Retrospective analysis on the occurrence of kidney cysts in mice in a central animal facility in the years 2009-2019.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Laboratory Animals Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI:10.1177/00236772241242538
Katrin Becker
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Abstract

Kidney cysts in humans are mainly caused by inheritable polycystic kidney disease. Although they are a regular finding in laboratory mice, their occurrence upon dissection has not been systematically investigated, yet. Therefore, the aim of this report was to investigate on prevalence, phenotype and aetiology of spontaneously occurring kidney cysts in mice by retrospectively analysing the laboratory-receipt tables of the in-house laboratory of a central animal facility in North Rhine-Westphalia, Germany, years 2009-2019. A percentage of 0.4% of dissected mice displayed kidney cysts, with more male than female animals affected and average age equal to that of all dissected animals. Preliminary report in half of the cases was distended abdomen, and a few individuals displayed additional pathologic alterations of kidneys, most commonly dilated renal pelvis, or extrarenal comorbidities. Kidney cysts occurred independently of a renal phenotype of the transgenic strain or presence of infectious agents in health monitoring. To conclude, kidney cysts were characterized as harmless for affected mice but, as inheritability is suggested according with the literature, affected animals should be excluded from breeding.

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2009-2019 年中央动物设施小鼠肾囊肿发生率的回顾性分析。
人类肾囊肿主要由遗传性多囊肾引起。虽然肾囊肿是实验室小鼠的常见病,但尚未对其解剖后的发生情况进行系统研究。因此,本报告旨在通过回顾性分析德国北莱茵-威斯特法伦州一家中央动物设施内部实验室 2009-2019 年的实验室收据表,研究小鼠自发肾囊肿的发病率、表型和病因。0.4%的解剖小鼠显示出肾囊肿,受影响的雄性动物多于雌性动物,平均年龄与所有解剖动物相同。半数病例的初步报告为腹胀,少数病例的肾脏出现其他病理改变,最常见的是肾盂扩张或肾外合并症。肾囊肿的发生与转基因菌株的肾脏表型或健康监测中是否存在感染性病原体无关。总之,肾囊肿对受影响的小鼠无害,但根据文献,肾囊肿具有遗传性,因此受影响的动物应排除在育种之外。
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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
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