Real world prescription of beta-blockers in patients with asthma.

IF 2.4 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacoepidemiology and Drug Safety Pub Date : 2024-08-01 DOI:10.1002/pds.5806

Jihyun Lee, Pusoon Chun

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Abstract

Purpose: This study aimed to investigate the prescription of beta-blockers (β-blockers) for patients with asthma.

Methods: In this retrospective cross-sectional study using the National Patient Sample (NPS) of the Health Insurance Review and Assessment Service (HIRA) of South Korea, β-blockers and asthma medications were investigated using generic name codes provided by HIRA. Concomitant administration was identified when a β-blocker and an asthma medication were co-prescribed in one billing statement or when separate β-blocker and asthma prescriptions had overlapping dates of use.

Results: In the 1027 patients with asthma who were prescribed non-selective β-blockers (non-SBs), 3087 non-SB prescriptions were identified, of which 62.3% and 37.3% were for carvedilol and propranolol, respectively. Of the 906 patients with asthma prescribed selective β-blockers (SBs), 2942 SB prescriptions were identified, of which 48.5%, 28.3%, and 20.3% were for bisoprolol, atenolol, and nebivolol, respectively. Overall, 2149 non-SB and 2124 SB prescriptions with overlapping use dates with asthma medications were identified, which were prescribed to 726 and 657 patients, accounting for 70.7% and 72.5% of the patients receiving non-SBs and SBs, respectively. β2-agonists accounted for 39.9% of the concomitant asthma medications with overlapping dates of use with non-SBs. Co-prescribing of bronchodilators occurred at a rate of 38.7% and 45.1% for the 3087 non-SB prescriptions and 2942 SB prescriptions, respectively.

Conclusions: Carvedilol and propranolol accounted for half of all β-blockers prescribed to asthma patients. Prescribing β-blockers to patients with asthma requires caution to prevent exacerbation of asthma and drug interactions between β-blockers and co-prescribed asthma medications.

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哮喘患者使用β-受体阻滞剂的实际处方。

目的：本研究旨在调查哮喘患者使用β-受体阻滞剂（β-blockers）的处方情况：在这项回顾性横断面研究中，使用韩国健康保险审查和评估服务机构（HIRA）的全国患者样本（NPS），使用 HIRA 提供的通用名称代码对 β-受体阻滞剂和哮喘药物进行了调查。如果在一份账单中同时开具了 β-受体阻滞剂和哮喘药的处方，或单独的 β-受体阻滞剂和哮喘药处方的使用日期重叠，则可确定是否同时用药：在开具非选择性 β 受体阻滞剂（非 SB）处方的 1027 名哮喘患者中，发现了 3087 个非 SB 处方，其中 62.3% 和 37.3% 分别用于卡维地洛和普萘洛尔。在开具选择性 β 受体阻滞剂（SB）处方的 906 名哮喘患者中，共发现 2942 张 SB 处方，其中 48.5%、28.3% 和 20.3%分别用于比索洛尔、阿替洛尔和奈必洛尔。总体而言，与哮喘药物使用日期重叠的非 SB 处方有 2149 个，SB 处方有 2124 个，分别开给了 726 名和 657 名患者，分别占接受非 SB 和 SB 治疗患者的 70.7% 和 72.5%。在与非 SBs 使用日期重叠的哮喘并用药物中，β2-受体激动剂占 39.9%。在 3087 张非 SB 处方和 2942 张 SB 处方中，支气管扩张剂的联合处方率分别为 38.7% 和 45.1%：结论：卡维地洛和普萘洛尔占哮喘患者所有β受体阻滞剂处方的一半。为哮喘患者开具β受体阻滞剂处方需谨慎，以防止哮喘恶化以及β受体阻滞剂与哮喘联合用药之间的药物相互作用。

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来源期刊

Pharmacoepidemiology and Drug Safety 医学-药学

CiteScore

4.80

自引率

7.70%

发文量

173

审稿时长

3 months

期刊介绍： The aim of Pharmacoepidemiology and Drug Safety is to provide an international forum for the communication and evaluation of data, methods and opinion in the discipline of pharmacoepidemiology. The Journal publishes peer-reviewed reports of original research, invited reviews and a variety of guest editorials and commentaries embracing scientific, medical, statistical, legal and economic aspects of pharmacoepidemiology and post-marketing surveillance of drug safety. Appropriate material in these categories may also be considered for publication as a Brief Report. Particular areas of interest include: design, analysis, results, and interpretation of studies looking at the benefit or safety of specific pharmaceuticals, biologics, or medical devices, including studies in pharmacovigilance, postmarketing surveillance, pharmacoeconomics, patient safety, molecular pharmacoepidemiology, or any other study within the broad field of pharmacoepidemiology; comparative effectiveness research relating to pharmaceuticals, biologics, and medical devices. Comparative effectiveness research is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition, as these methods are truly used in the real world; methodologic contributions of relevance to pharmacoepidemiology, whether original contributions, reviews of existing methods, or tutorials for how to apply the methods of pharmacoepidemiology; assessments of harm versus benefit in drug therapy; patterns of drug utilization; relationships between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines; evaluations of risk management plans and programmes relating to pharmaceuticals, biologics and medical devices.