Effect of adalimumab treatment on inflammatory and hematological parameters in patients with Hidradenitis suppurativa.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-08-11 DOI:10.1080/15569527.2024.2387595
Kadir Kaya, Özlem Gevher
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引用次数: 0

Abstract

Objective: Hidradenitis suppurativa (HS), a chronic inflammatory disease that typically manifests after puberty, is characterised by painful nodules, abscesses, draining sinus tracts, and scars in areas rich in apocrine glands such as the axillary and inguinal regions. In recent years, blood-based biomarkers such as the Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR), Monocyte/Lymphocyte Ratio (MLR), Mean Platelet Volume (MPV), Systemic Immune-Inflammation Index (SII) and Pan-Immune-Inflammation Value (PIV) have been used as significant indicators of systemic inflammation. While there are few studies evaluating these biomarkers in HS, the response of these markers to treatment has only been assessed in one study to date. Our study aims to investigate the effect of adalimumab treatment on blood-based systemic inflammation biomarkers in HS, where inflammation plays a significant role.

Methods: The study included 42 adult patients who received adalimumab treatment at our dermatology and venereology clinic between January 2020 and January 2023. Medical records for complete blood count results of the patients were retrospectively reviewed. All systemic inflammation-based biomarkers were calculated from the absolute values of the complete blood count. The SII was calculated with the following formula: (neutrophil count × platelet count/lymphocyte count). The PIV was calculated as follows: (neutrophil count × platelet count × monocyte count/lymphocyte count). Values before the treatment and at the 12th week of treatment were compared.

Results: When the changes in the inflammatory parameters of the patients were examined, it was found that NLR (2.13 ± 0.87 vs 2.26 ± 1.12), PLR (111.01 ± 39.89 vs 99.43 ± 35.34), MLR (0.27 ± 0.11 vs 0.28 ± 0.12), MPV (9.59 ± 0.71 vs 9.70 ± 0.79), SII (680.79 ± 330.18 vs 687.89 ± 442.66), and PIV (552.02 ± 330.71 vs 605.05 ± 415.96) values did not change statistically significantly after treatment (p > 0.05). While there was a significant decrease in platelet count compared to before treatment, no statistically significant difference was found in the other evaluated blood cells.

Conclusion: Adalimumab treatment has not had a significant effect on systemic inflammation markers in HS, an inflammatory disease. More studies are needed to evaluate the effect of adalimumab on these markers in HS.

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阿达木单抗治疗对化脓性扁平湿疹患者炎症和血液指标的影响
目的:化脓性扁平湿疹(HS)是一种慢性炎症性疾病,通常在青春期后发病,其特征是在腋窝和腹股沟等分泌腺丰富的部位出现疼痛性结节、脓肿、引流窦道和疤痕。近年来,中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、单核细胞/淋巴细胞比值(MLR)、平均血小板体积(MPV)、全身免疫炎症指数(SII)和泛免疫炎症值(PIV)等基于血液的生物标志物已被用作全身炎症的重要指标。虽然评估 HS 中这些生物标志物的研究不多,但迄今为止只有一项研究评估了这些标志物对治疗的反应。我们的研究旨在探讨阿达木单抗治疗对HS血液系统炎症生物标志物的影响,因为炎症在HS中起着重要作用:研究纳入了2020年1月至2023年1月期间在我院皮肤病与性病诊所接受阿达木单抗治疗的42名成年患者。对患者的全血细胞计数结果的医疗记录进行了回顾性审查。所有以全身炎症为基础的生物标志物都是根据全血细胞计数的绝对值计算得出的。SII 用以下公式计算:(中性粒细胞计数 x 血小板计数/淋巴细胞计数)。PIV 的计算公式如下(中性粒细胞计数 x 血小板计数 x 单核细胞计数/淋巴细胞计数)。比较治疗前和治疗第 12 周时的数值:检查患者炎症参数的变化时发现,NLR(2,13 ± 0,87 vs 2,26 ± 1,12)、PLR(111,01 ± 39,89 vs 99,43 ± 35,34)、MLR(0,27 ± 0,11 vs 0,28 ± 0、12)、MPV(9,59 ± 0,71 vs 9,70 ± 0,79)、SII(680,79 ± 330,18 vs 687,89 ± 442,66)和 PIV(552,02 ± 330,71 vs 605,05 ± 415,96)值在治疗后没有显著的统计学变化(P > 0.05).与治疗前相比,血小板数量明显减少,但其他被评估的血细胞在统计学上没有明显差异:结论:阿达木单抗治疗对HS这种炎症性疾病的全身炎症指标没有明显影响。结论:阿达木单抗治疗对HS这种炎症性疾病的全身炎症指标没有明显影响,还需要更多研究来评估阿达木单抗对HS这些指标的影响。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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