{"title":"Senotherapy preserves resilience in aging","authors":"Takumi Mikawa, Kazumichi Yoshida, Hiroshi Kondoh","doi":"10.1111/ggi.14949","DOIUrl":null,"url":null,"abstract":"<p>In aging societies, social and economic burdens of aging-related diseases are increasing significantly. Senotherapy, which targets aging by eliminating senescent cells (senolytics) or removing sources of chronic inflammation (senostatics), are proposed as novel strategies for aging-related diseases. Aged or frail people suffer a decline of tissue reserve capacity during aging. Resilience, which is much reduced in older people, is essential for recovery from diseases, stresses or crises. Impaired resilience is one of the reasons why aged people experience a gradual waning of their daily activity and an increase of multimorbidity. Calorie restriction results in senostatic alleviation of chronic inflammation, whereas senolytic drugs induce apoptosis of senescent cells, which exacerbate aging by excreting inflammatory factors. Thus, both senolytics and senostatics are expected to reduce sterile inflammation, originating from senescent cells. <b>Geriatr Gerontol Int 2024; 24: 845–849</b>.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"24 9","pages":"845-849"},"PeriodicalIF":2.4000,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.14949","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Geriatrics & Gerontology International","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ggi.14949","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In aging societies, social and economic burdens of aging-related diseases are increasing significantly. Senotherapy, which targets aging by eliminating senescent cells (senolytics) or removing sources of chronic inflammation (senostatics), are proposed as novel strategies for aging-related diseases. Aged or frail people suffer a decline of tissue reserve capacity during aging. Resilience, which is much reduced in older people, is essential for recovery from diseases, stresses or crises. Impaired resilience is one of the reasons why aged people experience a gradual waning of their daily activity and an increase of multimorbidity. Calorie restriction results in senostatic alleviation of chronic inflammation, whereas senolytic drugs induce apoptosis of senescent cells, which exacerbate aging by excreting inflammatory factors. Thus, both senolytics and senostatics are expected to reduce sterile inflammation, originating from senescent cells. Geriatr Gerontol Int 2024; 24: 845–849.
在老龄化社会中，与衰老相关的疾病造成的社会和经济负担日益加重。衰老疗法通过消除衰老细胞（衰老素）或消除慢性炎症源（衰老素）来治疗衰老，被认为是治疗衰老相关疾病的新策略。在衰老过程中，老年人或体弱者的组织储备能力会下降。老年人的复原力大大降低，而复原力对于从疾病、压力或危机中恢复至关重要。恢复能力下降是老年人日常活动逐渐减少、多病症增加的原因之一。限制卡路里摄入可减轻慢性炎症的衰老，而衰老溶解药物可诱导衰老细胞凋亡，衰老细胞通过排泄炎症因子加剧衰老。因此，衰老溶解剂和衰老抑制剂都有望减少源自衰老细胞的无菌性炎症。Geriatr Gerontol Int 2024; --：-----.
期刊介绍：
Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.
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