Bioengineered cartilaginous grafts for repairing segmental mandibular defects

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2024-08-02 DOI:10.1177/20417314241267017
D S Abdullah Al Maruf, Hai Xin, Kai Cheng, Alejandro Garcia Garcia, Masoud Mohseni-Dargah, Eitan Ben-Sefer, Eva Tomaskovic-Crook, Jeremy Micah Crook, Jonathan Robert Clark
{"title":"Bioengineered cartilaginous grafts for repairing segmental mandibular defects","authors":"D S Abdullah Al Maruf, Hai Xin, Kai Cheng, Alejandro Garcia Garcia, Masoud Mohseni-Dargah, Eitan Ben-Sefer, Eva Tomaskovic-Crook, Jeremy Micah Crook, Jonathan Robert Clark","doi":"10.1177/20417314241267017","DOIUrl":null,"url":null,"abstract":"Reconstructing critical-sized craniofacial bone defects is a global healthcare challenge. Current methods, like autologous bone transplantation, face limitations. Bone tissue engineering offers an alternative to autologous bone, with traditional approaches focusing on stimulating osteogenesis via the intramembranous ossification (IMO) pathway. However, IMO falls short in addressing larger defects, particularly in clinical scenarios where there is insufficient vascularisation. This review explores redirecting bone regeneration through endochondral ossification (ECO), a process observed in long bone healing stimulated by hypoxic conditions. Despite its promise, gaps exist in applying ECO to bone tissue engineering experiments, requiring the elucidation of key aspects such as cell sources, biomaterials and priming protocols. This review discusses various scaffold biomaterials and cellular sources for chondrogenesis and hypertrophic chondrocyte priming, mirroring the ECO pathway. The review highlights challenges in current endochondral priming and proposes alternative approaches. Emphasis is on segmental mandibular defect repair, offering insights for future research and clinical application. This concise review aims to advance bone tissue engineering by addressing critical gaps in ECO strategies.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"55 1","pages":""},"PeriodicalIF":6.7000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tissue Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/20417314241267017","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
引用次数: 0

Abstract

Reconstructing critical-sized craniofacial bone defects is a global healthcare challenge. Current methods, like autologous bone transplantation, face limitations. Bone tissue engineering offers an alternative to autologous bone, with traditional approaches focusing on stimulating osteogenesis via the intramembranous ossification (IMO) pathway. However, IMO falls short in addressing larger defects, particularly in clinical scenarios where there is insufficient vascularisation. This review explores redirecting bone regeneration through endochondral ossification (ECO), a process observed in long bone healing stimulated by hypoxic conditions. Despite its promise, gaps exist in applying ECO to bone tissue engineering experiments, requiring the elucidation of key aspects such as cell sources, biomaterials and priming protocols. This review discusses various scaffold biomaterials and cellular sources for chondrogenesis and hypertrophic chondrocyte priming, mirroring the ECO pathway. The review highlights challenges in current endochondral priming and proposes alternative approaches. Emphasis is on segmental mandibular defect repair, offering insights for future research and clinical application. This concise review aims to advance bone tissue engineering by addressing critical gaps in ECO strategies.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
用于修复下颌骨节段性缺损的生物工程软骨移植物
重建临界大小的颅面骨缺损是一项全球性的医疗挑战。目前的方法,如自体骨移植,面临着局限性。骨组织工程提供了一种替代自体骨的方法,传统方法侧重于通过膜内骨化(IMO)途径刺激成骨。然而,膜内骨化途径无法解决较大的缺损问题,尤其是在血管化不足的临床情况下。本综述探讨了通过软骨内骨化(ECO)重新引导骨再生,这是缺氧条件下刺激长骨愈合时观察到的一个过程。尽管ECO前景广阔,但在将其应用于骨组织工程实验方面仍存在差距,需要阐明细胞来源、生物材料和预处理方案等关键方面。本综述讨论了用于软骨生成和肥大软骨细胞诱导的各种支架生物材料和细胞来源,反映了 ECO 途径。综述强调了目前软骨内引物所面临的挑战,并提出了替代方法。重点是下颌骨节段性缺损修复,为未来研究和临床应用提供启示。这篇简明扼要的综述旨在通过解决 ECO 策略中的关键差距来推动骨组织工程学的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
期刊最新文献
Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach. Synthetic injectable and porous hydrogels for the formation of skeletal muscle fibers: Novel perspectives for the acellular repair of substantial volumetric muscle loss. Unlocking the regenerative key: Targeting stem cell factors for bone renewal. Scaffold-mediated liver regeneration: A comprehensive exploration of current advances. Graphene derivative based hydrogels in biomedical applications.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1