Design and simulation of scaffolds with lattice microstructures for bioprinting bone tissue.

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2024-01-01 DOI:10.3233/BME-230049
Esmeralda Zuñiga-Aguilar, Odin Ramírez-Fernández, Adeodato Botello-Arredondo
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引用次数: 0

Abstract

Background: Tissue engineering seeks to improve, maintain, or replace the biological functions of damaged organs or tissues with biological substitutes such as the development of scaffolds. In the case of bone tissue, they must have excellent mechanical properties like native bone.

Objective: In this work, three geometric models were designed for scaffolds with different structure lattices and porosity that could be biomechanically suitable and support cell growth for trabecular bone replacement applications in tissue engineering and regenerative medicine to the proximal femur area.

Methods: Geometries were designed using computer-aided design (CAD) software and evaluated using finite element analysis in compression tests. Three loads were considered according to the daily activity: 1177 N for slow walking, 2060 N for fast walking, and 245.25 N for a person in a bipedal position. All these loads for an adult weight of 75 kg. For each of them, three biomaterials were assigned: two polymers (poly-glycolic acid (PGA) and poly-lactic acid (PLA)) and one mineral (hydroxyapatite (HA)). 54 tests were performed: 27 for each of the tests.

Results: The results showed Young's modulus (E) between 1 and 4 GPa.

Conclusion: If the resultant E is in the range of 0.1 to 5 GPa, the biomaterial is considered an appropriate alternative for the trabecular bone which is the main component of the proximal bone. However, for the models applied in this study, the best option is the poly-lactic acid which will allow absorbing the acting loads.

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设计和模拟用于生物打印骨组织的具有晶格微结构的支架。
背景:组织工程学旨在通过生物替代品(如支架的开发)来改善、维持或替代受损器官或组织的生物功能。就骨组织而言,它们必须像原生骨一样具有出色的机械性能:在这项工作中,我们设计了三种几何模型,它们具有不同的结构晶格和孔隙率,在生物力学上适合并支持细胞生长,可用于组织工程和再生医学中的股骨近端骨小梁替代应用:使用计算机辅助设计(CAD)软件设计几何形状,并在压缩试验中使用有限元分析进行评估。根据日常活动考虑了三种载荷:慢走为 1177 牛顿,快走为 2060 牛顿,双足站立为 245.25 牛顿。所有这些载荷都是以成人体重 75 千克为基准。为每种负载指定了三种生物材料:两种聚合物(聚羟基乙酸(PGA)和聚乳酸(PLA))和一种矿物质(羟基磷灰石(HA))。共进行了 54 次测试:每次测试 27 次:结果显示杨氏模量(E)在 1 到 4 GPa 之间:结论:如果得出的 E 值在 0.1 到 5 GPa 之间,生物材料被认为是骨小梁的合适替代材料,而骨小梁是近端骨骼的主要组成部分。不过,就本研究中应用的模型而言,最佳选择是聚乳酸,它可以吸收作用载荷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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