The risk factors for chronic cough in children: A meta-analysis covering five continents

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Respiratory medicine Pub Date : 2024-07-31 DOI:10.1016/j.rmed.2024.107752

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Abstract

Background

This study aimed to explore the risk factors for chronic cough in children and provide a reference for prevention and healthcare measures.

Methods

PubMed, Web of Science, Cochrane, and EMBASE were searched for observational studies published up to April 2024. Outcome included risk factors associated with chronic cough in children. Two investigators independently searched and screened the literature, evaluated the qualities and extracted baseline datas. Results were analyzed using random-effects models with odds ratios and their 95 % confidence intervals to address heterogeneity. Subgroup analyses, sensitivity analyses and assessment of publication bias were performed. Stata17 and GRADEwas used for the meta-analysis.

Results

18 studies including 97,462 children were reviewed. Asthma(OR = 4.06, 95%CI: 2.37–6.96, P＜0.01), NO₂(OR = 1.19, 95%CI: 1.01–1.39, P = 0.031), Home remodeling history (OR = 1.82,95 % CI: 1.61–2.05, P＜0.01), Environment Tobacco Smoke(OR = 1.41, 95 % CI: 1.15–1.73, P = 0.001), Pet exposure (OR = 1.56, 95%CI: 1.25–1.95, P＜0.01), Mould (OR = 1.64,95%CI: 1.45–1.85, P＜0.01), Age＜1 year(OR = 3.19, 95 % CI: 1.8–5.63, P＜0.01) were reported as risk factors for chronic cough in children, these results were discussed qualitatively in the study.

Conclusion

Asthma, NO₂, Home remodeling history, Environment Tobacco Smoke(ETS), Pet exposure, Mould, and Age＜1 year are risk factors for chronic coughing in children. Due to the few studies and insufficient evidence, other potential risk factors need to be robustly confirmed by subsequent large-sample and multicenter trials.

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儿童慢性咳嗽的风险因素：涵盖五大洲的荟萃分析。

背景：本研究旨在探讨儿童慢性咳嗽的风险因素，并为预防和保健措施提供参考：本研究旨在探讨儿童慢性咳嗽的风险因素，为预防和保健措施提供参考：方法：检索PubMed、Web of Science、Cochrane和EMBASE上截至2024年4月发表的观察性研究。结果包括与儿童慢性咳嗽相关的风险因素。两名研究人员独立检索和筛选文献，评估文献质量并提取基线数据。使用随机效应模型分析结果，并使用几率比及其 95% 的置信区间来解决异质性问题。还进行了分组分析、敏感性分析和发表偏倚评估。荟萃分析使用了 Stata17 和 GRADE：对包括 97 462 名儿童在内的 18 项研究进行了审查。哮喘（OR= 4.06，95%CI：2.37-6.96，P＜0.01）、NO2（OR= 1.19，95%CI：1.01-1.39，P= 0.031）、家庭改造史（OR= 1.82，95%CI：1.61-2.05，P＜0.01）、环境烟草烟雾（OR= 1.41，95%CI：1.15-1.73，P=0.001）、宠物接触（OR= 1.56，95%CI：1.OR=1.41，95%CI：1.15-1.73，P=0.001）、宠物接触（OR=1.56，95%CI：1.25-1.95，P＜0.01）、霉菌（OR=1.64，95%CI：1.45-1.85，P＜0.01）、年龄＜1岁（OR=3.19，95%CI：1.8-5.63，P＜0.01）被报告为儿童慢性咳嗽的危险因素，研究对这些结果进行了定性讨论：结论：哮喘、二氧化氮、家庭改造史、环境烟草烟雾（ETS）、宠物接触、霉菌和年龄＜1 岁是儿童慢性咳嗽的危险因素。由于研究较少且证据不足，其他潜在的危险因素还需要通过后续的大样本和多中心试验加以证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.