Emerging role and the signaling pathways of uncoupling protein 2 in kidney diseases.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI:10.1080/0886022X.2024.2381604

Song Mao

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Abstract

Objectives: Uncoupling protein 2 (UCP2) was involved in the pathogenesis and development of kidney diseases. Many signaling pathways and factors regulate the expression of UCP2. We aimed to investigate the precise role of UCP2 and its signaling pathways in kidney diseases.

Methods: We summarized the available evidence to yield a more detailed conclusion of the signal transduction pathways of UCP2 and its role in the development and progression of kidney diseases.

Results: UCP2 could interact with 14.3.3 family proteins, mitochondrial phospholipase iPLA2γ, NMDAR, glucokinase, PPARγ2. There existed a signaling pathway between UCP2 and NMDAR, PPARγ. UCP2 can inhibit the ROS production, inflammatory response, and apoptosis, which may protect against renal injury, particularly AKI. Meanwhile UCP2 can decrease ATP production and inhibit the secretion of insulin, which may alleviate chronic renal damages, such as diabetic nephropathy and kidney fibrosis.

Conclusions: Homeostasis of UCP2 is helpful for kidney health. UCP2 may play different roles in different kinds of renal injury.

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解偶联蛋白 2 在肾脏疾病中的新作用和信号通路。

目的解偶联蛋白 2（UCP2）参与了肾脏疾病的发病和发展。许多信号通路和因子调控 UCP2 的表达。我们旨在研究 UCP2 及其信号通路在肾脏疾病中的确切作用：方法：我们总结了现有证据，对 UCP2 的信号转导途径及其在肾脏疾病发生和发展中的作用得出了更详细的结论：结果：UCP2可与14.3.3家族蛋白、线粒体磷脂酶iPLA2γ、NMDAR、葡萄糖激酶、PPARγ2相互作用。UCP2 与 NMDAR、PPARγ 之间存在一条信号通路。UCP2 可抑制 ROS 生成、炎症反应和细胞凋亡，从而保护肾脏免受损伤，尤其是 AKI。同时，UCP2 可减少 ATP 的产生并抑制胰岛素的分泌，从而减轻慢性肾损伤，如糖尿病肾病和肾脏纤维化：结论：UCP2的平衡有助于肾脏健康。结论：UCP2 的平衡有助于肾脏健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.