Initiation and outcomes of women pursuing planned fertility preservation.

IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Fertility and sterility Pub Date : 2025-01-01 Epub Date: 2024-08-08 DOI:10.1016/j.fertnstert.2024.08.312
David Boedeker, Marja Brolinson, Alexandra C Campedelli, Rona Yu, Sorana Raiciulescu, Kate Devine, Micah Hill, Alan DeCherney, Trimble Spitzer
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Abstract

Objective: To study cycle outcomes of women who choose to pursue oocyte cryopreservation, using published age-specific oocyte recommendations.

Design: Retrospective cohort.

Setting: Clinic.

Patient(s): A total of 5,915 patients seeking planned oocyte cryopreservation, 3,504 ultimately underwent ovarian stimulation with oocyte retrieval and cryopreservation, 425 of this cohort subsequently thawed with intent to use embryo transfer.

Exposure: Planned oocyte cryopreservation.

Main outcome measure(s): Planned oocyte cryopreservation consultation, fertility preservation cycle(s) and ovarian stimulation outcomes.

Result(s): A total of 5,915 women were seen in the initial consultation for planned fertility preservation (2012-2022). Ethnicity and the highest level of education were significant in predicting who would move forward with oocyte stimulation for fertility preservation. Women who reported working within the law and public policy and in the fields of health and medicine were statistically more likely to proceed with a cycle than those who listed other occupations. Of 3,504 women in the study cohort who underwent ovarian stimulation and egg retrieval, 1,331 (38.0%) achieved the age-based recommended number of oocytes to freeze. Only 57 (4.3%) of these women who met their age-based oocyte goal did so after their initial cryopreservation cycle. There was a significant association between ethnicity and number of cryopreservation cycles, specifically showing that Black or African American women were less likely to complete two or more cycles. Patients whose education background included graduate or professional degrees were more likely to have completed more than one cycle.

Conclusion(s): Self-identified ethnicity was significantly associated with the odds of moving forward with oocyte stimulation for fertility preservation and egg retrieval after initial consultation with ethnic minorities significantly less likely to continue treatment. Of those who undergo egg freezing, most women pursue more than one stimulation and cryopreservation cycle, yet the majority never meet their recommended number to freeze.

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计划保留生育能力的妇女的启动和结果。
目的根据已公布的特定年龄段卵母细胞建议,研究选择进行卵母细胞冷冻保存的女性的周期结果 设计:回顾性队列 研究对象: 5915 名寻求计划进行卵母细胞冷冻保存的患者:共有 5915 名患者计划进行卵母细胞冷冻保存,其中 3504 人最终进行了卵巢刺激、卵母细胞提取和冷冻保存,其中 425 人随后进行了解冻,并打算进行胚胎移植:计划的卵母细胞冷冻主要结果测量:计划卵母细胞冷冻咨询、生育力保存周期和卵巢刺激结果 结果:5915 名女性接受了计划生育力保存的初步咨询(2012-2022 年)。种族和最高教育水平对预测谁会为保存生育力而进行卵母细胞刺激具有重要意义。据统计,在法律和公共政策领域以及健康和医学领域工作的女性比从事其他职业的女性更有可能进行周期治疗(P < 0.001)。研究队列中有 3504 名妇女接受了卵巢刺激和取卵,其中有 1331 人(38.0%)达到了根据年龄建议的卵母细胞冷冻数量。其中只有 57 名(4.3%)妇女在首次冷冻周期后达到了按年龄计算的卵母细胞目标。种族与冷冻保存周期数之间存在明显关联,具体表现为黑人或非裔美国妇女完成两个或更多周期的可能性较低(p < 0.001)。教育背景包括研究生或专业学位的患者更有可能完成一个以上的周期(p = 0.007):自我认同的种族与初次咨询后继续进行卵母细胞刺激以保留生育力和取卵的几率有很大关系(p
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来源期刊
Fertility and sterility
Fertility and sterility 医学-妇产科学
CiteScore
11.30
自引率
6.00%
发文量
1446
审稿时长
31 days
期刊介绍: Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.
期刊最新文献
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