Low Salivary IgA Levels Against PAc (361–386) as a Risk Factor for Root Caries in Older Adults

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-08-05 DOI:10.1002/cre2.945
Yu Ichikawa, Noboru Kaneko, Kaung Myat Thwin, Hidenobu Senpuku, Kaname Nohno, Hiroshi Ogawa
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Abstract

Objectives

This study aimed to assess the intricate relationship between salivary IgA antibody levels to PAc (361–386) (PPA), mutans streptococci colonization, and root caries development in older adults.

Materials and Methods

This study included 307 participants aged 76 years residing in Niigata city, Japan. Clinical oral examinations were performed at baseline in 2004 and 1 year later, during which the total number of untreated and treated root caries was assessed using the root decayed, filled tooth (DFT) index. The stimulated saliva samples were collected using the spitting method during the baseline survey. Salivary IgA antibody levels to amino acid residues 361–386 of Streptococcus mutans PAc were quantified using an enzyme-linked immunosorbent assay. Statistical analyses, including the χ2 test, Mann–Whitney U test, and logistic regressions, were performed to examine the association of increased root DFT with the independent variables.

Results

Among the 307 participants (53.1% men), the mean root DFT at baseline was 3.77 ± 3.66, and 36.5% of the study sample exhibited increased root DFT after 1 year with a mean increment of 0.36 ± 0.48. Participants with increase in root DFT after 1 year had significantly higher rates of low PPA levels (≤ 25th percentile) than those without increased root DFT (p = 0.020). Low PPA levels (≤ 25th percentile) were significantly more likely to have an increased risk of root caries development compared with PPA levels > 25th percentile (adjusted OR: 1.88, 95% CI: 1.09–3.25).

Conclusion

Low PPA levels and root caries incidence correlated significantly, suggesting that low levels of salivary IgA antibody to PAc (361–386) may serve as a risk factor for increased root caries in older adults.

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唾液中抗 PAc (361-386) 的低 IgA 水平是老年人患根龋的风险因素。
研究目的本研究旨在评估老年人唾液中的 PAc(361-386)(PPA)IgA 抗体水平、变异链球菌定植和牙根龋发展之间的复杂关系:研究对象包括居住在日本新泻市的 307 名 76 岁的老年人。分别于 2004 年和 1 年后进行了临床口腔检查,并在检查过程中使用根部龋坏、填充牙(DFT)指数评估了未治疗和已治疗根部龋坏的总数。在基线调查期间,采用吐唾液法收集了刺激唾液样本。采用酶联免疫吸附试验对唾液中针对变异链球菌 PAc 361-386 氨基酸残基的 IgA 抗体水平进行量化。统计分析包括χ2检验、Mann-Whitney U检验和逻辑回归,以研究牙根DFT增加与自变量的关系:在 307 名参与者(53.1% 为男性)中,基线时根部 DFT 的平均值为 3.77 ± 3.66,36.5% 的研究样本在 1 年后表现出根部 DFT 的增加,平均增量为 0.36 ± 0.48。1 年后牙根 DFT 增加的参与者中,PPA 水平低(≤ 第 25 百分位数)的比例明显高于牙根 DFT 未增加的参与者(p = 0.020)。与PPA水平>第25百分位数相比,PPA水平低(≤第25百分位数)的患者发生根龋的风险明显增加(调整后OR:1.88,95% CI:1.09-3.25):结论:PPA水平低与牙根龋发病率显著相关,表明唾液中PAc(361-386)IgA抗体水平低可能是导致老年人牙根龋增加的一个危险因素。
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来源期刊
Clinical and Experimental Dental Research
Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.60%
发文量
165
审稿时长
26 weeks
期刊介绍: Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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