The Impact of Childhood Trauma on the Negative Symptoms of Schizophrenia.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Journal of Nervous and Mental Disease Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI:10.1097/NMD.0000000000001788
Katelyn Ware, Blazej Misiak, Eid Abo Hamza, Shahad Nalla, Ahmed A Moustafa
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Abstract

Abstract: Schizophrenia is a debilitating mental health disorder that imposes profound economic, societal, and personal burdens. The negative symptoms of schizophrenia ( i.e. , blunted affect, alogia, anhedonia, asociality, and avolition) are highly prevalent and pervasive in the psychotic disorder and pose significant resistance to available treatment options. Traumatic childhood experiences are strongly linked with the risk of developing schizophrenia. Most prior studies have primarily focused on positive symptoms of schizophrenia ( e.g. , hallucinations and delusions), whereas less attention has been given to negative symptoms. The current study investigated the relationship between childhood trauma ( i.e. , physical abuse, sexual abuse, and emotional abuse and neglect) and negative symptoms in a sample of schizophrenia outpatients and healthy controls ( n = 159 participants, including 99 patients with schizophrenia). The observations from the current study revealed that schizophrenia patients experienced a significantly greater degree of childhood trauma and negative symptoms than the control individuals. The results of the current study also indicated that more severe experiences of total childhood trauma ( i.e. , summation of all trauma types), physical abuse, and emotional neglect may increase the risk of schizophrenia patients reporting negative symptoms. However, childhood sexual and emotional abuse was found to have no impact on the degree of negative symptoms experienced by schizophrenia patients. Implications and limitations of the current study are discussed. In conclusion, we found that the severity of overall childhood trauma, physical abuse, and emotional neglect may play an important role in increasing the likelihood of schizophrenia patients reporting negative symptoms.

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童年创伤对精神分裂症阴性症状的影响》(The Impact of Childhood Trauma on the Negative Symptoms of Schizophrenia)。
摘要:精神分裂症是一种使人衰弱的精神疾病,给经济、社会和个人带来沉重负担。精神分裂症的阴性症状(即情感迟钝、失眠、失张力、不合群和逃避现实)在精神障碍中非常普遍和常见,对现有的治疗方案造成了巨大的阻力。童年的创伤经历与患精神分裂症的风险密切相关。之前的大多数研究主要关注精神分裂症的阳性症状(如幻觉和妄想),而对阴性症状关注较少。本研究调查了精神分裂症门诊患者和健康对照组样本(n = 159 人,其中包括 99 名精神分裂症患者)中童年创伤(即身体虐待、性虐待、情感虐待和忽视)与阴性症状之间的关系。本次研究的观察结果显示,精神分裂症患者经历的童年创伤和阴性症状程度明显高于对照组。本次研究的结果还表明,童年总体创伤(即所有创伤类型的总和)、身体虐待和情感忽视的经历越严重,精神分裂症患者出现阴性症状的风险就越高。然而,研究发现童年性虐待和情感虐待对精神分裂症患者阴性症状的程度没有影响。本文讨论了本研究的意义和局限性。总之,我们发现童年时期的整体创伤、身体虐待和情感忽视的严重程度可能会在增加精神分裂症患者出现阴性症状的可能性方面发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
5.30%
发文量
233
审稿时长
3-8 weeks
期刊介绍: The Journal of Nervous and Mental Disease publishes peer-reviewed articles containing new data or ways of reorganizing established knowledge relevant to understanding and modifying human behavior, especially that defined as impaired or diseased, and the context, applications and effects of that knowledge. Our policy is summarized by the slogan, "Behavioral science for clinical practice." We consider articles that include at least one behavioral variable, clear definition of study populations, and replicable research designs. Authors should use the active voice and first person whenever possible.
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