Isoflavone Derivatives as Potential Anticancer Agents: Synthesis and Bioactivity Studies.

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL ChemMedChem Pub Date : 2024-08-02 DOI:10.1002/cmdc.202400420

Mamoalosi A Selepe

引用次数: 0

Abstract

Isoflavones are phenolic natural compounds with a C₆C₃C₆ framework. They possess a plethora of biological activities that are associated with putative benefits to human health. In particular, the cancer chemopreventive and chemotherapeutic potential of isoflavones has attracted the interest of researchers. Several isoflavone derivatives have been synthesised and probed for their anticancer activities. The isoflavone analogues are mainly synthesised by molecular hybridisation and other strategies that enable diversification through early or late-stage functionalisation of A-, B- and C-rings of the isoflavones. This has resulted in the discovery of isoflavone analogues with improved antiproliferative activities against several cancer cells and different mechanisms of action. In this review, the synthesis of isoflavone derivatives and their anticancer activity studies are discussed.

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作为潜在抗癌剂的异黄酮衍生物：合成与生物活性研究。

异黄酮是一种具有 C6C3C6 框架的酚类天然化合物。它们具有多种生物活性，可能对人类健康有益。特别是异黄酮的癌症化学预防和化学治疗潜力引起了研究人员的兴趣。已经合成了几种异黄酮衍生物，并对其抗癌活性进行了研究。异黄酮类似物主要是通过分子杂交和其他策略合成的，这些策略通过对异黄酮的 A 环、B 环和 C 环进行早期或晚期的官能化来实现多样化。因此，人们发现了异黄酮类似物，它们对多种癌细胞具有更好的抗增殖活性，并具有不同的作用机制。本综述将讨论异黄酮衍生物的合成及其抗癌活性研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.