Low Salivary IgA Levels Against PAc (361–386) as a Risk Factor for Root Caries in Older Adults

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-08-05 DOI:10.1002/cre2.945
Yu Ichikawa, Noboru Kaneko, Kaung Myat Thwin, Hidenobu Senpuku, Kaname Nohno, Hiroshi Ogawa
{"title":"Low Salivary IgA Levels Against PAc (361–386) as a Risk Factor for Root Caries in Older Adults","authors":"Yu Ichikawa,&nbsp;Noboru Kaneko,&nbsp;Kaung Myat Thwin,&nbsp;Hidenobu Senpuku,&nbsp;Kaname Nohno,&nbsp;Hiroshi Ogawa","doi":"10.1002/cre2.945","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study aimed to assess the intricate relationship between salivary IgA antibody levels to PAc (361–386) (PPA), mutans streptococci colonization, and root caries development in older adults.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>This study included 307 participants aged 76 years residing in Niigata city, Japan. Clinical oral examinations were performed at baseline in 2004 and 1 year later, during which the total number of untreated and treated root caries was assessed using the root decayed, filled tooth (DFT) index. The stimulated saliva samples were collected using the spitting method during the baseline survey. Salivary IgA antibody levels to amino acid residues 361–386 of <i>Streptococcus mutans</i> PAc were quantified using an enzyme-linked immunosorbent assay. Statistical analyses, including the <i>χ</i><sup>2</sup> test, Mann–Whitney <i>U</i> test, and logistic regressions, were performed to examine the association of increased root DFT with the independent variables.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among the 307 participants (53.1% men), the mean root DFT at baseline was 3.77 ± 3.66, and 36.5% of the study sample exhibited increased root DFT after 1 year with a mean increment of 0.36 ± 0.48. Participants with increase in root DFT after 1 year had significantly higher rates of low PPA levels (≤ 25th percentile) than those without increased root DFT (<i>p</i> = 0.020). Low PPA levels (≤ 25th percentile) were significantly more likely to have an increased risk of root caries development compared with PPA levels &gt; 25th percentile (adjusted OR: 1.88, 95% CI: 1.09–3.25).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Low PPA levels and root caries incidence correlated significantly, suggesting that low levels of salivary IgA antibody to PAc (361–386) may serve as a risk factor for increased root caries in older adults.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 4","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300535/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cre2.945","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives

This study aimed to assess the intricate relationship between salivary IgA antibody levels to PAc (361–386) (PPA), mutans streptococci colonization, and root caries development in older adults.

Materials and Methods

This study included 307 participants aged 76 years residing in Niigata city, Japan. Clinical oral examinations were performed at baseline in 2004 and 1 year later, during which the total number of untreated and treated root caries was assessed using the root decayed, filled tooth (DFT) index. The stimulated saliva samples were collected using the spitting method during the baseline survey. Salivary IgA antibody levels to amino acid residues 361–386 of Streptococcus mutans PAc were quantified using an enzyme-linked immunosorbent assay. Statistical analyses, including the χ2 test, Mann–Whitney U test, and logistic regressions, were performed to examine the association of increased root DFT with the independent variables.

Results

Among the 307 participants (53.1% men), the mean root DFT at baseline was 3.77 ± 3.66, and 36.5% of the study sample exhibited increased root DFT after 1 year with a mean increment of 0.36 ± 0.48. Participants with increase in root DFT after 1 year had significantly higher rates of low PPA levels (≤ 25th percentile) than those without increased root DFT (p = 0.020). Low PPA levels (≤ 25th percentile) were significantly more likely to have an increased risk of root caries development compared with PPA levels > 25th percentile (adjusted OR: 1.88, 95% CI: 1.09–3.25).

Conclusion

Low PPA levels and root caries incidence correlated significantly, suggesting that low levels of salivary IgA antibody to PAc (361–386) may serve as a risk factor for increased root caries in older adults.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
唾液中抗 PAc (361-386) 的低 IgA 水平是老年人患根龋的风险因素。
研究目的本研究旨在评估老年人唾液中的 PAc(361-386)(PPA)IgA 抗体水平、变异链球菌定植和牙根龋发展之间的复杂关系:研究对象包括居住在日本新泻市的 307 名 76 岁的老年人。分别于 2004 年和 1 年后进行了临床口腔检查,并在检查过程中使用根部龋坏、填充牙(DFT)指数评估了未治疗和已治疗根部龋坏的总数。在基线调查期间,采用吐唾液法收集了刺激唾液样本。采用酶联免疫吸附试验对唾液中针对变异链球菌 PAc 361-386 氨基酸残基的 IgA 抗体水平进行量化。统计分析包括χ2检验、Mann-Whitney U检验和逻辑回归,以研究牙根DFT增加与自变量的关系:在 307 名参与者(53.1% 为男性)中,基线时根部 DFT 的平均值为 3.77 ± 3.66,36.5% 的研究样本在 1 年后表现出根部 DFT 的增加,平均增量为 0.36 ± 0.48。1 年后牙根 DFT 增加的参与者中,PPA 水平低(≤ 第 25 百分位数)的比例明显高于牙根 DFT 未增加的参与者(p = 0.020)。与PPA水平>第25百分位数相比,PPA水平低(≤第25百分位数)的患者发生根龋的风险明显增加(调整后OR:1.88,95% CI:1.09-3.25):结论:PPA水平低与牙根龋发病率显著相关,表明唾液中PAc(361-386)IgA抗体水平低可能是导致老年人牙根龋增加的一个危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Clinical and Experimental Dental Research
Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.60%
发文量
165
审稿时长
26 weeks
期刊介绍: Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
期刊最新文献
The Influence of Patient-, Site-, and Implant-Related Factors on Marginal Bone Levels of Dental Implants in a Rural Population in China: A Retrospective Study. Understanding Occlusion and Temporomandibular Joint Function Using Deep Learning and Predictive Modeling Evaluation of Panoramic Radiography Diagnostic Accuracy in the Assessment of Interdental Alveolar Bone Loss Using CBCT Higher Prevalence of Tooth Loss in People With Abdominal Obesity but Normal Weight: Findings From the United States and Scottish Populations A Prediction Model for Lymph Node Metastasis of Oral Squamous Cell Carcinoma Based on Multiple Risk Factors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1