The clinicopathological significance and prognostic value of PD-L1 in oral squamous cell carcinoma.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-08-02 DOI:10.1111/odi.15096

Yizhan Li, Wenhao Ren, Shaoming Li, Jingjing Zheng, Haiyan Gu, Ling Gao, Keqian Zhi

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Abstract

Objective: To investigate the relationship between the expression of PD-L1 in OSCC and the clinicopathological features and prognosis of patients.

Methods: We retrospectively analyzed the clinicopathological data and prognosis of 381 OSCC patients. Immunohistochemical staining was performed on OSCC tumor specimens, and the expression level of PD-L1 was evaluated according to the combined positive score (CPS). Kaplan-Meier analysis was used to identify the effect of PD-L1 expression and clinicopathological features on the prognosis of patients. Univariate and multivariate Cox regression analyses were conducted to determine the hazard factors affecting the prognosis of patients.

Results: PD-L1 overexpression was significantly associated with cervical lymph node metastasis (p = 0.018), worse clinical stage (p = 0.022), worse tumor differentiation (p = 0.046), and worse depth of invasion (DOI) (p = 0.003). Poorer clinical stage and degree of tumor differentiation were significantly associated with poorer OS and DSS in patients. PD-L1 expression was not associated with prognosis in patients with OSCC.

Conclusions: High PD-L1 expression was significantly associated with higher tumor malignancy in OSCC patients. Poorer clinical stage and degree of tumor differentiation were associated with poor prognosis in OSCC patients. Our results may help clinicians develop more appropriate individualized treatment strategies for their patients, thus improving their outcomes.

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口腔鳞状细胞癌中 PD-L1 的临床病理学意义和预后价值。

目的：探讨PD-L1在OSCC中的表达与临床病理特征和预后的关系：探讨PD-L1在OSCC中的表达与患者临床病理特征和预后之间的关系：我们回顾性分析了381例OSCC患者的临床病理数据和预后。对OSCC肿瘤标本进行免疫组化染色，并根据联合阳性评分（CPS）评估PD-L1的表达水平。Kaplan-Meier 分析用于确定 PD-L1 表达和临床病理特征对患者预后的影响。通过单变量和多变量考克斯回归分析确定影响患者预后的危险因素：结果：PD-L1过表达与宫颈淋巴结转移（p = 0.018）、临床分期（p = 0.022）、肿瘤分化（p = 0.046）和侵袭深度（DOI）（p = 0.003）显著相关。较差的临床分期和肿瘤分化程度与患者较差的OS和DSS显著相关。PD-L1的表达与OSCC患者的预后无关：结论：PD-L1的高表达与OSCC患者肿瘤恶性程度较高密切相关。结论：PD-L1的高表达与OSCC患者肿瘤恶性程度较高明显相关，而较差的临床分期和肿瘤分化程度与OSCC患者的不良预后相关。我们的研究结果可能有助于临床医生为患者制定更合适的个体化治疗策略，从而改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.