Leisure television watching exerts a causal effect on gastroesophageal reflux disease: evidence from a two-step mendelian randomization study.

IF 2.1 4区 医学 Q3 GENETICS & HEREDITY BMC Medical Genomics Pub Date : 2024-08-09 DOI:10.1186/s12920-024-01986-5
Qinglu Fan, Zhihao Nie, Yi Lu, Songping Xie
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Abstract

Background: Previous studies have shown that physical activity (PA) and leisure sedentary behaviors (LSB, including leisure television watching) are linked to gastroesophageal reflux disease (GERD). However, the associations between PA/LSB and GERD remain controversial. In this study, we aimed to reveal whether these associations reflect causal relationships and reveal the potential mechanisms of these relationships using bidirectional and two-step Mendelian randomization (MR) analyses.

Methods: We obtained genome-wide association study (GWAS) summary statistics for PA/LSB, four common risk factors (including cigarettes smoked per day, alcoholic drinks per week, triglycerides, total cholesterol) and GERD from published GWASs. A bidirectional MR analysis was performed to identify causal relationships between PA/LSB and GERD. Then, a series of sensitivity analyses were performed to verify the robustness of the results. Finally, a mediation analysis via two-step MR was conducted to investigate any effects explained by common risk factors in these relationships.

Results: Genetically predicted per 1-SD increase in leisure time television watching significantly increased the risk of GERD in the bidirectional MR analysis (OR = 1.33; 95% CI: 1.14-1.56; P = 2.71 × 10- 4). Sensitivity analyses successfully verified the robustness of the causal relationship. Further mediation analysis showed that this effect was partly mediated by increasing cigarettes smoked per day, with mediated proportions of 18.37% (95% CI: 11.94-39.79%).

Conclusion: Our findings revealed a causal relationship between leisure television watching and an increased risk of GERD, notably, the causal effect was partially mediated by cigarettes smoked per day. These findings may inform prevention and management strategies directed toward GERD.

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休闲看电视对胃食管反流病有因果效应:来自两步孟德尔随机研究的证据。
背景:以往的研究表明,体力活动(PA)和休闲久坐行为(LSB,包括休闲看电视)与胃食管反流病(GERD)有关。然而,PA/LSB 与胃食管反流病之间的关系仍存在争议。在本研究中,我们旨在通过双向和两步孟德尔随机(MR)分析,揭示这些关联是否反映了因果关系,并揭示这些关系的潜在机制:我们从已发表的全基因组关联研究(GWAS)中获得了 PA/LSB、四种常见风险因素(包括每天吸烟、每周饮酒、甘油三酯、总胆固醇)和胃食管反流病的汇总统计数据。为了确定 PA/LSB 与胃食管反流病之间的因果关系,我们进行了双向 MR 分析。然后,进行了一系列敏感性分析,以验证结果的稳健性。最后,通过两步MR进行了中介分析,以研究这些关系中共同风险因素所解释的任何影响:结果:在双向 MR 分析中,闲暇时间看电视的基因预测值每增加 1-SD 会显著增加胃食管反流病的风险(OR = 1.33;95% CI:1.14-1.56;P = 2.71 × 10-4)。敏感性分析成功验证了因果关系的稳健性。进一步的中介分析表明,日吸烟量的增加在一定程度上中介了这一效应,中介比例为 18.37% (95% CI: 11.94-39.79%):我们的研究结果表明,休闲时看电视与胃食管反流病风险增加之间存在因果关系,值得注意的是,这种因果效应部分受到每天吸烟量的影响。这些发现可为胃食管反流病的预防和管理策略提供参考。
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来源期刊
BMC Medical Genomics
BMC Medical Genomics 医学-遗传学
CiteScore
3.90
自引率
0.00%
发文量
243
审稿时长
3.5 months
期刊介绍: BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
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