Proprioceptors of the human pericardium.

IF 7.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Basic Research in Cardiology Pub Date : 2024-08-09 DOI:10.1007/s00395-024-01075-9
Lea M Piermaier, Svenja Caspers, Christina Herold, Michael Wolf-Vollenbröker, Patrick Brzoska, Eric Bechler, Timm J Filler
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Abstract

In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a perception of the spatial tensile state of cardiac tissues. The presence and distribution of respective proprioceptive corpuscles have not been considered so far. Therefore, a comprehensive study of the entire human fibrous pericardium was conducted to describe the presence of proprioceptors, their density, and distribution patterns. Eight human pericardial specimens gained from our body donation program were used to create a three-dimensional map of proprioceptors in the pericardium based on their histological and immunohistochemical identification. The 3D map was generated as a volume-rendered 3D model based on magnetic resonance imaging of the pericardium, to which all identified receptors were mapped. To discover a systematic pattern in receptor distribution, statistical cluster analysis was conducted using the Scikit-learn library in Python. Ruffini-like corpuscles (RLCs) were found in all pericardia and assigned to three histological receptor localizations depending on the fibrous pericardium's layering, with no other corpuscular proprioceptors identified. Cluster analysis revealed that RLCs exhibit a specific topographical arrangement. The highest receptor concentrations occur at the ventricular bulges, where their size reaches its maximum in terms of diameter, and at the perivascular pericardial turn-up. The findings suggest that the pericardium is subject to proprioceptive control. RLCs record lateral shearing between the pericardial sublayers, and their distribution pattern enables the detection of distinct dilatation of the heart. Therefore, the pericardium might have an undiscovered function as a sensor with the RLCs as its anatomical correlate.

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人体心包的直觉感受器
在人类机体中,所有功能都受到调节,因此需要一种反馈机制。这种控制涉及对心脏组织空间张力状态的感知。迄今为止,还没有人考虑过各自本体感受体的存在和分布。因此,我们对整个人体纤维心包进行了全面研究,以描述本体感受器的存在、密度和分布模式。根据组织学和免疫组化鉴定,我们利用从遗体捐献计划中获得的八份人体心包标本绘制了心包中本体感受器的三维图。三维图是根据心包的磁共振成像生成的体积渲染三维模型,所有已鉴定的受体都被映射到该模型上。为了发现受体分布的系统模式,使用 Python 中的 Scikit-learn 库进行了统计聚类分析。在所有心包中都发现了拉菲尼样球体(RLC),并根据纤维心包的分层将其归入三种组织学受体定位,没有发现其他球体本体感受器。聚类分析显示,RLCs 呈现出特定的地形排列。受体浓度最高的部位是心室隆起处(其直径达到最大值)和血管周围心包翻起处。研究结果表明,心包受本体感觉控制。RLC 可记录心包亚层之间的横向剪切,其分布模式可检测到心脏的明显扩张。因此,心包可能具有尚未被发现的传感器功能,RLCs 是其解剖学上的相关器官。
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来源期刊
Basic Research in Cardiology
Basic Research in Cardiology 医学-心血管系统
CiteScore
16.30
自引率
5.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology
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