Lifecourse growth and development determinants of mammographic density in Black women.

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-02 DOI:10.1158/1055-9965.EPI-24-0494
Zahna Bigham, Etienne X Holder, Angie Mae Rodday, Janis Breeze, Kerrie P Nelson, Julie R Palmer, Karen M Freund, Kimberly A Bertrand
{"title":"Lifecourse growth and development determinants of mammographic density in Black women.","authors":"Zahna Bigham, Etienne X Holder, Angie Mae Rodday, Janis Breeze, Kerrie P Nelson, Julie R Palmer, Karen M Freund, Kimberly A Bertrand","doi":"10.1158/1055-9965.EPI-24-0494","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>High mammographic density is one of the strongest breast cancer risk factors; however, determinants of high mammographic density are understudied in Black women. We assessed growth and development factors across the lifecourse in relation to mammographic density.</p><p><strong>Methods: </strong>Within the Black Women's Health Study (BWHS), we used Cumulus software to assess percent mammographic density from digital screening mammograms for 5,905 women ages 40-74. We fit linear regression models to quantify the association of lifecourse characteristics including birth weight, childhood somatotype, age at menarche, body mass index (BMI) at age 18, height, BMI at mammography, and adulthood waist-to-hip ratio with density overall and by age. We also performed a path analysis to assess the total and mediating effects of the growth and development factors on density.</p><p><strong>Results: </strong>BMI at age 18, height, BMI at mammography, and waist-to-hip ratio were significantly and inversely associated with density. On path analysis, total effects of childhood somatotype (standardized  = -0.05, p <0.001), BMI at age 18 (standardized  = -0.13, p <0.001), BMI at mammography (standardized  = -0.22, p <0.001), and waist-to-hip ratio (standardized  = -0.04, p <0.001) were associated with density.</p><p><strong>Conclusions: </strong>Several factors across the lifecourse - greater childhood somatotype, BMI at age 18, height, BMI at mammography, and waist-to-hip ratio - were associated with lower mammographic density in this cohort of Black women.</p><p><strong>Impact: </strong>Body size closer to the time of mammography may be more meaningful in determining mammographic density, though early life adiposity also influences mammographic density.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Epidemiology Biomarkers & Prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1158/1055-9965.EPI-24-0494","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: High mammographic density is one of the strongest breast cancer risk factors; however, determinants of high mammographic density are understudied in Black women. We assessed growth and development factors across the lifecourse in relation to mammographic density.

Methods: Within the Black Women's Health Study (BWHS), we used Cumulus software to assess percent mammographic density from digital screening mammograms for 5,905 women ages 40-74. We fit linear regression models to quantify the association of lifecourse characteristics including birth weight, childhood somatotype, age at menarche, body mass index (BMI) at age 18, height, BMI at mammography, and adulthood waist-to-hip ratio with density overall and by age. We also performed a path analysis to assess the total and mediating effects of the growth and development factors on density.

Results: BMI at age 18, height, BMI at mammography, and waist-to-hip ratio were significantly and inversely associated with density. On path analysis, total effects of childhood somatotype (standardized  = -0.05, p <0.001), BMI at age 18 (standardized  = -0.13, p <0.001), BMI at mammography (standardized  = -0.22, p <0.001), and waist-to-hip ratio (standardized  = -0.04, p <0.001) were associated with density.

Conclusions: Several factors across the lifecourse - greater childhood somatotype, BMI at age 18, height, BMI at mammography, and waist-to-hip ratio - were associated with lower mammographic density in this cohort of Black women.

Impact: Body size closer to the time of mammography may be more meaningful in determining mammographic density, though early life adiposity also influences mammographic density.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
黑人妇女乳房 X 线照相密度的生命周期生长和发育决定因素。
背景:高乳房X线照相密度是乳腺癌风险最高的因素之一;然而,对黑人女性高乳房X线照相密度的决定因素研究不足。我们评估了与乳房X线摄影密度相关的整个生命过程中的生长和发育因素:在 "黑人妇女健康研究"(BWHS)中,我们使用Cumulus软件评估了5905名40-74岁女性的数字筛查乳房X光照片中的乳房X光密度百分比。我们拟合了线性回归模型,以量化生命过程特征(包括出生体重、童年体型、初潮年龄、18 岁时的体重指数 (BMI)、身高、乳房 X 光检查时的体重指数以及成年后的腰臀比等)与总体和各年龄段密度的关联。我们还进行了路径分析,以评估生长发育因素对密度的总体影响和中介影响:结果:18 岁时的体重指数、身高、乳房 X 射线照相时的体重指数和腰臀比与密度呈显著的反向关系。在路径分析中,童年体型的总效应(标准化  = -0.05,p 结论:童年体型的总效应与密度之间存在着明显的反向关系:在这个黑人妇女队列中,几个贯穿生命过程的因素--较大的童年体型、18 岁时的体重指数、身高、乳房 X 光检查时的体重指数和腰臀比--与较低的乳房 X 光密度有关:影响:虽然早年的肥胖也会影响乳房X光密度,但乳房X光造影时的体型可能对确定乳房X光密度更有意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
期刊最新文献
Adverse birth and obstetric outcomes in the offspring of male adolescent and young adult cancer survivors: A nationwide population-based study. Incidence of serious complications following screening colonoscopy in adults aged 76 to 85 years old. Patterns of subsequent cancer incidence over time in patients with breast cancer. Polygenic risk score, healthy lifestyle score, and colorectal cancer risk: a prospective cohort study. Socioeconomic Inequalities in Participation in Colorectal Cancer Screening in Ontario, Canada: A decomposition analysis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1