Atomic force microscopic investigations of transient early-stage bacterial adhesion and antibacterial activity of silver and ceria modified bioactive glass

IF 2.7 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Materials Research Pub Date : 2024-07-31 DOI:10.1557/s43578-024-01391-9
Shivani Gour, Abhijit Mukherjee, Kantesh Balani, Navdeep K. Dhami
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Abstract

Bioactive glass 58S (BG58S) is widely recognised for its bioactivity and antibacterial properties, making it a promising material for orthopaedic implant applications. This study investigates the effects of incorporating silver (BG58S-2.5Ag) and cerium oxide (BG58S-5C) into BG58S on early-stage bacterial adhesion and subsequent bacterial growth inhibition. Using a high-intensity ball milling approach, BG58S was modified with 5% cerium oxide (CeO2) and 2.5% silver (Ag) nanoparticles to create homogeneous BG58S-2.5Ag and BG58S-5C nanocomposites. Custom-made biomineral probes were employed to measure the bacterial adhesion within one second of contact with Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, using Atomic Force Microscopy (AFM). The results demonstrated that BG58S-2.5Ag showed significantly stronger transient adhesion to bacteria compared to BG58S, leading to a more effective long-term antibacterial response. Additionally, it was observed that the antibacterial effect of Ag commenced within one second of contact. These findings indicate a potential correlation between the rate of bond strengthening and cell wall penetration. This study highlights the potential for enhancing the effectiveness of antibacterial implant surfaces for various biomaterial applications.

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银和铈修饰生物活性玻璃瞬时早期细菌粘附和抗菌活性的原子力显微镜研究
生物活性玻璃 58S (BG58S) 因其生物活性和抗菌特性而广受认可,是一种很有前景的骨科植入材料。本研究探讨了在 BG58S 中加入银(BG58S-2.5Ag)和氧化铈(BG58S-5C)对早期细菌粘附和随后细菌生长抑制的影响。采用高强度球磨方法,用 5%的氧化铈(CeO2)和 2.5% 的银(Ag)纳米粒子对 BG58S 进行改性,以生成均匀的 BG58S-2.5Ag 和 BG58S-5C 纳米复合材料。利用原子力显微镜(AFM)测量了定制生物矿物探针与革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌接触一秒钟内的细菌粘附力。结果表明,与 BG58S 相比,BG58S-2.5Ag 对细菌的瞬时粘附力明显更强,从而产生了更有效的长期抗菌反应。此外,还观察到 Ag 的抗菌作用在接触后一秒钟内就开始了。这些研究结果表明,粘合力的增强速度与细胞壁的穿透力之间存在潜在的相关性。这项研究强调了在各种生物材料应用中提高抗菌植入物表面有效性的潜力。
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来源期刊
Journal of Materials Research
Journal of Materials Research 工程技术-材料科学:综合
CiteScore
4.50
自引率
3.70%
发文量
362
审稿时长
2.8 months
期刊介绍: Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory
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