Assessment of Cerebral White Matter Involvement in Amyotrophic Lateral Sclerosis Patients With Disease Progression and Cognitive Impairment by Fixel-Based Analysis and Neurite Orientation Dispersion and Density Imaging

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-08-01 DOI:10.1002/jmri.29557
Rui Xu MM, Ximing Wang MD, Sijia Zhu MM, Bin Jiang MM, Jiayi Wan MM, Jiali Ma MM, Yixing Yu MD, Liqiang Yu MD, Qi Fang MD, Chunhong Hu MD, Mo Zhu MD
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Abstract

Group Comparison of TBSS Results (Total ALS Patients vs. Controls). TBSS Showed Differences In Neurite Density Index (NDI), Orientation Dispersion Index (ODI), Isotropic Volume Fraction (ISO), and Fractional Anisotropy (FA) Metrics between the Two Groups. The Green Color Indicates the FA Skeleton with a Threshold of 0.2. Blue Color Refers to Regions of Decreased FA, NDI, and ISO in ALS Patients Indicator Differences. Red Color Refers to the Region of Increased ODI in ALS Patients. By Xu et al. (900-908)

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通过基于菲赛尔的分析和神经元方向分散与密度成像评估伴有疾病进展和认知障碍的肌萎缩侧索硬化症患者的大脑白质受累情况
TBSS 结果的组间比较(所有 ALS 患者与对照组)。TBSS 显示两组患者的神经元密度指数 (NDI)、方向弥散指数 (ODI)、各向同性体积分数 (ISO) 和各向异性分数 (FA) 指标存在差异。绿色表示阈值为 0.2 的 FA 骨架。蓝色表示 ALS 患者的 FA、NDI 和 ISO 指标差异降低的区域。红色表示 ALS 患者 ODI 增加的区域。作者:徐等人 (900-908)
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