Clinical features, surgical management and outcome of squamous and basal cell carcinoma in squamates and chelonians.

IF 1.9 3区 农林科学 Q3 DERMATOLOGY Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-07 DOI:10.1111/vde.13282
Ferran Solanes-Vilanova, Koen Chiers, Javier Gil-Lianes, Tom Hellebuyck
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Abstract

Background: Squamous cell carcinoma (SCC) is one of the most commonly diagnosed neoplastic disorders in reptiles. Recently, however, it has been demonstrated that basal cell carcinomas (BCCs) are frequently misclassified as SCCs. Several histological SCC and BCC variants have been characterised and their classification may allow the establishment of appropriate prognosis estimation and treatment approaches.

Hypothesis/objectives: To describe the clinical features and surgical outcomes of SCCs and BCCs diagnosed between 2010 and 2022 in reptiles.

Animals: Thirty-three captive reptiles (21 squamates and 12 chelonians).

Materials and methods: Detailed clinical history, including staging and surgical outcomes, were performed. Statistical analysis assessed significant factors using Prism (v8.2.1).

Results: While SCC was predominantly diagnosed in lizards, BCC was most commonly diagnosed in chelonians, and both neoplasms mainly occurred in adult to aged, male individuals. Although the gross pathological findings were highly comparable between SCC and BCC, considerable variation could be seen according to the primary location (oral, cutaneous or epidermis of the shell). Humane euthanasia or noncurative intent surgeries were performed in a minority of the cases. Curative intent surgeries were successful in 19 of 27 cases during a 1- to 7-year follow-up period, yet recurrence was seen in 8 cases. The results of this study allowed the identification of significant high-risk prognostic factors for SCC and BCC in reptiles.

Conclusions and clinical relevance: This study contributes to predicting the clinical behaviour and prognosis of distinct SCC and BCC histological variants, and selecting the most appropriate treatment protocol.

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有鳞类和螯足类鳞状细胞癌和基底细胞癌的临床特征、手术治疗和结果。
背景:鳞状细胞癌(SCC)是爬行动物最常诊断出的肿瘤性疾病之一。然而,最近的研究表明,基底细胞癌(BCC)经常被误诊为鳞状细胞癌。对几种组织学上的 SCC 和 BCC 变体进行了特征描述,对它们进行分类有助于建立适当的预后评估和治疗方法:描述 2010 年至 2022 年期间在爬行动物中诊断出的 SCC 和 BCC 的临床特征和手术结果:33只人工饲养的爬行动物(21只有鳞类和12只螯足类):详细的临床病史,包括分期和手术结果。统计分析使用 Prism(v8.2.1)对重要因素进行评估:结果:SCC主要确诊于蜥蜴,而BCC则最常确诊于螯虾,两种肿瘤都主要发生在成年到老年的雄性个体身上。虽然 SCC 和 BCC 的大体病理结果非常相似,但根据原发部位(口腔、皮肤或外壳表皮)的不同,两者的病理结果也有很大差异。少数病例实施了人道安乐死或非治愈性手术。在 1 至 7 年的随访期间,27 例病例中有 19 例成功实施了治愈性手术,但仍有 8 例复发。这项研究的结果有助于确定爬行动物 SCC 和 BCC 的重要高危预后因素:本研究有助于预测不同的 SCC 和 BCC 组织学变异的临床表现和预后,并选择最合适的治疗方案。
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来源期刊
Veterinary dermatology
Veterinary dermatology 农林科学-兽医学
CiteScore
3.20
自引率
21.40%
发文量
92
审稿时长
12-24 weeks
期刊介绍: Veterinary Dermatology is a bi-monthly, peer-reviewed, international journal which publishes papers on all aspects of the skin of mammals, birds, reptiles, amphibians and fish. Scientific research papers, clinical case reports and reviews covering the following aspects of dermatology will be considered for publication: -Skin structure (anatomy, histology, ultrastructure) -Skin function (physiology, biochemistry, pharmacology, immunology, genetics) -Skin microbiology and parasitology -Dermatopathology -Pathogenesis, diagnosis and treatment of skin diseases -New disease entities
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