Associations between brain structures, cognition and dual-task performance in patients with mild cognitive impairment: A study based on voxel-based morphology

IF 1.6 3区心理学 Q4 NEUROSCIENCES Human Movement Science Pub Date : 2024-08-09 DOI:10.1016/j.humov.2024.103257

Xue Cheng , Xin Huang , Qiuhua Yu , Yiyi Zheng , Jiaxuan Zheng , Shuzhi Zhao , Wai Leung Ambrose Lo , Chuhuai Wang , Siyun Zhang

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Abstract

Background

This study aimed to explore the associations between brain structures, cognition, and motor control in participants with mild cognitive impairment (MCI), with a focus on dual-task performance.

Methods

Thirty MCI patients and thirty healthy controls were enrolled. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Structural magnetic resonance imaging data were analyzed using voxel-based morphometry (VBM) to calculate brain parenchyma volume and gray matter volume (GMV). Participants performed single- and dual-task Timed Up and Go (TUG) tests, and the correlations between significant GMV differences and task execution time was analyzed.

Results

MCI patients showed significantly lower MoCA scores, particularly in visuospatial/executive, attention, and delayed recall domains (p < 0.05). Dual-task TUG execution time was significantly increased in MCI patients (p < 0.05). The GMV in the right anterior lobe of the cerebellum and both insulae was positively correlated with visuospatial/executive scores (FDR-corrected, p < 0.05). The GMV of the right cerebellar anterior lobe and insula were significantly reduced in MCI patients (p < 0.05). The GMV of the right cerebellar anterior lobe was negatively correlated with dual-task execution time (r = −0.32, p = 0.012).

Conclusion

Smaller GMV in the right anterior lobe of the cerebellum was associated with impaired dual-task performance, which may provide more evidence for the neural mechanisms of cognitive and motor function impairments in MCI.

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轻度认知障碍患者的大脑结构、认知能力和双任务表现之间的关联：基于体素形态学的研究。

研究背景本研究旨在探讨轻度认知障碍（MCI）患者的大脑结构、认知能力和运动控制能力之间的关联，重点是双任务表现：方法：研究人员招募了 30 名 MCI 患者和 30 名健康对照者。认知功能通过蒙特利尔认知评估（MoCA）进行评估。结构磁共振成像数据采用体素形态计量法（VBM）进行分析，以计算脑实质体积和灰质体积（GMV）。受试者进行了单任务和双任务的定时爬行（TUG）测试，并分析了显著的 GMV 差异与任务执行时间之间的相关性：结果发现：MCI 患者的 MoCA 得分明显较低，尤其是在视觉空间/执行、注意力和延迟回忆领域（p 结论：MCI 患者的右前臂 GMV 较小，而左前臂 GMV 较大（p 结论：MCI 患者的右前臂 GMV 较小）：小脑右前叶较小的GMV与双任务表现受损有关，这可能为MCI患者认知和运动功能受损的神经机制提供了更多证据。

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来源期刊

Human Movement Science 医学-神经科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

42 days

期刊介绍： Human Movement Science provides a medium for publishing disciplinary and multidisciplinary studies on human movement. It brings together psychological, biomechanical and neurophysiological research on the control, organization and learning of human movement, including the perceptual support of movement. The overarching goal of the journal is to publish articles that help advance theoretical understanding of the control and organization of human movement, as well as changes therein as a function of development, learning and rehabilitation. The nature of the research reported may vary from fundamental theoretical or empirical studies to more applied studies in the fields of, for example, sport, dance and rehabilitation with the proviso that all studies have a distinct theoretical bearing. Also, reviews and meta-studies advancing the understanding of human movement are welcome. These aims and scope imply that purely descriptive studies are not acceptable, while methodological articles are only acceptable if the methodology in question opens up new vistas in understanding the control and organization of human movement. The same holds for articles on exercise physiology, which in general are not supported, unless they speak to the control and organization of human movement. In general, it is required that the theoretical message of articles published in Human Movement Science is, to a certain extent, innovative and not dismissible as just "more of the same."