTE (AUROC, 0.85 vs 0.85; p=0.925). The performance of the combi-elastography-derived fibrosis index adjusted by covariates for diagnosing significant fibrosis was comparable to that of liver stiffness measured by VCTE (AUROC, 0.77 vs 0.80; p=0.573). The activity index from combi-elastography adjusted by covariates was equivalent to the FibroScan-aspartate aminotransferase score in diagnosing high-risk MASH among participants with MASLD (AUROC, 0.72 vs 0.74; p=0.792).

Conclusions: The performance of combi-elastography is similar to that of VCTE when evaluating histology of MASLD.

背景/目的:联合弹性成像是一种基于 B 型超声波的方法,其中同时使用两种弹性成像模式来评估代谢功能障碍相关性脂肪性肝病(MASLD)。然而,联合弹性成像在诊断代谢功能障碍相关性脂肪性肝炎(MASH)和确定纤维化严重程度方面的性能尚不明确。本研究比较了联合弹性成像和振动控制瞬态弹性成像(VCTE)在鉴别肝脂肪变性、肝纤维化和高危MASH方面的诊断性能:从临床疑似 MASLD 患者的前瞻性队列中挑选出接受联合弹性成像、VCTE 和肝活检的参与者。研究人员获取了联合弹性成像相关参数,并通过受体运行特征曲线下面积(AUROC)分析对这些参数的性能进行了评估:结果:共纳入 212 名参与者。经联合弹性成像的协变量调整后的衰减系数对肝脏脂肪变性的诊断性能与 VCTE 测量的受控衰减参数相当(AUROC,0.85 vs 0.85;p=0.925)。经协变量调整后,联合弹性成像得出的纤维化指数在诊断明显纤维化方面的性能与 VCTE 测量的肝脏硬度相当(AUROC,0.77 vs 0.80;p=0.573)。在诊断MASLD参与者中的高风险MASH时,经协变量调整后的联合弹性成像活动指数与FibroScan-天门冬氨酸氨基转移酶评分相当(AUROC,0.72 vs 0.74;p=0.792):结论:在评估MASLD组织学时,联合弹性成像的性能与VCTE相似。
{"title":"Combi-Elastography versus Transient Elastography for Assessing the Histological Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Yun Kyu Lee, Dong Hyeon Lee, Sae Kyung Joo, Heejoon Jang, Young Ho So, Siwon Jang, Dong Ho Lee, Jeong Hwan Park, Mee Soo Chang, Won Kim","doi":"10.5009/gnl240198","DOIUrl":"https://doi.org/10.5009/gnl240198","url":null,"abstract":"<p><strong>Background/aims: </strong>Combi-elastography is a B-mode ultrasound-based method in which two elastography modalities are utilized simultaneously to assess metabolic dysfunction-associated steatotic liver disease (MASLD). However, the performance of combi-elastography for diagnosing metabolic dysfunction-associated steatohepatitis (MASH) and determining fibrosis severity is unclear. This study compared the diagnostic performances of combi-elastography and vibration-controlled transient elastography (VCTE) for identifying hepatic steatosis, fibrosis, and high-risk MASH.</p><p><strong>Methods: </strong>Participants who underwent combi-elastography, VCTE, and liver biopsy were selected from a prospective cohort of patients with clinically suspected MASLD. Combi-elastography-related parameters were acquired, and their performances were evaluated using area under the receiver-operating characteristic curve (AUROC) analysis.</p><p><strong>Results: </strong>A total of 212 participants were included. The diagnostic performance for hepatic steatosis of the attenuation coefficient adjusted by covariates from combi-elastography was comparable to that of the controlled attenuation parameter measured by VCTE (AUROC, 0.85 vs 0.85; p=0.925). The performance of the combi-elastography-derived fibrosis index adjusted by covariates for diagnosing significant fibrosis was comparable to that of liver stiffness measured by VCTE (AUROC, 0.77 vs 0.80; p=0.573). The activity index from combi-elastography adjusted by covariates was equivalent to the FibroScan-aspartate aminotransferase score in diagnosing high-risk MASH among participants with MASLD (AUROC, 0.72 vs 0.74; p=0.792).</p><p><strong>Conclusions: </strong>The performance of combi-elastography is similar to that of VCTE when evaluating histology of MASLD.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer. 早期胃癌白球外观与临床病理特征的相关性
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-08 DOI: 10.5009/gnl240097
Dae Jin Jung, Gwang Ha Kim, Kyungbin Kim, Hye Kyung Jeon, Dong Chan Joo, Moon Won Lee, Bong Eun Lee

Background/aims: Magnifying endoscopy with narrow-band imaging (ME-NBI) enables the visualization of detailed microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. White globe appearance (WGA) is a small whitish lesion with a globular shape identified during ME-NBI for early gastric cancer (EGC). This study aimed to investigate the associations between WGA, clinicopathological characteristics, and other ME-NBI findings in patients with EGC.

Methods: The presence or absence of WGA in 122 patients (126 lesions) with an endoscopic diagnosis of EGC who underwent ME-NBI before endoscopic or surgical resection was prospectively collected and retrospectively analyzed. During ME-NBI, the MS and MV patterns and the presence of WGA and white opaque substances (WOS) were investigated. EGC cases were categorized as differentiated or undifferentiated type, and mucosal, submucosal, or advanced.

Results: Of 126 lesions, WGA was observed in 25 (19.8%). WGA was associated with tumor size (≤2 cm [17/63, 27.0%] vs >2 cm [8/63, 12.7%]; p=0.044), histologic type (differentiated type [22/89, 24.7%] vs undifferentiated type [3/37. 8.1%]; p=0.033), and tumor location (upper third [1/11, 9.1%] vs middle third [18/58, 31.0%] and lower third [6/57, 10.5%]; p=0.017). Although WGA was observed more frequently in lesions with an oval/tubular MS pattern, a fine-network MV pattern, and the absence of WOS, the difference was not statistically significant (MS pattern, p=0.358; MV pattern, p=0.212; WOS, p=0.121, respectively).

Conclusions: WGA was associated with small tumor size, differentiated-type histology, and middle-third tumor location, and was more frequently observed in lesions with an oval/tubular MS and fine-network MV patterns and the absence of WOS.

背景/目的:放大内镜窄带成像(ME-NBI)可观察到胃肠道内详细的微表面(MS)和微血管(MV)结构。白球外观(WGA)是在早期胃癌(EGC)的 ME-NBI 检查中发现的一种小的白色病变,呈球状。本研究旨在探讨EGC患者的WGA、临床病理特征和其他ME-NBI结果之间的关联:前瞻性收集并回顾性分析了122例经内镜诊断为EGC的患者(126个病灶)在内镜或手术切除前接受ME-NBI检查时是否存在WGA。在 ME-NBI 过程中,对 MS 和 MV 模式以及是否存在 WGA 和白色不透明物质 (WOS) 进行了调查。EGC病例被分为分化型和未分化型,以及粘膜型、粘膜下型和晚期型:结果:在126个病灶中,有25个(19.8%)观察到WGA。WGA与肿瘤大小(≤2 cm [17/63, 27.0%] vs >2 cm [8/63, 12.7%]; p=0.044)、组织学类型(分化型 [22/89, 24.7%]vs未分化型[3/37. 8.1%];P=0.033)和肿瘤位置(上三分之一[1/11,9.1%]vs中三分之一[18/58,31.0%]和下三分之一[6/57,10.5%];P=0.017)。虽然在椭圆形/管状MS型、细网MV型和无WOS的病灶中更常观察到WGA,但差异无统计学意义(分别为MS型,p=0.358;MV型,p=0.212;WOS,p=0.121):结论:WGA与肿瘤体积小、分化型组织学和肿瘤位置居中有关,且更常出现在具有椭圆形/管状MS和细网状MV形态以及无WOS的病灶中。
{"title":"Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer.","authors":"Dae Jin Jung, Gwang Ha Kim, Kyungbin Kim, Hye Kyung Jeon, Dong Chan Joo, Moon Won Lee, Bong Eun Lee","doi":"10.5009/gnl240097","DOIUrl":"https://doi.org/10.5009/gnl240097","url":null,"abstract":"<p><strong>Background/aims: </strong>Magnifying endoscopy with narrow-band imaging (ME-NBI) enables the visualization of detailed microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. White globe appearance (WGA) is a small whitish lesion with a globular shape identified during ME-NBI for early gastric cancer (EGC). This study aimed to investigate the associations between WGA, clinicopathological characteristics, and other ME-NBI findings in patients with EGC.</p><p><strong>Methods: </strong>The presence or absence of WGA in 122 patients (126 lesions) with an endoscopic diagnosis of EGC who underwent ME-NBI before endoscopic or surgical resection was prospectively collected and retrospectively analyzed. During ME-NBI, the MS and MV patterns and the presence of WGA and white opaque substances (WOS) were investigated. EGC cases were categorized as differentiated or undifferentiated type, and mucosal, submucosal, or advanced.</p><p><strong>Results: </strong>Of 126 lesions, WGA was observed in 25 (19.8%). WGA was associated with tumor size (≤2 cm [17/63, 27.0%] vs >2 cm [8/63, 12.7%]; p=0.044), histologic type (differentiated type [22/89, 24.7%] vs undifferentiated type [3/37. 8.1%]; p=0.033), and tumor location (upper third [1/11, 9.1%] vs middle third [18/58, 31.0%] and lower third [6/57, 10.5%]; p=0.017). Although WGA was observed more frequently in lesions with an oval/tubular MS pattern, a fine-network MV pattern, and the absence of WOS, the difference was not statistically significant (MS pattern, p=0.358; MV pattern, p=0.212; WOS, p=0.121, respectively).</p><p><strong>Conclusions: </strong>WGA was associated with small tumor size, differentiated-type histology, and middle-third tumor location, and was more frequently observed in lesions with an oval/tubular MS and fine-network MV patterns and the absence of WOS.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term and Long-term Clinical Outcomes of Combined Caudate Lobectomy for Intrahepatic Cholangiocarcinoma Involving the Hepatic Hilus: A Propensity Score Analysis. 联合尾状叶切除术治疗累及肝门的肝内胆管癌的短期和长期临床疗效:倾向评分分析
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-27 DOI: 10.5009/gnl240158
Di Zeng, Yaoqun Wang, Ningyuan Wen, Bei Li, Nansheng Cheng, Jiong Lu

Background/aims: Extended hepatectomy combined with caudate lobe resection has been approved for the radical resection of hilar cholangiocarcinoma. There was a lack of credible research on the clinical value of caudate lobectomy (CL) for intrahepatic cholangiocarcinoma involving the hepatic hilus when combined with hepatectomy. We aimed to compare the short-term and long-term outcomes of the combined procedure with those of only CL for curative resection of intrahepatic cholangiocarcinoma involving the hepatic hilus.

Methods: This single-center retrospective cohort study of patients with hilar cholangiocarcinoma was conducted from January 2007 to December 2021. Patients who underwent radical resection were enrolled in this study. The short-term and long-term clinical outcomes of the groups were compared before and after propensity score matching (PSM).

Results: A total of 282 patients were included. There were no statistically significant differences in perioperative clinical outcomes between the CL group and the non-CL group before and after PSM. Compared to patients in the non-CL group, patients in the CL group had significantly longer overall survival before and after PSM (p=0.007 before PSM, p=0.033 after PSM). Moreover, compared to the non-CL group, the CL group had longer disease-free survival before and after PSM (p<0.001 before PSM, p=0.019 after PSM).

Conclusions: The postoperative complications of the CL group were comparable to those of the non-CL group. CL improved the long-term survival of patients with intrahepatic cholangiocarcinoma involving the hepatic hilus when combined with hepatectomy. Therefore, hepatectomy combined with caudate lobe resection should be performed for patients with hilar cholangiocarcinoma.

背景/目的:扩大肝切除术联合尾状叶切除术已被批准用于肝门部胆管癌的根治性切除。对于涉及肝门的肝内胆管癌,尾状叶切除术(CL)结合肝切除术的临床价值缺乏可靠的研究。我们的目的是比较联合手术与单纯 CL 手术治愈性切除累及肝门的肝内胆管癌的短期和长期疗效:这项单中心回顾性队列研究的对象是肝门部胆管癌患者,研究时间为2007年1月至2021年12月。接受根治性切除术的患者被纳入本研究。比较了倾向评分匹配(PSM)前后两组患者的短期和长期临床结果:结果:共纳入 282 例患者。CL组和非CL组在倾向评分匹配前后的围手术期临床结果无统计学差异。与非 CL 组患者相比,CL 组患者在 PSM 前后的总生存期明显更长(PSM 前 p=0.007,PSM 后 p=0.033)。此外,与非 CL 组相比,CL 组患者在 PSM 前后的无病生存期更长(P=0.007,P=0.033):CL组的术后并发症与非CL组相当。CL联合肝切除术可提高肝内胆管癌(累及肝门)患者的长期生存率。因此,肝门部胆管癌患者应行肝切除术联合尾状叶切除术。
{"title":"Short-term and Long-term Clinical Outcomes of Combined Caudate Lobectomy for Intrahepatic Cholangiocarcinoma Involving the Hepatic Hilus: A Propensity Score Analysis.","authors":"Di Zeng, Yaoqun Wang, Ningyuan Wen, Bei Li, Nansheng Cheng, Jiong Lu","doi":"10.5009/gnl240158","DOIUrl":"https://doi.org/10.5009/gnl240158","url":null,"abstract":"<p><strong>Background/aims: </strong>Extended hepatectomy combined with caudate lobe resection has been approved for the radical resection of hilar cholangiocarcinoma. There was a lack of credible research on the clinical value of caudate lobectomy (CL) for intrahepatic cholangiocarcinoma involving the hepatic hilus when combined with hepatectomy. We aimed to compare the short-term and long-term outcomes of the combined procedure with those of only CL for curative resection of intrahepatic cholangiocarcinoma involving the hepatic hilus.</p><p><strong>Methods: </strong>This single-center retrospective cohort study of patients with hilar cholangiocarcinoma was conducted from January 2007 to December 2021. Patients who underwent radical resection were enrolled in this study. The short-term and long-term clinical outcomes of the groups were compared before and after propensity score matching (PSM).</p><p><strong>Results: </strong>A total of 282 patients were included. There were no statistically significant differences in perioperative clinical outcomes between the CL group and the non-CL group before and after PSM. Compared to patients in the non-CL group, patients in the CL group had significantly longer overall survival before and after PSM (p=0.007 before PSM, p=0.033 after PSM). Moreover, compared to the non-CL group, the CL group had longer disease-free survival before and after PSM (p<0.001 before PSM, p=0.019 after PSM).</p><p><strong>Conclusions: </strong>The postoperative complications of the CL group were comparable to those of the non-CL group. CL improved the long-term survival of patients with intrahepatic cholangiocarcinoma involving the hepatic hilus when combined with hepatectomy. Therefore, hepatectomy combined with caudate lobe resection should be performed for patients with hilar cholangiocarcinoma.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Intensive Endoscopic Burden with Esophageal Cancer Detection: A Nationwide Cohort Study. 强化内镜检查负担与食管癌检测的关系:全国队列研究
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-27 DOI: 10.5009/gnl240111
Yeunji Lee, Eunyoung Lee, Bumhee Park, Gil Ho Lee, Sun Gyo Lim, Sung Jae Shin, Choong-Kyun Noh, Kee Myung Lee

Background/aims: Early diagnosis of esophageal cancer (EC) remains challenging despite the increasing frequency of endoscopic screenings globally. The rapidly increasing number of endoscopic screenings performed over a certain period might influence diagnostic performance. This study evaluated the association between the number of endoscopic screenings and EC detection rates in a nationwide cohort.

Methods: This retrospective population-based study used the Korean National Cancer Screening Program database, comprising 32,774,742 males and females aged ≥40 years between 2015 and 2019. Negative binomial regression model and least-squares mean evaluation were used to assess the association between month of the year and EC detection rates.

Results: This study enrolled 28,032,590 participants who underwent upper endoscopy. The number of participants in the fourth quarter (October to December: 10,923,142 [39.0%]) was 2.1 times higher than that in the first quarter (January to March: 5,085,087 [18.1%]); this trend continued for all 5 years. Contrarily, detection rates for EC in the fourth quarter (0.08/1,000 person) were half that in the first quarter (0.15/1,000 person). The odds of detecting EC were lowest in November; in 2015 the odds were 0.57 (95% confidence interval, 0.41 to 0.79; p=0.001) times lower and in 2016, they were 0.51 (95% confidence interval, 0.37 to 0.68; p<0.001) times lower compared to January. The predicted detection rates showed a decreasing trend toward the end of the year (p>0.05 for all).

Conclusions: The workload of endoscopists increased excessively with the rising number of endoscopies toward the end of the year, which was reflected by the decreased EC detection rates during this period.

背景/目的:尽管全球内镜筛查的频率不断增加,但食管癌(EC)的早期诊断仍面临挑战。在一定时期内迅速增加的内镜筛查次数可能会影响诊断效果。本研究评估了全国性队列中内镜筛查次数与食管癌检出率之间的关系:这项基于人群的回顾性研究使用了韩国国家癌症筛查项目数据库,其中包括2015年至2019年期间年龄≥40岁的32 774 742名男性和女性。研究采用负二项回归模型和最小二乘法均值评价来评估年月与EC检出率之间的关系:该研究共纳入28032590名接受上内镜检查的参与者。第四季度(10 月至 12 月:10,923,142 人[39.0%])的参与人数是第一季度(1 月至 3 月:5,085,087 人[18.1%])的 2.1 倍;这一趋势持续了 5 年。相反,第四季度的心肌梗死检出率(0.08/1,000 人)是第一季度(0.15/1,000 人)的一半。11月检出EC的几率最低;2015年的几率是2015年的0.57倍(95%置信区间,0.41至0.79;P=0.001),2016年的几率是2016年的0.51倍(95%置信区间,0.37至0.68;P均为0.05):内镜医师的工作量随着年末内镜检查数量的增加而过度增加,这也反映在这一时期内癌检出率的下降上。
{"title":"Association of Intensive Endoscopic Burden with Esophageal Cancer Detection: A Nationwide Cohort Study.","authors":"Yeunji Lee, Eunyoung Lee, Bumhee Park, Gil Ho Lee, Sun Gyo Lim, Sung Jae Shin, Choong-Kyun Noh, Kee Myung Lee","doi":"10.5009/gnl240111","DOIUrl":"https://doi.org/10.5009/gnl240111","url":null,"abstract":"<p><strong>Background/aims: </strong>Early diagnosis of esophageal cancer (EC) remains challenging despite the increasing frequency of endoscopic screenings globally. The rapidly increasing number of endoscopic screenings performed over a certain period might influence diagnostic performance. This study evaluated the association between the number of endoscopic screenings and EC detection rates in a nationwide cohort.</p><p><strong>Methods: </strong>This retrospective population-based study used the Korean National Cancer Screening Program database, comprising 32,774,742 males and females aged ≥40 years between 2015 and 2019. Negative binomial regression model and least-squares mean evaluation were used to assess the association between month of the year and EC detection rates.</p><p><strong>Results: </strong>This study enrolled 28,032,590 participants who underwent upper endoscopy. The number of participants in the fourth quarter (October to December: 10,923,142 [39.0%]) was 2.1 times higher than that in the first quarter (January to March: 5,085,087 [18.1%]); this trend continued for all 5 years. Contrarily, detection rates for EC in the fourth quarter (0.08/1,000 person) were half that in the first quarter (0.15/1,000 person). The odds of detecting EC were lowest in November; in 2015 the odds were 0.57 (95% confidence interval, 0.41 to 0.79; p=0.001) times lower and in 2016, they were 0.51 (95% confidence interval, 0.37 to 0.68; p<0.001) times lower compared to January. The predicted detection rates showed a decreasing trend toward the end of the year (p>0.05 for all).</p><p><strong>Conclusions: </strong>The workload of endoscopists increased excessively with the rising number of endoscopies toward the end of the year, which was reflected by the decreased EC detection rates during this period.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Probiotics on Improving Intestinal Mucosal Permeability and Inflammation after Surgery. 益生菌对改善手术后肠道黏膜通透性和炎症的影响
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-27 DOI: 10.5009/gnl240170
Min-Jae Kim, Young Ju Lee, Zahid Hussain, Hyojin Park

Background/aims: We explored the mechanisms underlying the improvement of postoperative ileus (POI) following probiotic pretreatment. We assessed intestinal permeability, inflammation, tight junction (TJ) protein expression in the gut epithelium, and plasma interleukin (IL)-17 levels in a guinea pig model of POI.

Methods: Guinea pigs were divided into control, POI, and probiotic groups. The POI and probiotic groups underwent surgery, but the probiotic group received probiotics before the procedure. The ileum and proximal colon were harvested. Intestinal permeability was measured via horseradish peroxidase permeability. Inflammation was evaluated via leukocyte count in the intestinal wall muscle layer, and calprotectin expression in each intestinal wall layer was analyzed immunohistochemically. TJ proteins were analyzed using immunohistochemical staining, and plasma IL-17 levels were measured using an enzyme-linked immunosorbent assay.

Results: The POI group exhibited increased intestinal permeability and inflammation, whereas probiotic pretreatment reduced the extent of these POI-induced changes. Probiotics restored the expression of TJ proteins occludin and zonula occludens-1 in the proximal colon, which were increased in the POI group. Calprotectin expression significantly increased in the muscle layer of the POI group and was downregulated in the probiotic group; however, no distinct differences were observed between the mucosal and submucosal layers. Plasma IL-17 levels did not significantly differ among the groups.

Conclusions: Probiotic pretreatment may relieve POI by reducing intestinal permeability and inflammation and TJ protein expression in the gut epithelium. These findings suggest a potential therapeutic approach for POI management.

背景/目的:我们探讨了益生菌预处理改善术后回肠梗阻(POI)的机制。我们评估了豚鼠 POI 模型的肠道通透性、炎症、肠道上皮细胞中紧密连接(TJ)蛋白的表达以及血浆白细胞介素(IL)-17 水平:方法:将豚鼠分为对照组、POI 组和益生菌组。方法:豚鼠分为对照组和益生菌组,对照组和益生菌组均接受手术,但益生菌组在手术前服用益生菌。采集回肠和近端结肠。通过辣根过氧化物酶渗透性测量肠道渗透性。炎症通过肠壁肌层的白细胞计数进行评估,肠壁各层的钙蛋白表达通过免疫组化进行分析。使用免疫组化染色法分析 TJ 蛋白,使用酶联免疫吸附法测定血浆 IL-17 水平:结果:POI 组的肠道通透性和炎症增加,而益生菌预处理降低了 POI 引起的这些变化的程度。益生菌恢复了近端结肠中 TJ 蛋白闭塞素和 zonula occludens-1 的表达,而 POI 组中这两种蛋白的表达有所增加。POI 组肌肉层的钙蛋白表达明显增加,而益生菌组的钙蛋白表达则有所下降;不过,在粘膜层和粘膜下层之间没有观察到明显的差异。血浆 IL-17 水平在各组间无明显差异:结论:益生菌预处理可降低肠道通透性、炎症和肠道上皮细胞中 TJ 蛋白的表达,从而缓解 POI。这些研究结果表明,益生菌是治疗 POI 的一种潜在方法。
{"title":"Effect of Probiotics on Improving Intestinal Mucosal Permeability and Inflammation after Surgery.","authors":"Min-Jae Kim, Young Ju Lee, Zahid Hussain, Hyojin Park","doi":"10.5009/gnl240170","DOIUrl":"https://doi.org/10.5009/gnl240170","url":null,"abstract":"<p><strong>Background/aims: </strong>We explored the mechanisms underlying the improvement of postoperative ileus (POI) following probiotic pretreatment. We assessed intestinal permeability, inflammation, tight junction (TJ) protein expression in the gut epithelium, and plasma interleukin (IL)-17 levels in a guinea pig model of POI.</p><p><strong>Methods: </strong>Guinea pigs were divided into control, POI, and probiotic groups. The POI and probiotic groups underwent surgery, but the probiotic group received probiotics before the procedure. The ileum and proximal colon were harvested. Intestinal permeability was measured via horseradish peroxidase permeability. Inflammation was evaluated via leukocyte count in the intestinal wall muscle layer, and calprotectin expression in each intestinal wall layer was analyzed immunohistochemically. TJ proteins were analyzed using immunohistochemical staining, and plasma IL-17 levels were measured using an enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>The POI group exhibited increased intestinal permeability and inflammation, whereas probiotic pretreatment reduced the extent of these POI-induced changes. Probiotics restored the expression of TJ proteins occludin and zonula occludens-1 in the proximal colon, which were increased in the POI group. Calprotectin expression significantly increased in the muscle layer of the POI group and was downregulated in the probiotic group; however, no distinct differences were observed between the mucosal and submucosal layers. Plasma IL-17 levels did not significantly differ among the groups.</p><p><strong>Conclusions: </strong>Probiotic pretreatment may relieve POI by reducing intestinal permeability and inflammation and TJ protein expression in the gut epithelium. These findings suggest a potential therapeutic approach for POI management.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Korean Military Service on the Prevalence of Steatotic Liver Disease: A Longitudinal Study of Pre-enlistment and In-Service Health Check-Ups. 韩国兵役对脂肪肝患病率的影响:入伍前和服役期健康检查纵向研究》。
IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-15 Epub Date: 2024-07-02 DOI: 10.5009/gnl240077
Jaejun Lee, Jae Hyeop Jung, Sung Jun Choi, Beomman Ha, Hyun Yang, Pil Soo Sung, Si Hyun Bae, Jeong-A Yu

Background/aims: Young Korean men are obligated to serve in the military for 18 to 21 months. We investigated the effects of military service on steatotic liver disease (SLD) and other metabolic parameters.

Methods: Pre-enlistment health check-up performed from 2019 to 2022 and in-service health check-up performed from 2020 to 2022 were merged as paired data. SLD was defined as a hepatic steatosis index of 36 or higher. Hypertension (HTN) and hypertriglyceridemia were also included in the analysis.

Results: A total of 503,136 paired cases were included in the analysis. Comparing pre-enlistment and in-service health check-ups, the prevalence of SLD (22.2% vs 17.6%, p<0.001), HTN (7.6% vs 4.3%, p<0.001), and hypertriglyceridemia (8.1% vs 2.9%, p<0.001) decreased during military service. In terms of body mass index, the proportion of underweight (8.2% vs 1.4%, p<0.001) and severely obese (6.1% vs 4.9%, p<0.001) individuals decreased over time. Regarding factors associated with SLD development and resolution, age was positively associated with SLD development (odds ratio, 1.146; p<0.001) and a health check-up interval of <450 days was a protective factor for SLD development (odds ratio, 0.746; p<0.001). Those serving in the marines were less likely to develop SLD, whereas those serving in the navy were more likely to develop SLD. Serving in the army or the navy was negatively associated with SLD resolution, whereas serving in the air force was positively associated with SLD resolution.

Conclusions: The prevalence of SLD, HTN, and hypertriglyceridemia decreased substantially during Korean military service.

背景/目的:韩国年轻男性有义务服兵役18至21个月。我们研究了服兵役对脂肪肝(SLD)和其他代谢指标的影响:方法:将 2019 年至 2022 年进行的入伍前健康检查和 2020 年至 2022 年进行的服役期健康检查合并为配对数据。SLD 的定义是肝脏脂肪变性指数达到或超过 36。分析还包括高血压(HTN)和高甘油三酯血症:共有 503 136 例配对病例纳入分析。对比入伍前和入伍时的健康检查,SLD 的患病率(22.2% vs 17.6%,pConclusions:在韩国服兵役期间,SLD、高血压和高甘油三酯血症的患病率大幅下降。
{"title":"Impact of Korean Military Service on the Prevalence of Steatotic Liver Disease: A Longitudinal Study of Pre-enlistment and In-Service Health Check-Ups.","authors":"Jaejun Lee, Jae Hyeop Jung, Sung Jun Choi, Beomman Ha, Hyun Yang, Pil Soo Sung, Si Hyun Bae, Jeong-A Yu","doi":"10.5009/gnl240077","DOIUrl":"10.5009/gnl240077","url":null,"abstract":"<p><strong>Background/aims: </strong>Young Korean men are obligated to serve in the military for 18 to 21 months. We investigated the effects of military service on steatotic liver disease (SLD) and other metabolic parameters.</p><p><strong>Methods: </strong>Pre-enlistment health check-up performed from 2019 to 2022 and in-service health check-up performed from 2020 to 2022 were merged as paired data. SLD was defined as a hepatic steatosis index of 36 or higher. Hypertension (HTN) and hypertriglyceridemia were also included in the analysis.</p><p><strong>Results: </strong>A total of 503,136 paired cases were included in the analysis. Comparing pre-enlistment and in-service health check-ups, the prevalence of SLD (22.2% vs 17.6%, p<0.001), HTN (7.6% vs 4.3%, p<0.001), and hypertriglyceridemia (8.1% vs 2.9%, p<0.001) decreased during military service. In terms of body mass index, the proportion of underweight (8.2% vs 1.4%, p<0.001) and severely obese (6.1% vs 4.9%, p<0.001) individuals decreased over time. Regarding factors associated with SLD development and resolution, age was positively associated with SLD development (odds ratio, 1.146; p<0.001) and a health check-up interval of <450 days was a protective factor for SLD development (odds ratio, 0.746; p<0.001). Those serving in the marines were less likely to develop SLD, whereas those serving in the navy were more likely to develop SLD. Serving in the army or the navy was negatively associated with SLD resolution, whereas serving in the air force was positively associated with SLD resolution.</p><p><strong>Conclusions: </strong>The prevalence of SLD, HTN, and hypertriglyceridemia decreased substantially during Korean military service.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11391135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Gut and Liver
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