Healthy Lifestyles Modify the Association of Melatonin Receptor 1B Gene and Ischemic Stroke: A Family-Based Cohort Study in Northern China

IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Pineal Research Pub Date : 2024-08-05 DOI:10.1111/jpi.13000
Huangda Guo, Hexiang Peng, Siyue Wang, Tianjiao Hou, Yixin Li, Hanyu Zhang, Jin Jiang, Bohao Ma, Mengying Wang, Yiqun Wu, Xueying Qin, Xun Tang, Dafang Chen, Jing Li, Yonghua Hu, Tao Wu
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Abstract

Limited research has reported the association between MTNR1B gene polymorphisms and ischemic stroke (IS), and there is insufficient evidence on whether adopting a healthy lifestyle can mitigate genetic risks in this context. This study aimed to investigate the associations between MTNR1B gene variants (rs10830963 and rs1387153) and IS, examining the potential effect of gene–lifestyle interactions on IS risk. Conducted in northern China, this family-based cohort study involved 5116 initially IS-free subjects. Genotype data for rs10830963 and rs1387153 in MTNR1B were collected. Eight modifiable lifestyle factors, including body mass index (BMI), smoking, alcohol consumption, dietary habits, physical activity, sedentary time, sleep duration, and chronotype, were considered in calculating healthy lifestyle scores. Multilevel Cox models were used to examine the associations between MTNR1B variants and IS. Participants carrying the rs10830963-G and rs1387153-T alleles exhibited an elevated IS risk. Each additional rs10830963-G allele and rs1387153-T allele increased the IS risk by 36% (HR = 1.36, 95% CI, 1.12–1.65) and 32% (HR = 1.32, 95% CI, 1.09–1.60), respectively. Participants were stratified into low, medium, and high healthy lifestyle score groups (1537, 2188, and 1391 participants, respectively). Genetic–lifestyle interactions were observed for rs10830963 and rs1387153 (p for interaction < 0.001). Notably, as the healthy lifestyle score increased, the effect of MTNR1B gene variants on IS risk diminished (p for trend < 0.001). This study underscores the association between the MTNR1B gene and IS, emphasizing that adherence to a healthy lifestyle can mitigate the genetic predisposition to IS.

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健康生活方式改变褪黑激素受体 1B 基因与缺血性脑卒中的关系:中国北方基于家庭的队列研究。
关于 MTNR1B 基因多态性与缺血性脑卒中(IS)之间关系的研究报道有限,而关于采用健康的生活方式能否降低这方面的遗传风险的证据不足。本研究旨在探讨 MTNR1B 基因变异(rs10830963 和 rs1387153)与 IS 之间的关系,研究基因与生活方式的相互作用对 IS 风险的潜在影响。这项基于家庭的队列研究在中国北方进行,共有 5116 名初始无 IS 的受试者参与。研究收集了 MTNR1B 中 rs10830963 和 rs1387153 的基因型数据。在计算健康生活方式评分时,考虑了八种可改变的生活方式因素,包括体重指数(BMI)、吸烟、饮酒、饮食习惯、体力活动、久坐时间、睡眠时间和时间型。多层次 Cox 模型用于研究 MTNR1B 变异与 IS 之间的关系。携带rs10830963-G和rs1387153-T等位基因的参与者表现出较高的IS风险。每增加一个rs10830963-G等位基因和rs1387153-T等位基因,IS风险就分别增加36%(HR = 1.36,95% CI,1.12-1.65)和32%(HR = 1.32,95% CI,1.09-1.60)。参与者被分为低、中、高健康生活方式得分组(分别为 1537 人、2188 人和 1391 人)。在 rs10830963 和 rs1387153 中观察到了基因与生活方式之间的相互作用(相互作用的 p
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来源期刊
Journal of Pineal Research
Journal of Pineal Research 医学-内分泌学与代谢
CiteScore
17.70
自引率
4.90%
发文量
66
审稿时长
1 months
期刊介绍: The Journal of Pineal Research welcomes original scientific research on the pineal gland and melatonin in vertebrates, as well as the biological functions of melatonin in non-vertebrates, plants, and microorganisms. Criteria for publication include scientific importance, novelty, timeliness, and clarity of presentation. The journal considers experimental data that challenge current thinking and welcomes case reports contributing to understanding the pineal gland and melatonin research. Its aim is to serve researchers in all disciplines related to the pineal gland and melatonin.
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