Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-11-15 DOI:10.1093/ajh/hpae102

Xinchun Xu, Qiong Li, Qiuping Chen, Haibo Wang, Chuchu Wu, Xiaohu Chen, Fei Chen, Chaoyan Yue

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Abstract

Background: We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk by employing a 2-sample Mendelian randomization (TSMR) framework.

Methods: Utilizing large-scale genome-wide association studies-retrieved data, we employed various Mendelian randomization (MR) techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP's causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran's Q statistic.

Results: The findings highlighted a significant association between elevated systolic BP (SBP; IVW: OR = 3.09, 95% CI: 1.11-8.61, P = 0.031) and increased diastolic BP (DBP; IVW: OR = 2.17, 95% CI: 1.14-6.21, P = 0.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results.

Conclusions: The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, which provides genetic evidence for a reduced risk of CAD under BP control.

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血压升高：由基因决定的脑动脉夹层风险因素。

背景：我们旨在采用双样本孟德尔随机化（TSMR）框架研究血压（BP）水平与脑动脉夹层（CAD）风险之间的潜在因果关系：利用大规模全基因组关联研究（GWAS）检索到的数据，我们采用了各种 MR 技术，包括反方差加权（IVW）、MR-Egger 回归、加权中位数和加权模式，以确定血压对 CAD 的因果影响。计算MR-Egger截距以评估是否存在多向性，并通过Cochran's Q统计量确定异质性：研究结果表明，收缩压升高（SBP；IVW：OR=3.09，95% CI：1.11-8.61，p=0.031）和舒张压升高（DBP；IVW：OR=2.17，95% CI：1.14-6.21，p=0.023）与 CAD 风险之间存在明显关联。敏感性分析加强了这些结果的稳健性和可靠性：这项 TSMR 研究的结果表明，高 SBP 和 DBP 与患 CAD 的可能性增加之间存在因果关系，这为控制血压可降低患 CAD 的风险提供了遗传学证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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