{"title":"The dual nature of T<sub>DC</sub> - bridging dendritic and T cells in immunity.","authors":"Maria Nelli, Mirela Kuka","doi":"10.1002/1873-3468.14998","DOIUrl":null,"url":null,"abstract":"<p><p>T<sub>DC</sub> are hematopoietic cells with unique features that provide intriguing insights into the interplay between innate and adaptive immunity. They express a combination of conventional dendritic cell (DC) and T-cell markers and are found in secondary lymphoid organs (SLOs), lungs and liver of naïve mice, as well as in human blood. When analyzed ex vivo, T<sub>DC</sub> can behave either as DCs or as T cells, depending on the provided stimuli. Notably, T<sub>DC</sub> numbers and activation significantly increase in SLOs following viral infection, suggesting a potential role for T<sub>DC</sub> in antiviral immune responses. In this review, we discuss the properties of these fascinating cells, which call for more investigation on their physiological role during immune responses to both pathogens and tumors.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEBS Letters","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/1873-3468.14998","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
TDC are hematopoietic cells with unique features that provide intriguing insights into the interplay between innate and adaptive immunity. They express a combination of conventional dendritic cell (DC) and T-cell markers and are found in secondary lymphoid organs (SLOs), lungs and liver of naïve mice, as well as in human blood. When analyzed ex vivo, TDC can behave either as DCs or as T cells, depending on the provided stimuli. Notably, TDC numbers and activation significantly increase in SLOs following viral infection, suggesting a potential role for TDC in antiviral immune responses. In this review, we discuss the properties of these fascinating cells, which call for more investigation on their physiological role during immune responses to both pathogens and tumors.
TDC是一种造血细胞，具有独特的特征，为先天性免疫和适应性免疫之间的相互作用提供了引人入胜的见解。它们表达传统树突状细胞（DC）和 T 细胞标记的组合，存在于幼稚小鼠的次级淋巴器官（SLO）、肺和肝脏以及人类血液中。在体外分析时，TDC 可表现为 DC 或 T 细胞，具体取决于所提供的刺激。值得注意的是，病毒感染后，SLO 中的 TDC 数量和活化程度显著增加，这表明 TDC 在抗病毒免疫反应中可能发挥作用。在这篇综述中，我们讨论了这些迷人细胞的特性，这些特性要求对它们在病原体和肿瘤免疫反应中的生理作用进行更多的研究。
期刊介绍：
FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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