Geriatrics & Gerontology International最新文献

{"title":"Association Between Resolution of Constipation and Reduced Incidence of Fecal Incontinence: A Population-Based Longitudinal Study","authors":"Hiroaki Nakagawa,&nbsp;Hajime Yamazaki,&nbsp;Akihiro Ozaka,&nbsp;Ryohei Yamamoto,&nbsp;Sho Sasaki,&nbsp;Sugihiro Hamaguchi,&nbsp;Shunichi Fukuhara","doi":"10.1111/ggi.70390","DOIUrl":"10.1111/ggi.70390","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Few studies have evaluated the impact of constipation on future fecal incontinence, and none have examined whether constipation resolution reduces the incidence of fecal incontinence. We investigated the association between the resolution of constipation and the incidence of fecal incontinence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This longitudinal study included independent, community-dwelling older adults in Japan aged ≥ 75 years. Constipation and fecal incontinence were measured using a self-administered questionnaire at baseline and at the 1-year follow-up. The 2233 eligible participants without fecal incontinence at baseline were divided into a constipation group (<i>n</i> = 917) and a non-constipation group (<i>n</i> = 1316). The constipation group was further categorized into a resolved constipation group (<i>n</i> = 221) and a sustained constipation group (<i>n</i> = 642), based on whether or not they had constipation at follow-up. Logistic regression models were used to evaluate the odds ratio (OR) and 95% confidence intervals (95% CIs) for incident fecal incontinence while adjusting for potential confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fecal incontinence was developed in 106 participants (11.6%) in the constipation group and 89 participants (6.8%) in the non-constipation group. Constipation was associated with a higher incidence of fecal incontinence (multivariable-adjusted OR: 1.42 [95% CI: 1.02–2.00]). Furthermore, fecal incontinence occurred in nine participants (4.1%) in the resolved constipation group and in 72 participants (11.2%) in the sustained constipation group. Resolution of constipation was associated with the reduction in fecal incontinence (multivariable-adjusted OR: 0.35 [95% CI: 0.17–0.73]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Incidence of fecal incontinence was more common in participants with constipation, and the resolution of constipation was associated with the reduction in fecal incontinence. Constipation management could reduce the risk of fecal incontinence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From eSports to “Gam Saan Songs”: Prioritizing Cultural Fit in Digital Interventions for Older Adults","authors":"Jamie O. P. Chung,&nbsp;Eddie Kung,&nbsp;Benjamin K. P. Woo","doi":"10.1111/ggi.70385","DOIUrl":"10.1111/ggi.70385","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence and Influencing Factors of Frailty Among Middle-Aged and Older Adults With HIV/AIDS From a Global Perspective: A Systematic Review and Meta-Analysis","authors":"Yuelin Wang,&nbsp;Yunlan Jiang,&nbsp;Le Li,&nbsp;Hong Chen,&nbsp;Jing Wang,&nbsp;Mengjie Zhang,&nbsp;Xiaoyu Bai,&nbsp;Senlin Wu","doi":"10.1111/ggi.70341","DOIUrl":"10.1111/ggi.70341","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Currently, frailty has become a central issue in health management among middle-aged and older people living with HIV/AIDS (PLWHA) worldwide. The objective is to develop targeted strategies to improve frailty in this group, enhance their long-term quality of life, and advance the management of chronic diseases in healthcare settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive computer-based search was conducted across 11 databases to identify observational studies that reported the prevalence or influencing factors of frailty among middle-aged and older PLWHA. The search period spanned from the database's inception to August 19, 2025. The meta-analysis of the overall prevalence of frailty and associated factors was performed using Stata 17.0 and RevMan 5.4, respectively. Two independent researchers assessed the risk of bias using the Agency for Healthcare Research and Quality (AHRQ) and the Newcastle-Ottawa scale (NOS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study screened 43 studies from 2040 publications. The meta-analysis revealed an overall prevalence of frailty among middle-aged and older PLWHA of 12%. Factors significantly associated with frailty in this population included age ≥ 60 years, single, widowed, or divorced, low educational level, history of tobacco use, ≥ 1 comorbidities, diabetes, hepatitis, renal disease, osteoporosis, sleep disorders, neurocognitive impairment, cardiovascular disease, presence of depressive symptoms, and current CD4 cell count &lt; 200 cells/μL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on the evidence generated by this study, frailty management should be prioritized among PLWHA to support the transition of AIDS from a life-threatening disease to a manageable chronic condition, ultimately achieving the goal of enabling patients to live with quality and dignity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Item Discrimination of the 25-Question Geriatric Locomotive Function Scale Between Younger and Middle-Aged Adults and Older Adults: An Analysis Using the Item Response Theory","authors":"Shunsuke Yamashina,&nbsp;Kenta Hirohama,&nbsp;Junji Nishimoto,&nbsp;Ryo Tanaka","doi":"10.1111/ggi.70357","DOIUrl":"10.1111/ggi.70357","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The 25-item Geriatric Locomotive Function Scale is widely used to identify locomotive syndrome, a condition characterized by progressive decline in motor function. Although its reliability in older adults has been established, item-level properties across age groups remain unclear. This study examined item discrimination and difficulty using an item response theory approach and compared item characteristics between younger and middle-aged adults and older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Community-dwelling adults aged 18 years or older were classified as younger and middle-aged (&lt; 65 years) or older (≥ 65 years). The graded response model estimated item discrimination and difficulty. Discrimination was interpreted using Baker's classification, while values between 0.5 and 2.5 were considered empirically acceptable. Difficulty parameters ranged approximately from −3 to +3. Model fit was assessed using the root mean square error of approximation. Wald tests compared item parameters between age groups, and sensitivity analyses used age thresholds of 60, 70, and 75 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 866 participants, most items showed acceptable discrimination and difficulty. Pain- and social participation-related items were more discriminative in younger and middle-aged adults, whereas mobility- and anxiety-related items were more discriminative in older adults. Model fit was good (root mean square error of approximation = 0.04–0.05), and Wald tests confirmed significant item-level differences between groups. Sensitivity analyses supported the robustness of the 65-year cutoff.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Geriatric Locomotive Function Scale demonstrated statistically validated age-related item patterns. These findings support developing age-tailored short forms and adaptive screening tools for locomotive syndrome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.70357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Physical Frailty With Serum Growth Differentiation Factor-15 and Cognitive Decline: A Cross-Sectional Study","authors":"Kazuhiro Yoshiura,&nbsp;Yosuke Osuka,&nbsp;Kaori Kinoshita,&nbsp;Noriko Hori,&nbsp;Jiaqi Li,&nbsp;Georg von Fingerhut,&nbsp;Tohru Hosoyama,&nbsp;Daichi Shigemizu,&nbsp;Marie Takemura,&nbsp;Yasumoto Matsui,&nbsp;Shosuke Satake","doi":"10.1111/ggi.70377","DOIUrl":"10.1111/ggi.70377","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Growth differentiation factor-15 (GDF-15) is a biomarker reflecting aging and cellular stress, associated with physical frailty and cognitive decline. We cross-sectionally examined whether physical frailty is involved in the association between GDF-15 and cognitive decline. Understanding this association may help to consider frailty-related cognitive decline and potential preventive approaches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 134 participants aged 65 years or older, excluding those with severe renal dysfunction, immune-related diseases, and those with dementia or suspected dementia (Mini-Mental State Examination [MMSE] score ≤ 23). Serum GDF-15 levels were measured, and cognitive decline was assessed using the MMSE with a cutoff score of 27 or lower. Physical frailty was evaluated using the revised Japanese Cardiovascular Health Study criteria comprising five components: shrinking, exhaustion, weakness, slowness, and low activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A mediation analysis adjusted for age, sex, and education showed a significant indirect effect of GDF-15 on cognitive decline through physical frailty (β = 0.921, 95% confidence interval [CI]: 0.279–1.560). The total effect was also significant (β = 1.020, 95% CI: 0.030–2.010), whereas the direct effect was not significant (β = 0.100, 95% CI: −0.991 to 1.190).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study suggests a potential involvement of physical frailty in the relationship between serum GDF-15 levels and cognitive decline. Serum GDF-15 levels may have potential as a clinical indicator for frailty-related cognitive decline in the future. Further longitudinal studies are needed to explore this relationship and clarify the role of GDF-15.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-Specific Physical Activity and Its Association With Frailty Syndrome: Evidence From NHANES Using Phenotype and Index-Based Models","authors":"Fujue Ji,&nbsp;Jiao Liu,&nbsp;Jiaxuan Chen,&nbsp;Hyeonseung Rheem,&nbsp;Haesung Lee,&nbsp;Jong-Hee Kim","doi":"10.1111/ggi.70384","DOIUrl":"10.1111/ggi.70384","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Frailty syndrome is a common age-related condition associated with increased risks of disability, hospitalization, and mortality. Although physical activity (PA) is a modifiable lifestyle factor, limited research has explored how specific PA domains relate to frailty using validated multidimensional models. This study aimed to examine the associations between 4 PA domains—total PA, occupational PA (OPA), transport-related PA (TPA), and leisure-time PA (LTPA)—and frailty syndrome, as assessed by both the frailty phenotype (FP) and frailty index (FI) models in a nationally representative U.S. sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from 59 842 adults who participated in 6 cycles of the National Health and Nutrition Examination Survey (NHANES, 2007–2018). PA levels were self-reported and categorized by weekly duration based on guideline adherence (≥ 150 min/week) and distribution quartiles. Frailty was independently assessed using FP and FI models. Multivariable linear regression, subgroup, sensitivity analysis, and dose–response analyses were conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher levels of total PA and LTPA were consistently associated with lower frailty scores in both FP and FI models. The strongest inverse associations were observed for LTPA ≥ 300 min/week. In contrast, OPA and TPA showed limited or no associations after adjustment for confounders. Subgroup and sensitivity analyses supported these findings, with particularly pronounced effects among older adults (≥ 80 years) and women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LTPA demonstrated the strongest associations with lower frailty, highlighting its potential as a key target for preventive strategies and public health guidelines aimed at promoting healthy aging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Prescriptions: Addressing Stagnation in Benzodiazepine Reduction in Acute Care Geriatric Wards in Japan","authors":"Takahiko Nagamine","doi":"10.1111/ggi.70393","DOIUrl":"10.1111/ggi.70393","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Anesthesia Selection and Postoperative Outcomes in the Elderly","authors":"Ali İhsan Uysal","doi":"10.1111/ggi.70382","DOIUrl":"10.1111/ggi.70382","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Effects of Electronic Sports on Community-Dwelling Older Adults With Mild Cognitive Impairment: A Randomized Controlled Study”","authors":"Qian Wang,&nbsp;Yiheng Yao,&nbsp;Liang Liu","doi":"10.1111/ggi.70391","DOIUrl":"10.1111/ggi.70391","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Thromboembolism in Elderly Patients With Advanced Lung Cancer","authors":"Chieh-Kuo Lin,&nbsp;Chao-Chun Huang,&nbsp;Yi-Ching Chu","doi":"10.1111/ggi.70389","DOIUrl":"10.1111/ggi.70389","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}