Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL Journal of Natural Products Pub Date : 2024-08-23 Epub Date: 2024-08-09 DOI:10.1021/acs.jnatprod.4c00577

Anita Barta, Agostina Salusso, Norbert Kúsz, Róbert Berkecz, Jan Schlauer, Dragica Purger, Judit Hohmann, Maria Cecilia Carpinella, Andrea Vasas

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Abstract

Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes─articulins A-J (1-10)─and ten known compounds─juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11-20)─along with other compounds, have been isolated and identified. The isolated compounds were evaluated for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both bacterial strains) and 15.3 μM (14 for both bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1-114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the antibacterial effect of these compounds.

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具有抗菌和抑制生物膜形成活性的蔺草中的菲族化合物

为了继续寻找君子兰科植物中的生物活性化合物，我们对君子兰进行了研究。研究人员分离并鉴定了十种以前未曾描述过的菲类化合物--节瓜素 A-J （1-10）--和十种已知化合物--节瓜素 B、脱氢节瓜素 B、节瓜素 B、节瓜素 E、F、H、I、K、节瓜素 D 和柚木素 A（11-20）--以及其他化合物。对分离出的化合物进行了抗大肠杆菌、绿脓杆菌、甲氧西林易感金黄色葡萄球菌（MSSA）和甲氧西林耐药金黄色葡萄球菌（MRSA）的抗菌活性评估。化合物 12 和 14 对浮游和无柄 MSSA 和 MRSA 的活性最强，最低抑菌浓度 (MIC) 值分别为 15.1 μM（12 对两种细菌菌株均有效）和 15.3 μM（14 对两种细菌菌株均有效）。化合物 15、17 和 18 对这两种菌株也具有活性，但程度较低，MIC 值在 30.0 到 56.8 μM 之间。这些化合物对生物膜形成的抑制作用在 15.1-114.3 μM 之间。这项研究阐明了菊芋中菲的成分以及这些化合物的抗菌效果。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.