The effects of moderate prenatal alcohol exposure on performance in hippocampal-sensitive spatial memory and anxiety tasks by adult male and female rat offspring

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Alcohol Pub Date : 2024-08-08 DOI:10.1016/j.alcohol.2024.08.002
Gabriela Acosta , Kehiry Trejo Rico , John T. Madden , Ariyana LaCour , Enhui Wang , Lilliana M. Sanchez , Suzy Davies , Carlos Maestas-Olguin , Kayla B. Cox , Nicole C. Reyna , Jeremy Hogeveen , Daniel D. Savage , Nathan S. Pentkowski , Benjamin J. Clark
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Abstract

Moderate prenatal alcohol exposure (mPAE) results in structural alterations to the hippocampus. Previous studies have reported impairments in hippocampal-sensitive tasks, but have not compared performance between male and female animals. In the present study, performance in hippocampal-sensitive spatial memory and anxiety behavior tests were compared across adult male and female saccharin (SACC) control mPAE Long-Evans rat offspring. Two tests of spatial memory were conducted that were aimed at assessing memory for recently acquired spatial information: A delayed spatial alternation task using an M-shaped maze and a delayed match-to-place task in the Morris water task. In both tasks, rats in SACC and mPAE groups showed similar learning and retention of a spatial location even after a 2-h interval between encoding and retention. A separate group of adult male and female SACC and mPAE rat offspring were tested for anxiety-like behaviors in the elevated plus-maze paradigm. In this test, both male and female mPAE rats exhibited a significantly greater amount of time and a greater number of head dips in the open arms, while locomotion and open arm entries did not differ between groups. The results suggest that mPAE produces a reduction in anxiety-like behaviors in both male and female rats in the elevated plus-maze.

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中度产前酒精暴露对成年雄性和雌性大鼠后代海马敏感空间记忆和焦虑任务表现的影响
中度产前酒精暴露(mPAE)会导致海马结构改变。以前的研究报告了海马敏感任务的损伤,但没有比较雌雄动物的表现。本研究比较了成年雄性和雌性糖精(SACC)对照 mPAE Long-Evans 大鼠后代在海马敏感空间记忆和焦虑行为测试中的表现。进行了两项空间记忆测试,旨在评估对最近获得的空间信息的记忆:一项是使用 M 型迷宫的延迟空间交替任务,另一项是莫里斯水任务中的延迟匹配到位置任务。在这两项任务中,SACC 组和 mPAE 组大鼠对空间位置的学习和保持情况相似,即使编码和保持之间间隔了 2 小时。另外一组成年雄性 SACC 和雌性 mPAE 大鼠后代在高架加迷宫范例中进行了焦虑行为测试。在该测试中,雄性和雌性 mPAE 大鼠在开放臂中表现出的时间和头下垂的次数都显著增加,而运动和进入开放臂的次数在组间没有差异。结果表明,mPAE 可减少雄性和雌性大鼠在高架加迷宫中的焦虑样行为。
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来源期刊
Alcohol
Alcohol 医学-毒理学
CiteScore
4.60
自引率
4.30%
发文量
74
审稿时长
15.6 weeks
期刊介绍: Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.
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