Therapeutic prospects of microRNAs derived from mesenchymal stem cell extracellular vesicles in rheumatoid arthritis: a comprehensive overview.

IF 3.5 2区生物学 Q3 CELL BIOLOGY Molecular and Cellular Biochemistry Pub Date : 2025-03-01 Epub Date: 2024-08-06 DOI:10.1007/s11010-024-05082-1

Armin Akbarzadeh, Mohammad Hadi Gerami, Majid Reza Farrokhi, Shima Shapoori, Morteza Jafarinia

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammatory joint damage. Recent studies have focused on the significance of microRNAs (miRNAs) in the pathogenesis of RA. Mesenchymal stem cells (MSCs) have emerged as a potential therapeutic option for RA based on their regenerative and immunomodulatory properties. MSCs release extracellular vesicles (EVs) containing miRNAs that can modulate immune and inflammatory responses. This article provides a comprehensive overview of the current evidence on the existence of various MSCs-derived miRNAs involved in the pathophysiology, characterization, and treatment of RA. An overview of the miRNA profiles in MSC-EVs is provided, along with an examination of their impact on various cell types implicated in RA pathogenesis, including synovial fibroblasts, macrophages, and T cells. Furthermore, the therapeutic capability of MSC-EVs for miRNA-based therapies in RA is discussed. In total, this review can present an extensive view of the complex interaction between EVs and MSC-derived miRNAs in RA and thus suggest valuable strategies for developing new therapeutic approaches to target this debilitating disease.

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间充质干细胞细胞外囊泡衍生的微RNA在类风湿性关节炎中的治疗前景：综述。

类风湿性关节炎（RA）是一种慢性自身免疫性疾病，以关节炎性损伤为特征。最近的研究重点是微RNA（miRNA）在类风湿性关节炎发病机制中的重要作用。间充质干细胞（MSCs）具有再生和免疫调节的特性，因此已成为治疗风湿性关节炎的潜在疗法。间充质干细胞释放的细胞外囊泡（EVs）含有可调节免疫和炎症反应的miRNAs。本文全面综述了目前关于间充质干细胞衍生的各种miRNA参与RA的病理生理学、表征和治疗的证据。文章概述了间充质干细胞-EVs 中的 miRNA 图谱，并研究了它们对与 RA 发病机制有关的各种细胞类型（包括滑膜成纤维细胞、巨噬细胞和 T 细胞）的影响。此外，还讨论了间充质干细胞-EV 对基于 miRNA 的 RA 治疗方法的治疗能力。总之，这篇综述可以广泛地展示EVs和间充质干细胞衍生的miRNAs在RA中的复杂相互作用，从而为开发针对这种使人衰弱的疾病的新疗法提出有价值的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.