首页 > 最新文献

Fertility and sterility最新文献

英文 中文
Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates 体外受精夫妇的维生素 D 水平:与胚胎质量或妊娠率无关
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.06.023
<div><h3>Objective</h3><div>To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.</div></div><div><h3>Design</h3><div>A retrospective cohort study.</div></div><div><h3>Setting</h3><div>A private human reproduction center.</div></div><div><h3>Patient(s)</h3><div>A total of 267 couples underwent intracytoplasmic sperm injections between January 2017 and March 2019.</div></div><div><h3>Intervention(s)</h3><div>The couples were categorized into four groups on the basis of 25-hydroxy VD (25OHD) levels measured at the beginning of the stimulation protocol: group 1 with 25OHD levels <strong>≥</strong>30 ng/mL for both women and men; group 2 with 25OHD levels <30 ng/mL for both; group 3 women with 25OHD levels <30 ng/mL and men with 25OHD levels ≥30 ng/mL; and group 4 with women with 25OHD level <strong>≥</strong>30 ng/mL and men with 25OHD level <30 ng/mL.</div></div><div><h3>Main Outcome Measure(s)</h3><div>We consider the quantity and quality of embryos during the cleavage as well as blastocyst stages as primary outcomes. Correspondingly, the clinical pregnancy rate (CPR) was regarded as a secondary outcome.</div></div><div><h3>Result(s)</h3><div>Our findings revealed no significant correlations between the studied VD groups and the evaluated outcomes. This includes the quantity and quality of embryos during the cleavage and blastocyst stages, as well as the CPR. Primary analysis revealed a small but statistically significant difference in the duration of controlled ovarian stimulation between group 1 and group 2 (95% confidence interval, 0.07–3.04) and between group 1 and group 3 (95% confidence interval, 0.05–3.23).</div></div><div><h3>Conclusion(s)</h3><div>The present study found no correlation between the studied VD levels and the quantity as well as quality of cleavage or blastocyst stage embryos, nor did it show any impact on CPRs. Further well-designed, prospective studies are warranted to determine whether and how vitamin D affects reproductive outcomes.</div></div><div><div>Niveles de vitamina D en parejas sometidas a tratamiento de fecundación in vitro: falta de asociación con la calidad del embrión o las tasas de embarazo</div></div><div><h3>Objetivo</h3><div>Investigar el impacto potencial de los niveles séricos de vitamina D (VD) en parejas que se someten a un tratamiento de fertilización in vitro en términos de calidad embrionaria y tasas de embarazo.</div></div><div><h3>Diseño</h3><div>Estudio de cohorte retrospectivo.</div></div><div><h3>Lugar</h3><div>Centro privado de reproducción humana.</div></div><div><h3>Paciente(s)</h3><div>Un total de 267 parejas se sometieron a inyecciones intracitoplasmáticas de espermatozoides entre enero de 2017 y marzo de 2019.</div></div><div><h3>Intervención(es)</h3><div>Las parejas se clasificaron en cuatro grupos en función de los niveles de 25-hidroxi VD (25OHD) medidos al i
目的:研究维生素 D 血清水平对试管受精夫妇胚胎质量和妊娠率的潜在影响:调查维生素 D 血清水平对试管受精夫妇胚胎质量和妊娠率的潜在影响:设计:回顾性队列研究:受试者:2017年1月至2019年3月期间接受卵胞浆内单精子注射的267对夫妇。暴露:根据刺激方案开始时测量的25OH维生素D水平,将夫妇分为四组:第1组,男女双方水平均≥30纳克/毫升;第2组,男女双方水平均<30纳克/毫升;第3组,女性<30纳克/毫升,男性≥30纳克/毫升;第4组,女性≥30纳克/毫升,男性<30纳克/毫升.主要结果测量:我们将分裂期和囊胚期胚胎的数量和质量作为主要结果。相应地,临床妊娠率被视为次要结果:结果:我们的研究结果表明,所研究的 VD 组与评估结果之间没有明显的相关性。结果:我们的研究结果表明,所研究的 VD 组与评估结果之间没有明显的相关性,包括胚胎在分裂期和囊胚期的数量和质量,以及临床妊娠率。初步分析显示,第 1 组和第 2 组(P=0.035;CI=0.07 - 3.04)以及第 1 组和第 3 组(P=0.040;CI=0.05 - 3.23)之间的控制性卵巢刺激持续时间差异较小,但具有统计学意义:本研究发现,所研究的 VD 水平与卵裂期或囊胚期胚胎的数量和质量之间没有相关性,对临床妊娠率也没有任何影响。有必要进一步开展精心设计的前瞻性研究,以确定维生素 D 是否以及如何影响生殖结果。
{"title":"Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates","authors":"","doi":"10.1016/j.fertnstert.2024.06.023","DOIUrl":"10.1016/j.fertnstert.2024.06.023","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;A retrospective cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting&lt;/h3&gt;&lt;div&gt;A private human reproduction center.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patient(s)&lt;/h3&gt;&lt;div&gt;A total of 267 couples underwent intracytoplasmic sperm injections between January 2017 and March 2019.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervention(s)&lt;/h3&gt;&lt;div&gt;The couples were categorized into four groups on the basis of 25-hydroxy VD (25OHD) levels measured at the beginning of the stimulation protocol: group 1 with 25OHD levels &lt;strong&gt;≥&lt;/strong&gt;30 ng/mL for both women and men; group 2 with 25OHD levels &lt;30 ng/mL for both; group 3 women with 25OHD levels &lt;30 ng/mL and men with 25OHD levels ≥30 ng/mL; and group 4 with women with 25OHD level &lt;strong&gt;≥&lt;/strong&gt;30 ng/mL and men with 25OHD level &lt;30 ng/mL.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measure(s)&lt;/h3&gt;&lt;div&gt;We consider the quantity and quality of embryos during the cleavage as well as blastocyst stages as primary outcomes. Correspondingly, the clinical pregnancy rate (CPR) was regarded as a secondary outcome.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result(s)&lt;/h3&gt;&lt;div&gt;Our findings revealed no significant correlations between the studied VD groups and the evaluated outcomes. This includes the quantity and quality of embryos during the cleavage and blastocyst stages, as well as the CPR. Primary analysis revealed a small but statistically significant difference in the duration of controlled ovarian stimulation between group 1 and group 2 (95% confidence interval, 0.07–3.04) and between group 1 and group 3 (95% confidence interval, 0.05–3.23).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion(s)&lt;/h3&gt;&lt;div&gt;The present study found no correlation between the studied VD levels and the quantity as well as quality of cleavage or blastocyst stage embryos, nor did it show any impact on CPRs. Further well-designed, prospective studies are warranted to determine whether and how vitamin D affects reproductive outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Niveles de vitamina D en parejas sometidas a tratamiento de fecundación in vitro: falta de asociación con la calidad del embrión o las tasas de embarazo&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Investigar el impacto potencial de los niveles séricos de vitamina D (VD) en parejas que se someten a un tratamiento de fertilización in vitro en términos de calidad embrionaria y tasas de embarazo.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Estudio de cohorte retrospectivo.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Lugar&lt;/h3&gt;&lt;div&gt;Centro privado de reproducción humana.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Paciente(s)&lt;/h3&gt;&lt;div&gt;Un total de 267 parejas se sometieron a inyecciones intracitoplasmáticas de espermatozoides entre enero de 2017 y marzo de 2019.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervención(es)&lt;/h3&gt;&lt;div&gt;Las parejas se clasificaron en cuatro grupos en función de los niveles de 25-hidroxi VD (25OHD) medidos al i","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamete and embryo donation guidance 配子和胚胎捐赠指南。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.06.004
This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors, as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. This revised document incorporates recent information from the US Centers for Disease Control and Prevention, the US Food and Drug Administration, and the American Association of Tissue Banks, with which all programs offering gamete and embryo donation services must be thoroughly familiar, and replaces the document titled ”Recommendations for gamete and embryo donation: a committee opinion,” last published in 2013.
Guía para la donación de gametos y embriones
Este documento proporciona las recomendaciones más recientes para el estudio de candidatos a donación de semen, de ovocitos y de embriones, así como de sus receptores, incorporando información actualizada sobre el cribado y las pruebas óptimas para enfermedades de transmisión sexual, genéticas y evaluaciones psicológicas. Este documento revisado incluye información reciente de los Centros para el Control y la Prevención de Enfermedades de EE. UU., la Administración de Alimentos y Medicamentos de EE. UU. y la Asociación Americana de Bancos de Tejidos, con la cual todos los programas que ofrezcan servicios de donación de gametos y embriones deben estar completamente familiarizados. Este documento reemplaza al titulado "Recomendaciones para la donación de gametos y embriones: una opinión del comité", publicado por última vez en 2013.
本文件提供了对潜在精子、卵细胞和胚胎捐献者及其受捐者进行评估的最新建议,纳入了有关性传播感染、遗传疾病和心理评估的最佳筛查和检测的最新信息。这份修订版文件纳入了美国疾病控制与预防中心、美国食品和药物管理局以及美国组织库协会(American Association of Tissue Banks)提供的最新信息,所有提供配子和胚胎捐献服务的项目都必须充分熟悉这些信息,并取代了 2013 年发布的《配子和胚胎捐献建议:委员会意见》。
{"title":"Gamete and embryo donation guidance","authors":"","doi":"10.1016/j.fertnstert.2024.06.004","DOIUrl":"10.1016/j.fertnstert.2024.06.004","url":null,"abstract":"<div><div>This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors, as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. This revised document incorporates recent information from the US Centers for Disease Control and Prevention, the US Food and Drug Administration, and the American Association of Tissue Banks, with which all programs offering gamete<span> and embryo donation services must be thoroughly familiar, and replaces the document titled ”Recommendations for gamete and embryo donation: a committee opinion,” last published in 2013.</span></div></div><div><div>Guía para la donación de gametos y embriones</div><div>Este documento proporciona las recomendaciones más recientes para el estudio de candidatos a donación de semen, de ovocitos y de embriones, así como de sus receptores, incorporando información actualizada sobre el cribado y las pruebas óptimas para enfermedades de transmisión sexual, genéticas y evaluaciones psicológicas. Este documento revisado incluye información reciente de los Centros para el Control y la Prevención de Enfermedades de EE. UU., la Administración de Alimentos y Medicamentos de EE. UU. y la Asociación Americana de Bancos de Tejidos, con la cual todos los programas que ofrezcan servicios de donación de gametos y embriones deben estar completamente familiarizados. Este documento reemplaza al titulado \"Recomendaciones para la donación de gametos y embriones: una opinión del comité\", publicado por última vez en 2013.</div></div>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative transvaginal ultrasound to standardize bowel endometriosis shaving 术中经阴道超声波检查,规范肠道子宫内膜异位症刮片。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.07.496
Milena Sophie Alec , Jonas Jean Mathieu Vibert , Fabian Grass M.D. , Nicola Pluchino M.D., Ph.D
<div><h3>Objective</h3><div>To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving.</div></div><div><h3>Design</h3><div>Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule.</div></div><div><h3>Setting</h3><div>Lausanne University Hospital and Geneva University Hospital.</div></div><div><h3>Patient(s)</h3><div>Two women with symptomatic endometriosis rectal lesion.</div></div><div><h3>Intervention(s)</h3><div>Preoperative transvaginal ultrasound was performed to measure the rectal nodule. After completing bowel shaving, the surgeon conducted both clinical and sonographic evaluations of the rectal wall. Clinically, this was performed using laparoscopic grasping forceps and sonographically with a transvaginal probe after filling the pelvis with saline solution.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Assessment of the rectal wall for residual disease after bowel shaving and evaluation of the necessity for additional bowel resection.</div></div><div><h3>Result(s)</h3><div>After sonographic evaluation of the rectal wall, the surgeon decided in both patients to perform a discoid resection because of the presence of a residual rectal disease despite thorough bowel shaving.</div></div><div><h3>Conclusion(s)</h3><div>Intraoperative transvaginal ultrasound after bowel endometriosis shaving is a promising technique that is safe, reproducible, and efficient. It aids surgeons in accurately assessing the extent of excision of deep rectosigmoid infiltrating endometriosis and determining the necessity of additional bowel resection to reduce recurrence risk. Moreover, intraoperative ultrasound provides precise measurements of residual nodules, enabling differentiation between persistent, recurrent, or new lesions during follow-up.</div></div><div><div>Uso del Ultrasonido transvaginal intraoperatorio para estandarizar la resección de la endometriosis intestinal</div></div><div><h3>Objetivo</h3><div>Estudiar el uso del ultrasonido transvaginal intraoperatorio después de la resección de la endometriosis intestinal.</div></div><div><h3>Diseño</h3><div>Demostración paso a paso con un video narrado del uso preoperatorio e intraoperatorio del ultrasonido transvaginal en la evaluación de la extensión de un nódulo rectal endometriósico.</div></div><div><h3>Lugar</h3><div>Hospital Universitario de Lausana y Hospital Universitario de Ginebra.</div></div><div><h3>Paciente(s)</h3><div>Dos pacientes con endometriosis intomática rectal.</div></div><div><h3>Intervención(es)</h3><div>Se realizó ecografía transvaginal preoperatoria para medir el nódulo rectal. Después de completar la resección intestinal, el cirujano realizó evaluaciones clínicas y ecográficas de la pared rectal. Clínicamente, esto se realizó usando fórceps de agarre laparoscópico y ecográficamente con una sonda transvaginal después de llenar la pelvis con soluc
目的研究肠道子宫内膜异位症刮除术后术中经阴道超声波的应用:设计:通过播放术前和术中超声的解说视频,逐步演示如何评估子宫内膜异位症直肠结节的范围:洛桑大学医院和日内瓦大学医院:干预措施:术前经阴道超声检查:术前进行经阴道超声波检查,测量直肠结节。在完成肠道剃除后,外科医生对直肠壁进行了临床和超声评估。临床评估使用腹腔镜抓钳进行,声像图评估则在向盆腔注入生理盐水后使用经阴道探头进行:主要结果测量指标:评估肠道剃除后直肠壁是否有残留病变,并评估是否有必要进行额外的肠道切除:在对直肠壁进行超声评估后,外科医生决定对两名患者实施盘状切除术,因为尽管彻底切除了肠道,但仍存在直肠残留疾病:结论:子宫内膜异位症切除术后的术中经阴道超声检查是一项很有前景的技术,它安全、可重复、高效。它有助于外科医生准确评估直肠乙状结肠深部浸润性子宫内膜异位症的切除范围,并确定是否有必要进行额外的肠道切除以降低复发风险。此外,术中超声还能对残留结节进行精确测量,以便在随访过程中区分是持续性病变、复发性病变还是新病变。
{"title":"Intraoperative transvaginal ultrasound to standardize bowel endometriosis shaving","authors":"Milena Sophie Alec ,&nbsp;Jonas Jean Mathieu Vibert ,&nbsp;Fabian Grass M.D. ,&nbsp;Nicola Pluchino M.D., Ph.D","doi":"10.1016/j.fertnstert.2024.07.496","DOIUrl":"10.1016/j.fertnstert.2024.07.496","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting&lt;/h3&gt;&lt;div&gt;Lausanne University Hospital and Geneva University Hospital.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patient(s)&lt;/h3&gt;&lt;div&gt;Two women with symptomatic endometriosis rectal lesion.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervention(s)&lt;/h3&gt;&lt;div&gt;Preoperative transvaginal ultrasound was performed to measure the rectal nodule. After completing bowel shaving, the surgeon conducted both clinical and sonographic evaluations of the rectal wall. Clinically, this was performed using laparoscopic grasping forceps and sonographically with a transvaginal probe after filling the pelvis with saline solution.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measure(s)&lt;/h3&gt;&lt;div&gt;Assessment of the rectal wall for residual disease after bowel shaving and evaluation of the necessity for additional bowel resection.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result(s)&lt;/h3&gt;&lt;div&gt;After sonographic evaluation of the rectal wall, the surgeon decided in both patients to perform a discoid resection because of the presence of a residual rectal disease despite thorough bowel shaving.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion(s)&lt;/h3&gt;&lt;div&gt;Intraoperative transvaginal ultrasound after bowel endometriosis shaving is a promising technique that is safe, reproducible, and efficient. It aids surgeons in accurately assessing the extent of excision of deep rectosigmoid infiltrating endometriosis and determining the necessity of additional bowel resection to reduce recurrence risk. Moreover, intraoperative ultrasound provides precise measurements of residual nodules, enabling differentiation between persistent, recurrent, or new lesions during follow-up.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Uso del Ultrasonido transvaginal intraoperatorio para estandarizar la resección de la endometriosis intestinal&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Estudiar el uso del ultrasonido transvaginal intraoperatorio después de la resección de la endometriosis intestinal.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Demostración paso a paso con un video narrado del uso preoperatorio e intraoperatorio del ultrasonido transvaginal en la evaluación de la extensión de un nódulo rectal endometriósico.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Lugar&lt;/h3&gt;&lt;div&gt;Hospital Universitario de Lausana y Hospital Universitario de Ginebra.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Paciente(s)&lt;/h3&gt;&lt;div&gt;Dos pacientes con endometriosis intomática rectal.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervención(es)&lt;/h3&gt;&lt;div&gt;Se realizó ecografía transvaginal preoperatoria para medir el nódulo rectal. Después de completar la resección intestinal, el cirujano realizó evaluaciones clínicas y ecográficas de la pared rectal. Clínicamente, esto se realizó usando fórceps de agarre laparoscópico y ecográficamente con una sonda transvaginal después de llenar la pelvis con soluc","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oocyte cryopreservation: setting appropriate “eggs-pectations” 卵母细胞冷冻:设定适当的 "卵子预期"。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.08.336
Daniela Diego M.D., Heather S. Hipp M.D.
{"title":"Oocyte cryopreservation: setting appropriate “eggs-pectations”","authors":"Daniela Diego M.D.,&nbsp;Heather S. Hipp M.D.","doi":"10.1016/j.fertnstert.2024.08.336","DOIUrl":"10.1016/j.fertnstert.2024.08.336","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A survey study evaluating donor gamete utilization rates, patient satisfaction, and fertility treatment outcomes according to desired race and ethnicity 一项调查研究,根据所希望的种族和民族,对捐献配子的使用率、患者满意度和生育治疗效果进行评估。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.06.017
<div><h3>Objective</h3><div>To evaluate donor gamete utilization, patient satisfaction, and fertility treatment outcomes of patients pursuing treatment with donor gametes stratified by the desired race as well as ethnicity of the gamete donor.</div></div><div><h3>Design</h3><div>Survey study.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>Patients planning to undergo treatment using donor sperm and/or donor oocytes at a single academic fertility clinic in the Southeastern United States between 2015 and 2020.</div></div><div><h3>Intervention(s)</h3><div>None.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Utilization rates of donor gametes, satisfaction with donor gamete selection, and fertility treatment outcomes stratified by race and ethnicity of patient, as well as that of their gamete donor.</div></div><div><h3>Result(s)</h3><div>Four hundred fifty patients were eligible for inclusion and 170 (38%) responded to the survey. Among the respondents, 59% desired a non-Hispanic White gamete donor and 20% desired a non-Hispanic Black gamete donor. Patients seeking a non-Hispanic Black gamete donor had lower odds of using donor gametes (Odds ratio [OR], 0.13; 95% confidence interval [CI], 0.04–0.40) compared with individuals seeking a non-Hispanic White gamete donor. When evaluating satisfaction with donor gamete selection, patients seeking a non-Hispanic Black gamete donor reported lower satisfaction compared with individuals seeking a non-Hispanic White gamete donor (OR, 0.19; 95% CI, 0.09–0.43). When evaluating fertility outcomes, Non-Hispanic Black patients and those using non-Hispaninc Black gamete donors were found to have lower odds of successful conception compared with non-Hispanic White patients (OR, 0.18; 95% CI, 0.07–0.46) and individuals seeking non-Hispanic White gamete donors (OR, 0.26; 95% CI, 0.09–0.75), respectively.</div></div><div><h3>Conclusion(s)</h3><div>Patients seeking non-Hispanic Black donor gametes have lower utilization rates, less satisfaction with gamete donor selection, and lower odds of conception when compared with those seeking non-Hispanic White gamete donors. These findings highlight the need for more racial diversity within donor gamete banks, as well as within the donor pools available through agencies and fertility clinics.</div></div><div><div>Un estudio de encuesta evaluando tasas de utilización de gametos donados, satisfacción del paciente, y resultados de tratamientos de fertilidad de acuerdo a la raza y etnicidad deseada</div></div><div><h3>Objetivo</h3><div>Evaluar la utilización de los gametos donados, satisfacción del paciente, y los resultados de pacientes que siguen un tratamiento con donantes de gametos estratificados por la raza deseada así como la etnicidad del donante de gametos.</div></div><div><h3>Diseño</h3><div>Estudio de encuesta.</div></div><div><h3>Lugar</h3><div>Clínica.</div></div><div><h3>Paciente (s)</h3><div>Pacientes planeando seguir un trat
目的根据配子捐献者所希望的种族和民族,评估使用配子捐献者治疗的患者的配子捐献情况、患者满意度和生育治疗结果:调查研究 对象:2015年至2020年期间,计划在美国东南部一家学术性生殖诊所接受捐献精子和/或捐献卵细胞治疗的患者:按患者及其配子捐献者的种族和民族划分的捐献配子使用率、对捐献配子选择的满意度和生育治疗结果:共有 450 名患者符合调查条件,其中 170 人(38%)接受了调查。其中,59%的受访者希望获得非西班牙裔白人配子捐献者,20%希望获得非西班牙裔黑人配子捐献者。与寻求非西班牙裔白人配子捐献者相比,寻求非西班牙裔黑人配子捐献者的患者使用配子捐献者的几率较低(OR = 0.13,95% CI 0.04 - 0.40)。在评估配子捐献者选择满意度时,与寻求非西班牙裔白人配子捐献者的患者相比,寻求非西班牙裔黑人配子捐献者的患者满意度较低(OR 0.19,95% CI [0.09-0.43])。在评估生育结果时发现,与非西班牙裔白人患者(OR=0.18,95% CI 0.07-0.46)和寻求非西班牙裔白人配子捐献者(OR=0.26,95% CI 0.09-0.75)相比,非西班牙裔黑人患者和利用非西班牙裔黑人配子捐献者成功受孕的几率较低:结论:与寻求非西班牙裔白人配子捐献者相比,寻求非西班牙裔黑人配子捐献者的患者利用率较低,对配子捐献者选择的满意度较低,受孕几率也较低。这些研究结果突出表明,配子捐献者库以及机构和生育诊所提供的捐献者库中需要更多的种族多样性。
{"title":"A survey study evaluating donor gamete utilization rates, patient satisfaction, and fertility treatment outcomes according to desired race and ethnicity","authors":"","doi":"10.1016/j.fertnstert.2024.06.017","DOIUrl":"10.1016/j.fertnstert.2024.06.017","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate donor gamete utilization, patient satisfaction, and fertility treatment outcomes of patients pursuing treatment with donor gametes stratified by the desired race as well as ethnicity of the gamete donor.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Survey study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting&lt;/h3&gt;&lt;div&gt;Clinic.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patient(s)&lt;/h3&gt;&lt;div&gt;Patients planning to undergo treatment using donor sperm and/or donor oocytes at a single academic fertility clinic in the Southeastern United States between 2015 and 2020.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervention(s)&lt;/h3&gt;&lt;div&gt;None.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measure(s)&lt;/h3&gt;&lt;div&gt;Utilization rates of donor gametes, satisfaction with donor gamete selection, and fertility treatment outcomes stratified by race and ethnicity of patient, as well as that of their gamete donor.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result(s)&lt;/h3&gt;&lt;div&gt;Four hundred fifty patients were eligible for inclusion and 170 (38%) responded to the survey. Among the respondents, 59% desired a non-Hispanic White gamete donor and 20% desired a non-Hispanic Black gamete donor. Patients seeking a non-Hispanic Black gamete donor had lower odds of using donor gametes (Odds ratio [OR], 0.13; 95% confidence interval [CI], 0.04–0.40) compared with individuals seeking a non-Hispanic White gamete donor. When evaluating satisfaction with donor gamete selection, patients seeking a non-Hispanic Black gamete donor reported lower satisfaction compared with individuals seeking a non-Hispanic White gamete donor (OR, 0.19; 95% CI, 0.09–0.43). When evaluating fertility outcomes, Non-Hispanic Black patients and those using non-Hispaninc Black gamete donors were found to have lower odds of successful conception compared with non-Hispanic White patients (OR, 0.18; 95% CI, 0.07–0.46) and individuals seeking non-Hispanic White gamete donors (OR, 0.26; 95% CI, 0.09–0.75), respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion(s)&lt;/h3&gt;&lt;div&gt;Patients seeking non-Hispanic Black donor gametes have lower utilization rates, less satisfaction with gamete donor selection, and lower odds of conception when compared with those seeking non-Hispanic White gamete donors. These findings highlight the need for more racial diversity within donor gamete banks, as well as within the donor pools available through agencies and fertility clinics.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Un estudio de encuesta evaluando tasas de utilización de gametos donados, satisfacción del paciente, y resultados de tratamientos de fertilidad de acuerdo a la raza y etnicidad deseada&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Evaluar la utilización de los gametos donados, satisfacción del paciente, y los resultados de pacientes que siguen un tratamiento con donantes de gametos estratificados por la raza deseada así como la etnicidad del donante de gametos.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Estudio de encuesta.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Lugar&lt;/h3&gt;&lt;div&gt;Clínica.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Paciente (s)&lt;/h3&gt;&lt;div&gt;Pacientes planeando seguir un trat","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Confirmation and pathogenicity of small copy number variations incidentally detected via a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy platform 通过基于定向下一代测序的 PGT-A 平台偶然检测到的小拷贝数变异的确认和致病性。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.07.008
<div><h3>Objective</h3><div>To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) platform.</div></div><div><h3>Design</h3><div>Retrospective observational study performed between 2020 and 2022.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>A total of 12,157 patients who underwent clinical PGT-A performed by targeted next-generation sequencing for whole chromosome and large segmental aneuploidies.</div></div><div><h3>Intervention(s)</h3><div>An incidental finding was reported when a CNV gain/loss of at least 3 consecutive amplicons appeared in at least 2 embryos from the same in vitro fertilization cycle.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary outcome measures were the specificity, incidence, inheritance, and pathogenicity of small CNVs detected by the PGT-A platform. Accuracy of the PGT-A platform CNV calls was assessed via concordance with the CNV calls (size and genomic location) on chromosomal microarray of the gamete provider(s). Parental origin of the CNV and pathogenicity classifications were also reported.</div></div><div><h3>Result(s)</h3><div>An incidental finding that met reporting criteria was identified in 75 (0.62%; 95% confidence interval, 0.5%–0.8%) of 12,157 unique PGT-A patients. Chromosomal microarray follow-up was requested for all cases, and results were received for 1 or both members of 65 reproductive couples. In all cases, 1 of the gamete providers was confirmed to have the CNV identified in the embryos (100.0%, N = 65/65; 95% confidence interval, 94.5–100). The identified CNV was of maternal origin in 34 cases (52.3%) and of paternal origin in 31 cases (47.7%). A significant correlation was identified between PGT-A–predicted CNV sizes and chromosomal microarray detected sizes (r = 0.81) and genomic coordinates on parental deoxyribonucleic acid. Twenty-six (40%) of the CNVs were classified as benign/likely benign, 30 (46.2%) as a variant of uncertain significance, and 9 (13.8%) as pathogenic/likely pathogenic.</div></div><div><h3>Conclusion(s)</h3><div>Certain PGT-A platforms may enable the detection of inherited, small CNVs with extremely high specificity without prior knowledge of parental status. Most CNVs in this data set were confirmed to be benign/likely benign or a variant of uncertain significance. Pathogenic/likely pathogenic CNVs associated with a broad range of phenotypic features may also be detected, although a reliable negative predictive value for small CNVs with current PGT-A technologies is unknown because of the many technical challenges.</div></div><div><div>Confirmación y patogenicidad de pequeñas variaciones en el número de copias detectadas incidentalmente mediante una plataforma de pruebas genéticas preimplantacionales para aneuploidía basada en secuenciación de próxima generaci
目的评估基于定向下一代测序(NGS)的PGT-A平台检测到的小拷贝数变异(CNVs)的技术准确性、遗传性和致病性:设计:2020-2022年间进行的回顾性观察研究:12157名患者接受了通过靶向NGS进行的全染色体和大段非整倍体临床PGT-A:如果在同一试管婴儿周期的至少两个胚胎中出现至少三个连续扩增子的CNV增益/缺失,即为偶然发现:主要结果指标:PGT-A 平台检测到的小 CNV 的特异性、发生率、遗传性和致病性。通过与配子提供者染色体芯片上的 CNV 调用(大小和基因组位置)的一致性来评估 PGT-A 平台 CNV 调用的准确性。此外,还报告了 CNV 的亲本来源和致病性分类:在 12,157 例 PGT-A 患者中,有 75 例(0.62%;95%CI:0.5-0.8%)患者的偶然发现符合报告标准。我们要求对所有病例进行染色体微阵列随访,并收到了 65 对生育夫妇中一方或双方的结果。在所有病例中,配子提供者之一被证实在胚胎中发现了 CNV(100.0%:N=65/65 95%CI:94.5-100)。已确定的 CNV 有 34 例(52.3%)来自母体,31 例(47.7%)来自父方。PGT-A 预测的 CNV 大小与染色体微阵列检测到的大小(r=0.81)和亲代 DNA 上的基因组坐标之间存在明显的相关性。26个CNV(40%)被归类为良性/可能良性,30个(46.2%)被归类为意义不确定的变异(VUS),9个(13.8%)被归类为致病性/可能致病性:结论:某些 PGT-A 平台可以在不事先了解父母状况的情况下,以极高的特异性检测遗传性小 CNV。该数据集中的大多数 CNV 被证实为良性/可能良性或 VUS;然而,也可能检测到与多种表型特征相关的致病性/可能致病性 CNV,但由于存在许多技术难题,目前的 PGT-A 技术对小 CNV 的可靠阴性预测值尚不清楚。
{"title":"Confirmation and pathogenicity of small copy number variations incidentally detected via a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy platform","authors":"","doi":"10.1016/j.fertnstert.2024.07.008","DOIUrl":"10.1016/j.fertnstert.2024.07.008","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) platform.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Retrospective observational study performed between 2020 and 2022.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting&lt;/h3&gt;&lt;div&gt;Clinic.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patient(s)&lt;/h3&gt;&lt;div&gt;A total of 12,157 patients who underwent clinical PGT-A performed by targeted next-generation sequencing for whole chromosome and large segmental aneuploidies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervention(s)&lt;/h3&gt;&lt;div&gt;An incidental finding was reported when a CNV gain/loss of at least 3 consecutive amplicons appeared in at least 2 embryos from the same in vitro fertilization cycle.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measure(s)&lt;/h3&gt;&lt;div&gt;The primary outcome measures were the specificity, incidence, inheritance, and pathogenicity of small CNVs detected by the PGT-A platform. Accuracy of the PGT-A platform CNV calls was assessed via concordance with the CNV calls (size and genomic location) on chromosomal microarray of the gamete provider(s). Parental origin of the CNV and pathogenicity classifications were also reported.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result(s)&lt;/h3&gt;&lt;div&gt;An incidental finding that met reporting criteria was identified in 75 (0.62%; 95% confidence interval, 0.5%–0.8%) of 12,157 unique PGT-A patients. Chromosomal microarray follow-up was requested for all cases, and results were received for 1 or both members of 65 reproductive couples. In all cases, 1 of the gamete providers was confirmed to have the CNV identified in the embryos (100.0%, N = 65/65; 95% confidence interval, 94.5–100). The identified CNV was of maternal origin in 34 cases (52.3%) and of paternal origin in 31 cases (47.7%). A significant correlation was identified between PGT-A–predicted CNV sizes and chromosomal microarray detected sizes (r = 0.81) and genomic coordinates on parental deoxyribonucleic acid. Twenty-six (40%) of the CNVs were classified as benign/likely benign, 30 (46.2%) as a variant of uncertain significance, and 9 (13.8%) as pathogenic/likely pathogenic.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion(s)&lt;/h3&gt;&lt;div&gt;Certain PGT-A platforms may enable the detection of inherited, small CNVs with extremely high specificity without prior knowledge of parental status. Most CNVs in this data set were confirmed to be benign/likely benign or a variant of uncertain significance. Pathogenic/likely pathogenic CNVs associated with a broad range of phenotypic features may also be detected, although a reliable negative predictive value for small CNVs with current PGT-A technologies is unknown because of the many technical challenges.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Confirmación y patogenicidad de pequeñas variaciones en el número de copias detectadas incidentalmente mediante una plataforma de pruebas genéticas preimplantacionales para aneuploidía basada en secuenciación de próxima generaci","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Donor incentives revisited. 重新审视捐助方的激励措施。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.10.002
Eric A Widra
{"title":"Donor incentives revisited.","authors":"Eric A Widra","doi":"10.1016/j.fertnstert.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.10.002","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A commentary on: “Association of serum uric acid with women’s ovarian reserve: observational study and Mendelian randomization analyses” 一篇评论:血清尿酸与女性卵巢储备功能的关系:观察研究与孟德尔随机分析》的评论。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.07.022
Shichao Cui Ph.D., Li Li M.D., Xingming Zhong Ph.D.
{"title":"A commentary on: “Association of serum uric acid with women’s ovarian reserve: observational study and Mendelian randomization analyses”","authors":"Shichao Cui Ph.D.,&nbsp;Li Li M.D.,&nbsp;Xingming Zhong Ph.D.","doi":"10.1016/j.fertnstert.2024.07.022","DOIUrl":"10.1016/j.fertnstert.2024.07.022","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When should assisted reproductive technology workups be performed: following a tiered approach or all on day 1? 应何时进行 ART 检查?是采用分层方法,还是全部在第一天进行?
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.04.035
{"title":"When should assisted reproductive technology workups be performed: following a tiered approach or all on day 1?","authors":"","doi":"10.1016/j.fertnstert.2024.04.035","DOIUrl":"10.1016/j.fertnstert.2024.04.035","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seminal plasma exposure in in vitro fertilization cycles: “Dripping water hollows out stone, not through force but through persistence” 试管婴儿周期中的精浆暴露:"滴水穿石,非力而为"。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.fertnstert.2024.07.016
Qiaosong Han M.D. , Jinwei Hou M.D. , Zhengao Sun M.D., Ph.D.
{"title":"Seminal plasma exposure in in vitro fertilization cycles: “Dripping water hollows out stone, not through force but through persistence”","authors":"Qiaosong Han M.D. ,&nbsp;Jinwei Hou M.D. ,&nbsp;Zhengao Sun M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.07.016","DOIUrl":"10.1016/j.fertnstert.2024.07.016","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Fertility and sterility
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1