Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.06.023
<div><h3>Objective</h3><div>To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.</div></div><div><h3>Design</h3><div>A retrospective cohort study.</div></div><div><h3>Setting</h3><div>A private human reproduction center.</div></div><div><h3>Patient(s)</h3><div>A total of 267 couples underwent intracytoplasmic sperm injections between January 2017 and March 2019.</div></div><div><h3>Intervention(s)</h3><div>The couples were categorized into four groups on the basis of 25-hydroxy VD (25OHD) levels measured at the beginning of the stimulation protocol: group 1 with 25OHD levels <strong>≥</strong>30 ng/mL for both women and men; group 2 with 25OHD levels <30 ng/mL for both; group 3 women with 25OHD levels <30 ng/mL and men with 25OHD levels ≥30 ng/mL; and group 4 with women with 25OHD level <strong>≥</strong>30 ng/mL and men with 25OHD level <30 ng/mL.</div></div><div><h3>Main Outcome Measure(s)</h3><div>We consider the quantity and quality of embryos during the cleavage as well as blastocyst stages as primary outcomes. Correspondingly, the clinical pregnancy rate (CPR) was regarded as a secondary outcome.</div></div><div><h3>Result(s)</h3><div>Our findings revealed no significant correlations between the studied VD groups and the evaluated outcomes. This includes the quantity and quality of embryos during the cleavage and blastocyst stages, as well as the CPR. Primary analysis revealed a small but statistically significant difference in the duration of controlled ovarian stimulation between group 1 and group 2 (95% confidence interval, 0.07–3.04) and between group 1 and group 3 (95% confidence interval, 0.05–3.23).</div></div><div><h3>Conclusion(s)</h3><div>The present study found no correlation between the studied VD levels and the quantity as well as quality of cleavage or blastocyst stage embryos, nor did it show any impact on CPRs. Further well-designed, prospective studies are warranted to determine whether and how vitamin D affects reproductive outcomes.</div></div><div><div>Niveles de vitamina D en parejas sometidas a tratamiento de fecundación in vitro: falta de asociación con la calidad del embrión o las tasas de embarazo</div></div><div><h3>Objetivo</h3><div>Investigar el impacto potencial de los niveles séricos de vitamina D (VD) en parejas que se someten a un tratamiento de fertilización in vitro en términos de calidad embrionaria y tasas de embarazo.</div></div><div><h3>Diseño</h3><div>Estudio de cohorte retrospectivo.</div></div><div><h3>Lugar</h3><div>Centro privado de reproducción humana.</div></div><div><h3>Paciente(s)</h3><div>Un total de 267 parejas se sometieron a inyecciones intracitoplasmáticas de espermatozoides entre enero de 2017 y marzo de 2019.</div></div><div><h3>Intervención(es)</h3><div>Las parejas se clasificaron en cuatro grupos en función de los niveles de 25-hidroxi VD (25OHD) medidos al i
目的:研究维生素 D 血清水平对试管受精夫妇胚胎质量和妊娠率的潜在影响:调查维生素 D 血清水平对试管受精夫妇胚胎质量和妊娠率的潜在影响:设计:回顾性队列研究:受试者:2017年1月至2019年3月期间接受卵胞浆内单精子注射的267对夫妇。暴露:根据刺激方案开始时测量的25OH维生素D水平,将夫妇分为四组:第1组,男女双方水平均≥30纳克/毫升;第2组,男女双方水平均<30纳克/毫升;第3组,女性<30纳克/毫升,男性≥30纳克/毫升;第4组,女性≥30纳克/毫升,男性<30纳克/毫升.主要结果测量:我们将分裂期和囊胚期胚胎的数量和质量作为主要结果。相应地,临床妊娠率被视为次要结果:结果:我们的研究结果表明,所研究的 VD 组与评估结果之间没有明显的相关性。结果:我们的研究结果表明,所研究的 VD 组与评估结果之间没有明显的相关性,包括胚胎在分裂期和囊胚期的数量和质量,以及临床妊娠率。初步分析显示,第 1 组和第 2 组(P=0.035;CI=0.07 - 3.04)以及第 1 组和第 3 组(P=0.040;CI=0.05 - 3.23)之间的控制性卵巢刺激持续时间差异较小,但具有统计学意义:本研究发现,所研究的 VD 水平与卵裂期或囊胚期胚胎的数量和质量之间没有相关性,对临床妊娠率也没有任何影响。有必要进一步开展精心设计的前瞻性研究,以确定维生素 D 是否以及如何影响生殖结果。
{"title":"Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates","authors":"","doi":"10.1016/j.fertnstert.2024.06.023","DOIUrl":"10.1016/j.fertnstert.2024.06.023","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.</div></div><div><h3>Design</h3><div>A retrospective cohort study.</div></div><div><h3>Setting</h3><div>A private human reproduction center.</div></div><div><h3>Patient(s)</h3><div>A total of 267 couples underwent intracytoplasmic sperm injections between January 2017 and March 2019.</div></div><div><h3>Intervention(s)</h3><div>The couples were categorized into four groups on the basis of 25-hydroxy VD (25OHD) levels measured at the beginning of the stimulation protocol: group 1 with 25OHD levels <strong>≥</strong>30 ng/mL for both women and men; group 2 with 25OHD levels <30 ng/mL for both; group 3 women with 25OHD levels <30 ng/mL and men with 25OHD levels ≥30 ng/mL; and group 4 with women with 25OHD level <strong>≥</strong>30 ng/mL and men with 25OHD level <30 ng/mL.</div></div><div><h3>Main Outcome Measure(s)</h3><div>We consider the quantity and quality of embryos during the cleavage as well as blastocyst stages as primary outcomes. Correspondingly, the clinical pregnancy rate (CPR) was regarded as a secondary outcome.</div></div><div><h3>Result(s)</h3><div>Our findings revealed no significant correlations between the studied VD groups and the evaluated outcomes. This includes the quantity and quality of embryos during the cleavage and blastocyst stages, as well as the CPR. Primary analysis revealed a small but statistically significant difference in the duration of controlled ovarian stimulation between group 1 and group 2 (95% confidence interval, 0.07–3.04) and between group 1 and group 3 (95% confidence interval, 0.05–3.23).</div></div><div><h3>Conclusion(s)</h3><div>The present study found no correlation between the studied VD levels and the quantity as well as quality of cleavage or blastocyst stage embryos, nor did it show any impact on CPRs. Further well-designed, prospective studies are warranted to determine whether and how vitamin D affects reproductive outcomes.</div></div><div><div>Niveles de vitamina D en parejas sometidas a tratamiento de fecundación in vitro: falta de asociación con la calidad del embrión o las tasas de embarazo</div></div><div><h3>Objetivo</h3><div>Investigar el impacto potencial de los niveles séricos de vitamina D (VD) en parejas que se someten a un tratamiento de fertilización in vitro en términos de calidad embrionaria y tasas de embarazo.</div></div><div><h3>Diseño</h3><div>Estudio de cohorte retrospectivo.</div></div><div><h3>Lugar</h3><div>Centro privado de reproducción humana.</div></div><div><h3>Paciente(s)</h3><div>Un total de 267 parejas se sometieron a inyecciones intracitoplasmáticas de espermatozoides entre enero de 2017 y marzo de 2019.</div></div><div><h3>Intervención(es)</h3><div>Las parejas se clasificaron en cuatro grupos en función de los niveles de 25-hidroxi VD (25OHD) medidos al i","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.06.004
This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors, as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. This revised document incorporates recent information from the US Centers for Disease Control and Prevention, the US Food and Drug Administration, and the American Association of Tissue Banks, with which all programs offering gamete and embryo donation services must be thoroughly familiar, and replaces the document titled ”Recommendations for gamete and embryo donation: a committee opinion,” last published in 2013.
Guía para la donación de gametos y embriones
Este documento proporciona las recomendaciones más recientes para el estudio de candidatos a donación de semen, de ovocitos y de embriones, así como de sus receptores, incorporando información actualizada sobre el cribado y las pruebas óptimas para enfermedades de transmisión sexual, genéticas y evaluaciones psicológicas. Este documento revisado incluye información reciente de los Centros para el Control y la Prevención de Enfermedades de EE. UU., la Administración de Alimentos y Medicamentos de EE. UU. y la Asociación Americana de Bancos de Tejidos, con la cual todos los programas que ofrezcan servicios de donación de gametos y embriones deben estar completamente familiarizados. Este documento reemplaza al titulado "Recomendaciones para la donación de gametos y embriones: una opinión del comité", publicado por última vez en 2013.
本文件提供了对潜在精子、卵细胞和胚胎捐献者及其受捐者进行评估的最新建议,纳入了有关性传播感染、遗传疾病和心理评估的最佳筛查和检测的最新信息。这份修订版文件纳入了美国疾病控制与预防中心、美国食品和药物管理局以及美国组织库协会(American Association of Tissue Banks)提供的最新信息,所有提供配子和胚胎捐献服务的项目都必须充分熟悉这些信息,并取代了 2013 年发布的《配子和胚胎捐献建议:委员会意见》。
{"title":"Gamete and embryo donation guidance","authors":"","doi":"10.1016/j.fertnstert.2024.06.004","DOIUrl":"10.1016/j.fertnstert.2024.06.004","url":null,"abstract":"<div><div>This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors, as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. This revised document incorporates recent information from the US Centers for Disease Control and Prevention, the US Food and Drug Administration, and the American Association of Tissue Banks, with which all programs offering gamete<span> and embryo donation services must be thoroughly familiar, and replaces the document titled ”Recommendations for gamete and embryo donation: a committee opinion,” last published in 2013.</span></div></div><div><div>Guía para la donación de gametos y embriones</div><div>Este documento proporciona las recomendaciones más recientes para el estudio de candidatos a donación de semen, de ovocitos y de embriones, así como de sus receptores, incorporando información actualizada sobre el cribado y las pruebas óptimas para enfermedades de transmisión sexual, genéticas y evaluaciones psicológicas. Este documento revisado incluye información reciente de los Centros para el Control y la Prevención de Enfermedades de EE. UU., la Administración de Alimentos y Medicamentos de EE. UU. y la Asociación Americana de Bancos de Tejidos, con la cual todos los programas que ofrezcan servicios de donación de gametos y embriones deben estar completamente familiarizados. Este documento reemplaza al titulado \"Recomendaciones para la donación de gametos y embriones: una opinión del comité\", publicado por última vez en 2013.</div></div>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.07.496
Milena Sophie Alec , Jonas Jean Mathieu Vibert , Fabian Grass M.D. , Nicola Pluchino M.D., Ph.D
<div><h3>Objective</h3><div>To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving.</div></div><div><h3>Design</h3><div>Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule.</div></div><div><h3>Setting</h3><div>Lausanne University Hospital and Geneva University Hospital.</div></div><div><h3>Patient(s)</h3><div>Two women with symptomatic endometriosis rectal lesion.</div></div><div><h3>Intervention(s)</h3><div>Preoperative transvaginal ultrasound was performed to measure the rectal nodule. After completing bowel shaving, the surgeon conducted both clinical and sonographic evaluations of the rectal wall. Clinically, this was performed using laparoscopic grasping forceps and sonographically with a transvaginal probe after filling the pelvis with saline solution.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Assessment of the rectal wall for residual disease after bowel shaving and evaluation of the necessity for additional bowel resection.</div></div><div><h3>Result(s)</h3><div>After sonographic evaluation of the rectal wall, the surgeon decided in both patients to perform a discoid resection because of the presence of a residual rectal disease despite thorough bowel shaving.</div></div><div><h3>Conclusion(s)</h3><div>Intraoperative transvaginal ultrasound after bowel endometriosis shaving is a promising technique that is safe, reproducible, and efficient. It aids surgeons in accurately assessing the extent of excision of deep rectosigmoid infiltrating endometriosis and determining the necessity of additional bowel resection to reduce recurrence risk. Moreover, intraoperative ultrasound provides precise measurements of residual nodules, enabling differentiation between persistent, recurrent, or new lesions during follow-up.</div></div><div><div>Uso del Ultrasonido transvaginal intraoperatorio para estandarizar la resección de la endometriosis intestinal</div></div><div><h3>Objetivo</h3><div>Estudiar el uso del ultrasonido transvaginal intraoperatorio después de la resección de la endometriosis intestinal.</div></div><div><h3>Diseño</h3><div>Demostración paso a paso con un video narrado del uso preoperatorio e intraoperatorio del ultrasonido transvaginal en la evaluación de la extensión de un nódulo rectal endometriósico.</div></div><div><h3>Lugar</h3><div>Hospital Universitario de Lausana y Hospital Universitario de Ginebra.</div></div><div><h3>Paciente(s)</h3><div>Dos pacientes con endometriosis intomática rectal.</div></div><div><h3>Intervención(es)</h3><div>Se realizó ecografía transvaginal preoperatoria para medir el nódulo rectal. Después de completar la resección intestinal, el cirujano realizó evaluaciones clínicas y ecográficas de la pared rectal. Clínicamente, esto se realizó usando fórceps de agarre laparoscópico y ecográficamente con una sonda transvaginal después de llenar la pelvis con soluc
{"title":"Intraoperative transvaginal ultrasound to standardize bowel endometriosis shaving","authors":"Milena Sophie Alec , Jonas Jean Mathieu Vibert , Fabian Grass M.D. , Nicola Pluchino M.D., Ph.D","doi":"10.1016/j.fertnstert.2024.07.496","DOIUrl":"10.1016/j.fertnstert.2024.07.496","url":null,"abstract":"<div><h3>Objective</h3><div>To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving.</div></div><div><h3>Design</h3><div>Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule.</div></div><div><h3>Setting</h3><div>Lausanne University Hospital and Geneva University Hospital.</div></div><div><h3>Patient(s)</h3><div>Two women with symptomatic endometriosis rectal lesion.</div></div><div><h3>Intervention(s)</h3><div>Preoperative transvaginal ultrasound was performed to measure the rectal nodule. After completing bowel shaving, the surgeon conducted both clinical and sonographic evaluations of the rectal wall. Clinically, this was performed using laparoscopic grasping forceps and sonographically with a transvaginal probe after filling the pelvis with saline solution.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Assessment of the rectal wall for residual disease after bowel shaving and evaluation of the necessity for additional bowel resection.</div></div><div><h3>Result(s)</h3><div>After sonographic evaluation of the rectal wall, the surgeon decided in both patients to perform a discoid resection because of the presence of a residual rectal disease despite thorough bowel shaving.</div></div><div><h3>Conclusion(s)</h3><div>Intraoperative transvaginal ultrasound after bowel endometriosis shaving is a promising technique that is safe, reproducible, and efficient. It aids surgeons in accurately assessing the extent of excision of deep rectosigmoid infiltrating endometriosis and determining the necessity of additional bowel resection to reduce recurrence risk. Moreover, intraoperative ultrasound provides precise measurements of residual nodules, enabling differentiation between persistent, recurrent, or new lesions during follow-up.</div></div><div><div>Uso del Ultrasonido transvaginal intraoperatorio para estandarizar la resección de la endometriosis intestinal</div></div><div><h3>Objetivo</h3><div>Estudiar el uso del ultrasonido transvaginal intraoperatorio después de la resección de la endometriosis intestinal.</div></div><div><h3>Diseño</h3><div>Demostración paso a paso con un video narrado del uso preoperatorio e intraoperatorio del ultrasonido transvaginal en la evaluación de la extensión de un nódulo rectal endometriósico.</div></div><div><h3>Lugar</h3><div>Hospital Universitario de Lausana y Hospital Universitario de Ginebra.</div></div><div><h3>Paciente(s)</h3><div>Dos pacientes con endometriosis intomática rectal.</div></div><div><h3>Intervención(es)</h3><div>Se realizó ecografía transvaginal preoperatoria para medir el nódulo rectal. Después de completar la resección intestinal, el cirujano realizó evaluaciones clínicas y ecográficas de la pared rectal. Clínicamente, esto se realizó usando fórceps de agarre laparoscópico y ecográficamente con una sonda transvaginal después de llenar la pelvis con soluc","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.08.336
Daniela Diego M.D., Heather S. Hipp M.D.
{"title":"Oocyte cryopreservation: setting appropriate “eggs-pectations”","authors":"Daniela Diego M.D., Heather S. Hipp M.D.","doi":"10.1016/j.fertnstert.2024.08.336","DOIUrl":"10.1016/j.fertnstert.2024.08.336","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.06.017
<div><h3>Objective</h3><div>To evaluate donor gamete utilization, patient satisfaction, and fertility treatment outcomes of patients pursuing treatment with donor gametes stratified by the desired race as well as ethnicity of the gamete donor.</div></div><div><h3>Design</h3><div>Survey study.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>Patients planning to undergo treatment using donor sperm and/or donor oocytes at a single academic fertility clinic in the Southeastern United States between 2015 and 2020.</div></div><div><h3>Intervention(s)</h3><div>None.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Utilization rates of donor gametes, satisfaction with donor gamete selection, and fertility treatment outcomes stratified by race and ethnicity of patient, as well as that of their gamete donor.</div></div><div><h3>Result(s)</h3><div>Four hundred fifty patients were eligible for inclusion and 170 (38%) responded to the survey. Among the respondents, 59% desired a non-Hispanic White gamete donor and 20% desired a non-Hispanic Black gamete donor. Patients seeking a non-Hispanic Black gamete donor had lower odds of using donor gametes (Odds ratio [OR], 0.13; 95% confidence interval [CI], 0.04–0.40) compared with individuals seeking a non-Hispanic White gamete donor. When evaluating satisfaction with donor gamete selection, patients seeking a non-Hispanic Black gamete donor reported lower satisfaction compared with individuals seeking a non-Hispanic White gamete donor (OR, 0.19; 95% CI, 0.09–0.43). When evaluating fertility outcomes, Non-Hispanic Black patients and those using non-Hispaninc Black gamete donors were found to have lower odds of successful conception compared with non-Hispanic White patients (OR, 0.18; 95% CI, 0.07–0.46) and individuals seeking non-Hispanic White gamete donors (OR, 0.26; 95% CI, 0.09–0.75), respectively.</div></div><div><h3>Conclusion(s)</h3><div>Patients seeking non-Hispanic Black donor gametes have lower utilization rates, less satisfaction with gamete donor selection, and lower odds of conception when compared with those seeking non-Hispanic White gamete donors. These findings highlight the need for more racial diversity within donor gamete banks, as well as within the donor pools available through agencies and fertility clinics.</div></div><div><div>Un estudio de encuesta evaluando tasas de utilización de gametos donados, satisfacción del paciente, y resultados de tratamientos de fertilidad de acuerdo a la raza y etnicidad deseada</div></div><div><h3>Objetivo</h3><div>Evaluar la utilización de los gametos donados, satisfacción del paciente, y los resultados de pacientes que siguen un tratamiento con donantes de gametos estratificados por la raza deseada así como la etnicidad del donante de gametos.</div></div><div><h3>Diseño</h3><div>Estudio de encuesta.</div></div><div><h3>Lugar</h3><div>Clínica.</div></div><div><h3>Paciente (s)</h3><div>Pacientes planeando seguir un trat
目的根据配子捐献者所希望的种族和民族,评估使用配子捐献者治疗的患者的配子捐献情况、患者满意度和生育治疗结果:调查研究 对象:2015年至2020年期间,计划在美国东南部一家学术性生殖诊所接受捐献精子和/或捐献卵细胞治疗的患者:按患者及其配子捐献者的种族和民族划分的捐献配子使用率、对捐献配子选择的满意度和生育治疗结果:共有 450 名患者符合调查条件,其中 170 人(38%)接受了调查。其中,59%的受访者希望获得非西班牙裔白人配子捐献者,20%希望获得非西班牙裔黑人配子捐献者。与寻求非西班牙裔白人配子捐献者相比,寻求非西班牙裔黑人配子捐献者的患者使用配子捐献者的几率较低(OR = 0.13,95% CI 0.04 - 0.40)。在评估配子捐献者选择满意度时,与寻求非西班牙裔白人配子捐献者的患者相比,寻求非西班牙裔黑人配子捐献者的患者满意度较低(OR 0.19,95% CI [0.09-0.43])。在评估生育结果时发现,与非西班牙裔白人患者(OR=0.18,95% CI 0.07-0.46)和寻求非西班牙裔白人配子捐献者(OR=0.26,95% CI 0.09-0.75)相比,非西班牙裔黑人患者和利用非西班牙裔黑人配子捐献者成功受孕的几率较低:结论:与寻求非西班牙裔白人配子捐献者相比,寻求非西班牙裔黑人配子捐献者的患者利用率较低,对配子捐献者选择的满意度较低,受孕几率也较低。这些研究结果突出表明,配子捐献者库以及机构和生育诊所提供的捐献者库中需要更多的种族多样性。
{"title":"A survey study evaluating donor gamete utilization rates, patient satisfaction, and fertility treatment outcomes according to desired race and ethnicity","authors":"","doi":"10.1016/j.fertnstert.2024.06.017","DOIUrl":"10.1016/j.fertnstert.2024.06.017","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate donor gamete utilization, patient satisfaction, and fertility treatment outcomes of patients pursuing treatment with donor gametes stratified by the desired race as well as ethnicity of the gamete donor.</div></div><div><h3>Design</h3><div>Survey study.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>Patients planning to undergo treatment using donor sperm and/or donor oocytes at a single academic fertility clinic in the Southeastern United States between 2015 and 2020.</div></div><div><h3>Intervention(s)</h3><div>None.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Utilization rates of donor gametes, satisfaction with donor gamete selection, and fertility treatment outcomes stratified by race and ethnicity of patient, as well as that of their gamete donor.</div></div><div><h3>Result(s)</h3><div>Four hundred fifty patients were eligible for inclusion and 170 (38%) responded to the survey. Among the respondents, 59% desired a non-Hispanic White gamete donor and 20% desired a non-Hispanic Black gamete donor. Patients seeking a non-Hispanic Black gamete donor had lower odds of using donor gametes (Odds ratio [OR], 0.13; 95% confidence interval [CI], 0.04–0.40) compared with individuals seeking a non-Hispanic White gamete donor. When evaluating satisfaction with donor gamete selection, patients seeking a non-Hispanic Black gamete donor reported lower satisfaction compared with individuals seeking a non-Hispanic White gamete donor (OR, 0.19; 95% CI, 0.09–0.43). When evaluating fertility outcomes, Non-Hispanic Black patients and those using non-Hispaninc Black gamete donors were found to have lower odds of successful conception compared with non-Hispanic White patients (OR, 0.18; 95% CI, 0.07–0.46) and individuals seeking non-Hispanic White gamete donors (OR, 0.26; 95% CI, 0.09–0.75), respectively.</div></div><div><h3>Conclusion(s)</h3><div>Patients seeking non-Hispanic Black donor gametes have lower utilization rates, less satisfaction with gamete donor selection, and lower odds of conception when compared with those seeking non-Hispanic White gamete donors. These findings highlight the need for more racial diversity within donor gamete banks, as well as within the donor pools available through agencies and fertility clinics.</div></div><div><div>Un estudio de encuesta evaluando tasas de utilización de gametos donados, satisfacción del paciente, y resultados de tratamientos de fertilidad de acuerdo a la raza y etnicidad deseada</div></div><div><h3>Objetivo</h3><div>Evaluar la utilización de los gametos donados, satisfacción del paciente, y los resultados de pacientes que siguen un tratamiento con donantes de gametos estratificados por la raza deseada así como la etnicidad del donante de gametos.</div></div><div><h3>Diseño</h3><div>Estudio de encuesta.</div></div><div><h3>Lugar</h3><div>Clínica.</div></div><div><h3>Paciente (s)</h3><div>Pacientes planeando seguir un trat","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.07.008
<div><h3>Objective</h3><div>To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) platform.</div></div><div><h3>Design</h3><div>Retrospective observational study performed between 2020 and 2022.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>A total of 12,157 patients who underwent clinical PGT-A performed by targeted next-generation sequencing for whole chromosome and large segmental aneuploidies.</div></div><div><h3>Intervention(s)</h3><div>An incidental finding was reported when a CNV gain/loss of at least 3 consecutive amplicons appeared in at least 2 embryos from the same in vitro fertilization cycle.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary outcome measures were the specificity, incidence, inheritance, and pathogenicity of small CNVs detected by the PGT-A platform. Accuracy of the PGT-A platform CNV calls was assessed via concordance with the CNV calls (size and genomic location) on chromosomal microarray of the gamete provider(s). Parental origin of the CNV and pathogenicity classifications were also reported.</div></div><div><h3>Result(s)</h3><div>An incidental finding that met reporting criteria was identified in 75 (0.62%; 95% confidence interval, 0.5%–0.8%) of 12,157 unique PGT-A patients. Chromosomal microarray follow-up was requested for all cases, and results were received for 1 or both members of 65 reproductive couples. In all cases, 1 of the gamete providers was confirmed to have the CNV identified in the embryos (100.0%, N = 65/65; 95% confidence interval, 94.5–100). The identified CNV was of maternal origin in 34 cases (52.3%) and of paternal origin in 31 cases (47.7%). A significant correlation was identified between PGT-A–predicted CNV sizes and chromosomal microarray detected sizes (r = 0.81) and genomic coordinates on parental deoxyribonucleic acid. Twenty-six (40%) of the CNVs were classified as benign/likely benign, 30 (46.2%) as a variant of uncertain significance, and 9 (13.8%) as pathogenic/likely pathogenic.</div></div><div><h3>Conclusion(s)</h3><div>Certain PGT-A platforms may enable the detection of inherited, small CNVs with extremely high specificity without prior knowledge of parental status. Most CNVs in this data set were confirmed to be benign/likely benign or a variant of uncertain significance. Pathogenic/likely pathogenic CNVs associated with a broad range of phenotypic features may also be detected, although a reliable negative predictive value for small CNVs with current PGT-A technologies is unknown because of the many technical challenges.</div></div><div><div>Confirmación y patogenicidad de pequeñas variaciones en el número de copias detectadas incidentalmente mediante una plataforma de pruebas genéticas preimplantacionales para aneuploidía basada en secuenciación de próxima generaci
{"title":"Confirmation and pathogenicity of small copy number variations incidentally detected via a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy platform","authors":"","doi":"10.1016/j.fertnstert.2024.07.008","DOIUrl":"10.1016/j.fertnstert.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) platform.</div></div><div><h3>Design</h3><div>Retrospective observational study performed between 2020 and 2022.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>A total of 12,157 patients who underwent clinical PGT-A performed by targeted next-generation sequencing for whole chromosome and large segmental aneuploidies.</div></div><div><h3>Intervention(s)</h3><div>An incidental finding was reported when a CNV gain/loss of at least 3 consecutive amplicons appeared in at least 2 embryos from the same in vitro fertilization cycle.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary outcome measures were the specificity, incidence, inheritance, and pathogenicity of small CNVs detected by the PGT-A platform. Accuracy of the PGT-A platform CNV calls was assessed via concordance with the CNV calls (size and genomic location) on chromosomal microarray of the gamete provider(s). Parental origin of the CNV and pathogenicity classifications were also reported.</div></div><div><h3>Result(s)</h3><div>An incidental finding that met reporting criteria was identified in 75 (0.62%; 95% confidence interval, 0.5%–0.8%) of 12,157 unique PGT-A patients. Chromosomal microarray follow-up was requested for all cases, and results were received for 1 or both members of 65 reproductive couples. In all cases, 1 of the gamete providers was confirmed to have the CNV identified in the embryos (100.0%, N = 65/65; 95% confidence interval, 94.5–100). The identified CNV was of maternal origin in 34 cases (52.3%) and of paternal origin in 31 cases (47.7%). A significant correlation was identified between PGT-A–predicted CNV sizes and chromosomal microarray detected sizes (r = 0.81) and genomic coordinates on parental deoxyribonucleic acid. Twenty-six (40%) of the CNVs were classified as benign/likely benign, 30 (46.2%) as a variant of uncertain significance, and 9 (13.8%) as pathogenic/likely pathogenic.</div></div><div><h3>Conclusion(s)</h3><div>Certain PGT-A platforms may enable the detection of inherited, small CNVs with extremely high specificity without prior knowledge of parental status. Most CNVs in this data set were confirmed to be benign/likely benign or a variant of uncertain significance. Pathogenic/likely pathogenic CNVs associated with a broad range of phenotypic features may also be detected, although a reliable negative predictive value for small CNVs with current PGT-A technologies is unknown because of the many technical challenges.</div></div><div><div>Confirmación y patogenicidad de pequeñas variaciones en el número de copias detectadas incidentalmente mediante una plataforma de pruebas genéticas preimplantacionales para aneuploidía basada en secuenciación de próxima generaci","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.10.002
Eric A Widra
{"title":"Donor incentives revisited.","authors":"Eric A Widra","doi":"10.1016/j.fertnstert.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.10.002","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.07.022
Shichao Cui Ph.D., Li Li M.D., Xingming Zhong Ph.D.
{"title":"A commentary on: “Association of serum uric acid with women’s ovarian reserve: observational study and Mendelian randomization analyses”","authors":"Shichao Cui Ph.D., Li Li M.D., Xingming Zhong Ph.D.","doi":"10.1016/j.fertnstert.2024.07.022","DOIUrl":"10.1016/j.fertnstert.2024.07.022","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.04.035
{"title":"When should assisted reproductive technology workups be performed: following a tiered approach or all on day 1?","authors":"","doi":"10.1016/j.fertnstert.2024.04.035","DOIUrl":"10.1016/j.fertnstert.2024.04.035","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.fertnstert.2024.07.016
Qiaosong Han M.D. , Jinwei Hou M.D. , Zhengao Sun M.D., Ph.D.
{"title":"Seminal plasma exposure in in vitro fertilization cycles: “Dripping water hollows out stone, not through force but through persistence”","authors":"Qiaosong Han M.D. , Jinwei Hou M.D. , Zhengao Sun M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.07.016","DOIUrl":"10.1016/j.fertnstert.2024.07.016","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}