Association of host antimicrobial peptides with type II diabetes mellitus complications: a systematic review

IF 2.5 Q2 MULTIDISCIPLINARY SCIENCES Beni-Suef University Journal of Basic and Applied Sciences Pub Date : 2024-07-30 DOI:10.1186/s43088-024-00527-4

Hawraa Ibrahim Abdul Kareem, Suhad Hadi Mohammed

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Abstract

Background

This systematic review aims to review and assess the importance and relationship between host defence antimicrobial peptides with type 2 diabetes mellitus (T2DM) complications and the correlation of their expression with hyperglycaemic status.

Main body

The systematic search included three electronic databases (PMC, PubMed, and Google Scholar) that were searched from July to November 2023. After identifying and screening the research articles, eleven studies fulfilled the selection criteria and were included (six case–control and five cross-sectional studies). The Newcastle Ottawa Scale assessed the selected studies’ quality. Most studies indicated a correlation between certain types of AMPs and diabetic complications.

Conclusion

Hyperglycaemia in type 2 diabetes mellitus (T2DM) affects the expression of certain types of antimicrobial peptides (AMPs) which have a dual function (antibacterial and modulation of immune response) that may enhance inflammation which may correlate with the development of long-term complications, increased susceptibility to bacterial infection, and impaired wound healing.

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宿主抗菌肽与 II 型糖尿病并发症的关系：系统综述

本系统综述旨在回顾和评估宿主防御抗菌肽与 2 型糖尿病（T2DM）并发症之间的重要性和关系，以及它们的表达与高血糖状态之间的相关性。系统检索包括三个电子数据库（PMC、PubMed 和 Google Scholar），检索时间为 2023 年 7 月至 11 月。在对研究文章进行识别和筛选后，有 11 项研究符合筛选标准并被纳入其中（6 项病例对照研究和 5 项横断面研究）。纽卡斯尔-渥太华量表评估了所选研究的质量。大多数研究表明，某些类型的 AMP 与糖尿病并发症之间存在相关性。2 型糖尿病（T2DM）患者的高血糖会影响某些类型的抗菌肽（AMPs）的表达，这些抗菌肽具有双重功能（抗菌和调节免疫反应），可能会增强炎症反应，这可能与长期并发症的发生、细菌感染易感性的增加以及伤口愈合受损有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beni-Suef University Journal of Basic and Applied Sciences MULTIDISCIPLINARY SCIENCES-

CiteScore

2.60

自引率

0.00%

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期刊介绍： Beni-Suef University Journal of Basic and Applied Sciences (BJBAS) is a peer-reviewed, open-access journal. This journal welcomes submissions of original research, literature reviews, and editorials in its respected fields of fundamental science, applied science (with a particular focus on the fields of applied nanotechnology and biotechnology), medical sciences, pharmaceutical sciences, and engineering. The multidisciplinary aspects of the journal encourage global collaboration between researchers in multiple fields and provide cross-disciplinary dissemination of findings.