Alcohol最新文献 - Book学术

The role of emotion dysregulation, illness-related depression, and general anxiety in hangover anxiety 情绪失调、疾病相关抑郁和一般性焦虑在宿醉焦虑中的作用。

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2026-01-19 DOI: 10.1016/j.alcohol.2026.01.156

Kristin Tellez-Monnery, Ann M. Weber

Objectives

Anxiety during hangovers, a common yet understudied phenomenon, may be influenced by psychological factors prior to or concurrent with the hangover event. Alcohol intake levels; general anxiety and depression; depression symptoms during acute physical illness; state- and trait-based emotion dysregulation; and repetitive negative thinking (RNT) were examined.

Methods

Participants reporting current alcohol consumption (n = 217) completed baseline assessments of psychological traits. Two-week follow-up (n = 136) captured state-based factors and hangover outcomes. Participants reporting hangovers (n = 39) completed symptom assessments. Anxiety severity was assessed when reporting any anxiety during hangovers, and zero severity assigned otherwise. Non-hangover participants were excluded from analyses. Non-parametric (random forest) and parametric (lasso regression) models that are insensitive to multicollinearity were used to identify psychological factors most strongly associated with hangover anxiety.

Results

State-based emotion dysregulation was the most important explanatory factor in the random forest model, followed by illness-related depression, general anxiety, trait emotion dysregulation, state- and trait-based RNT, and general depression. Baseline and follow-up alcohol intake showed minimal relevance in explaining hangover anxiety severity. Lasso regression also selected state-based emotion dysregulation and general anxiety as relevant explanatory factors.

Conclusions

Variables most strongly associated with hangover anxiety were state-based emotion dysregulation, illness-related depression, and general anxiety. The role of illness-related depression may reflect underlying inflammation or unique psychological mechanisms. State-based emotion dysregulation and inflammation emerged as relevant factors warranting additional study in the context of hangover anxiety intervention development. Additionally, findings underscore the higher probability of hangover anxiety among individuals with elevated general anxiety.

目的：宿醉期间的焦虑是一种常见但尚未得到充分研究的现象，可能受到宿醉事件前心理因素的影响。酒精摄入量；一般性焦虑和抑郁；急性躯体疾病期间的抑郁症状；基于状态和特质的情绪失调；和重复性消极思维（RNT）。方法：报告当前饮酒的参与者（n = 217）完成了心理特征的基线评估。为期两周的随访（n = 136）捕获了基于状态的因素和宿醉结果。报告宿醉的参与者（n = 39）完成了症状评估。当报告任何宿醉期间的焦虑时，评估焦虑严重程度，否则分配零严重程度。非宿醉参与者被排除在分析之外。使用对多重共线性不敏感的非参数（随机森林）和参数（套索回归）模型来确定与宿醉焦虑最密切相关的心理因素。结果：基于状态的情绪失调是随机森林模型中最重要的解释因子，其次是疾病相关抑郁、一般焦虑、特质情绪失调、基于状态和特质的RNT和一般抑郁。基线和随访的酒精摄入量与解释宿醉焦虑严重程度的相关性很小。Lasso回归还选择了基于状态的情绪失调和一般焦虑作为相关的解释因素。结论：与宿醉焦虑最密切相关的变量是基于状态的情绪失调、疾病相关的抑郁和一般性焦虑。疾病相关抑郁的作用可能反映了潜在的炎症或独特的心理机制。在宿醉焦虑干预发展的背景下，基于状态的情绪失调和炎症成为需要进一步研究的相关因素。此外，研究结果强调，在一般焦虑水平较高的个体中，宿醉焦虑的可能性更高。

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引用次数: 0

A single dose of ethanol in adult mice transiently alters the organization of spontaneous exploratory behaviors in a dark open field 给成年小鼠注射单剂量的乙醇，会短暂地改变小鼠在黑暗开阔地带自发探索行为的组织。

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-12-29 DOI: 10.1016/j.alcohol.2025.12.002

Tia N. Donaldson , Ericka A. Schaeffer , Holly Sampson , Bethany Brundage , David Linsenbardt , Douglas G. Wallace , Benjamin J. Clark

Acute exposure to ethanol is known to produce significant alterations to the functions of the hippocampus leading to “blackouts” which are defined as temporary disruptions to the encoding and retention of memories. The hippocampus has a prominent role in generating representations of spatial location and contributes to spatial navigation. In open environments, spatial exploratory behaviors are organized such that animals spontaneously alternate between long duration stops (absence of movement) at a specific home base location and exploratory trips or progressions (locomotion between locations) into the remaining environment. Open field exploratory behaviors are organized even in darkness, suggesting a contribution of self-motion cues (e.g., vestibular) to spatial behavior. In the present study, we tested the hypothesis that acute single-dose ethanol exposure in adult mice would disrupt the expression of organized exploratory behaviors in an open field under darkened conditions. Male and female adult mice received a single injection of ethanol and explored a dark environment (under infrared light) for 30 min. Mice tested immediately after the injection exhibited reductions in locomotion and spontaneous behavior, while those tested 30 min later only exhibited suppressed locomotion. These results suggest that ethanol exposure leads to alterations in spontaneous exploratory behaviors.

众所周知，急性暴露于乙醇中会对海马体的功能产生重大改变，导致“失忆”，这被定义为记忆编码和保留的暂时中断。海马体在产生空间位置表征和空间导航中起着重要作用。在开放环境中，空间探索行为是这样组织的，即动物自发地在特定的基地位置长时间停留（不活动）和探索旅行或进展（在位置之间移动）之间交替进入剩余环境。即使在黑暗中，开放领域的探索行为也是有组织的，这表明自我运动线索（如前庭）对空间行为的贡献。在本研究中，我们验证了一个假设，即成年小鼠急性单剂量乙醇暴露会在黑暗条件下破坏开放区域中有组织的探索行为的表达。雄性和雌性成年小鼠接受单次乙醇注射，并在黑暗环境（红外光下）探索30分钟。注射后立即测试的小鼠表现出运动和自发行为的减少，而30分钟后测试的小鼠仅表现出抑制运动。这些结果表明，乙醇暴露会导致自发探索行为的改变。

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引用次数: 0

Alcohol use and pain: Novel insights and emerging questions 酒精使用和疼痛：新的见解和新出现的问题。

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-12-08 DOI: 10.1016/j.alcohol.2025.12.001

Jeff Boissoneault

引用次数: 0

Imposter syndrome and alcohol use among graduate students: An exploratory study 研究生冒名顶替综合症与酒精使用：一项探索性研究

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-26 DOI: 10.1016/j.alcohol.2025.11.006

Kristina Miljkovic , Wei-Lin Wang , Katherine Vorpe , Thomas Valente , Rose Marie Ward

Objective

Imposter syndrome, characterized by persistent self-doubt and difficulty in internalizing accomplishments, is associated with psychological distress and maladaptive coping. Graduate students may be particularly vulnerable given academic demands and transitional life phases. This study explored whether coping-related drinking motives account for the association between imposter syndrome and alcohol consumption, and whether gender moderates these associations.

Methods

Participants were 1158 graduate students enrolled at a large Midwestern university in 2024. Self-report measures assessed imposter syndrome, coping-related drinking motives, drinking quantity, and drinking frequency. Structural equation modeling tested associations, with drinking quantity and frequency modeled as observed indicators of a latent alcohol consumption construct. Interaction terms and bootstrapped differences in conditional indirect effects tested gender as a moderator.

Results

Imposter syndrome was significantly associated with coping-related drinking motives (β = 1.007, p < 0.001), which was associated with alcohol consumption (β = 16.352, p < 0.001). The indirect path from imposter syndrome to alcohol consumption was significant (p < 0.001), but the direct path was non-significant (p = 0.121). Gender moderated the indirect effect of imposter syndrome on alcohol consumption via coping-related drinking (p < 0.001), with a stronger pathway among women.

Conclusions

Findings reveal a gender-moderated indirect pathway in which coping-related drinking motives connect imposter syndrome and alcohol consumption among graduate students. They also highlight a plausible pathway warranting longitudinal testing to determine whether coping motives function as a mediating mechanism. Results emphasize the importance of addressing high stress and maladaptive coping in graduate training environments, with future interventions promoting cognitive strategies to reframe self-doubt and behavioral strategies that support adaptive coping.

目的冒名顶替者综合征以持续的自我怀疑和难以内化成就为特征，与心理困扰和适应不良有关。考虑到学业要求和生活过渡阶段，研究生可能特别容易受到伤害。这项研究探讨了与应对相关的饮酒动机是否解释了冒名顶替综合症和饮酒之间的联系，以及性别是否调节了这些联系。研究对象为1158名2024年在中西部一所大型大学入学的研究生。自我报告测量评估了冒名顶替综合症、应对相关的饮酒动机、饮酒量和饮酒频率。结构方程模型检验关联，饮酒量和频率建模为潜在酒精消费结构的观察指标。在条件间接效应中，相互作用术语和自举差异测试了性别作为调节因子。结果simposter综合征与应对相关饮酒动机显著相关（β = 1.007, p < 0.001），与饮酒相关（β = 16.352, p < 0.001）。从冒名顶替综合症到饮酒的间接路径显著（p < 0.001），但直接路径不显著（p = 0.121）。性别调节了冒名顶替综合症通过应对相关饮酒对酒精消费的间接影响（p < 0.001），在女性中通路更强。结论：研究结果揭示了一个性别调节的间接途径，即与应对相关的饮酒动机将冒名顶替综合症与研究生的酒精消费联系起来。他们还强调了一个合理的途径，需要纵向测试来确定应对动机是否作为中介机制起作用。研究结果强调了在研究生培训环境中解决高压力和适应不良应对的重要性，未来的干预措施将促进认知策略来重塑自我怀疑和支持适应性应对的行为策略。

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引用次数: 0

Acute ethanol enhances septohippocampal coordination but disrupts intrinsic hippocampal theta dynamics during foraging 急性乙醇增强了中隔海马体的协调，但破坏了觅食过程中海马体的内在动态

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-24 DOI: 10.1016/j.alcohol.2025.11.001

Caleb B. Darden , Meagan D. Marks , Andrew J. Kesner

Theta oscillations – rhythmic patterns of synchronous activity within discrete brain regions – are known to support memory, navigation, and behavioral coordination, and are sensitive to pharmacological manipulation. Acute ethanol (EtOH) exposure has been shown to alter theta oscillations, but its effects on transient theta bursts and cross-regional coordination during naturalistic behavior remain unclear. We recorded local field potentials (LFPs) from the medial septum (MS), hippocampal Cornu Ammonis 1 (CA1), and medial prefrontal cortex (mPFC) in freely foraging mice following intraperitoneal injection of EtOH (1.5 g/kg) or saline. We analyzed spectral power, theta burst dynamics, phase, and lag timing. Burst features from CA1 were used to train a machine learning classifier to predict session condition. EtOH impaired locomotion and reduced goal-directed behaviors, particularly early in the session. In CA1, theta power shifted toward lower frequencies and lagged coherence declined. EtOH increased the frequency but reduced the duration of theta bursts in CA1, and in MS, only burst count increased. EtOH enhanced the temporal alignment of MS–CA1 burst pairs. Phase-locking between CA1 and MS during coupled bursts remained present but showed altered structure. Our classifier achieved robust performance using burst features such as skew and entropy, and reliably distinguished treatment conditions. EtOH modulates septohippocampal dynamics by altering the timing and structure of theta bursts. These results suggest that burst-level features are sensitive markers of EtOH's circuit-level effects during naturalistic behavior.

Theta振荡-在离散的大脑区域内同步活动的节律模式-已知支持记忆，导航和行为协调，并且对药物操作敏感。急性乙醇（EtOH）暴露已被证明可以改变θ波振荡，但其对自然行为中瞬时θ波爆发和跨区域协调的影响尚不清楚。我们记录了自由觅食小鼠腹腔注射EtOH （1.5 g/kg）或生理盐水后，中隔（MS）、海马海马角1 （CA1）和内侧前额叶皮层（mPFC）的局部场电位（LFPs）。我们分析了频谱功率，theta突发动态，相位和滞后时间。使用CA1的突发特征来训练机器学习分类器来预测会话状态。EtOH损害了运动能力，减少了目标导向行为，尤其是在治疗的早期。在CA1中，θ波功率向较低频率偏移，滞后相干性下降。在CA1中，EtOH增加了θ脉冲的频率，但减少了持续时间，而在MS中，只有脉冲计数增加。EtOH增强了MS-CA1突变对的时间比对。在耦合脉冲中，CA1和MS之间的锁相仍然存在，但结构发生了变化。我们的分类器使用诸如倾斜和熵等突发特征实现了鲁棒性能，并可靠地区分了处理条件。EtOH通过改变θ波爆发的时间和结构来调节中隔海马的动力学。这些结果表明突发水平特征是自然行为中EtOH回路水平效应的敏感标志。

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引用次数: 0

The impact of maternal separation stress on the CRFergic system in the extended amygdala and its relevance to acute stress-induced ethanol consumption in mice 母亲分离应激对小鼠扩展杏仁核cric系统的影响及其与急性应激诱导的乙醇消耗的相关性

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-21 DOI: 10.1016/j.alcohol.2025.11.004

Natalia Bonetti Bertagna , Cristiane Aparecida Favoretto , Ben Tagami Rodolpho , Thamires Righi , Cássio Morais Loss , Ingrid B.M. Morais , Talita A.M. Vrechi , Adolfo Garcia Erustes , Gustavo J.S. Pereira , Tarciso Tadeu Miguel , Fábio Cardoso Cruz

Maternal separation (MS) is an early-life stressor associated with increased vulnerability to alcohol use disorders (AUD) later in life, potentially through alterations in corticotropin-releasing factor (CRF) signaling in the extended amygdala—comprising the bed nucleus of the stria terminalis (BNST) and amygdala (AMY). This study investigated the long-term effects of MS on ethanol consumption and CRFergic signaling following acute stress, considering possible sex-dependent differences. C57BL/6J pups were subjected to the MS paradigm from postnatal days (PND) 1–14; controls remained undisturbed. On PND 45, mice underwent an Drinking in the Dark (DID) protocol for three weeks, followed by operant alcohol self-administration under a fixed ratio schedule. They were then tested under a progressive ratio (PR) reinforcement schedule. After PR, a subset of mice was randomly assigned to the Rat Exposure Test (RET), while a second subset of mice was kept naïve for it. Finally, a 4h-binge session was allowed for all the animals. Results showed that female groups, independent of MS stress, consumed more ethanol than male groups during DID. Male MS mice spent more time in the home chamber during RET, which was associated with increased number of reinforcements and active nose pokes during binge protocol. MS mice not exposed to RET showed increased CRF-binding protein in the AMY and reduced CRFR1 receptor in the BNST; RET exposure led to increased CRFR2 receptor expression in the AMY of MS mice. These findings suggest that MS alters alcohol consumption, particularly in response to acute stress, in a sex-dependent manner, and the CRFergic system of mice exposed chronically to this substance.

母亲分离（MS）是一种早期生活压力源，与生命后期酒精使用障碍（AUD）的易感性增加相关，可能通过扩展杏仁核（包括终纹（BNST）和杏仁核（AMY）的床核）中促肾上腺皮质激素释放因子（CRF）信号的改变。本研究考察了急性应激后MS对乙醇消耗和crferic信号的长期影响，并考虑了可能的性别依赖性差异。C57BL/6J幼崽在出生后1 ~ 14天接受MS模式；控制仍未受到干扰。在PND 45中，小鼠进行了为期三周的夜间饮酒（DID）方案，然后按照固定比例计划进行酒精自我给药。然后在递进比（PR）强化计划下进行测试。PR后，随机分配一组小鼠进行大鼠暴露试验（RET），而另一组小鼠则保持naïve。最后，所有的动物都被允许狂饮4小时。结果表明，在不受MS胁迫影响的情况下，雌鼠在DID过程中比雌鼠消耗更多的乙醇。在RET期间，雄性MS小鼠在家里的时间更长，这与暴食方案中增加的强化次数和主动戳鼻子有关。未暴露于RET的MS小鼠显示AMY中crf结合蛋白增加，BNST中CRFR1受体减少；RET暴露导致MS小鼠AMY中CRFR2受体表达增加。这些发现表明，多发性硬化症以性别依赖的方式改变了酒精摄入量，特别是对急性应激的反应，以及长期暴露于这种物质的小鼠的慢性代谢系统。

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引用次数: 0

Effects of alcohol use on the gut, inflammation, and organ injury: A summary of the 2025 Alcohol and Immunology Research Interest Group (AIRIG) meeting 酒精使用对肠道、炎症和器官损伤的影响：2025年酒精和免疫学研究兴趣小组（AIRIG）会议总结

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-20 DOI: 10.1016/j.alcohol.2025.11.005

Madison M. Tschann , J. Mark Brown , Summer L. Thompson , Anjali Kumari , Ashley Peer , Pranoti Mandrekar , Neil Romesh , Chueh-Lung Hwang , Samantha M. Yeligar , Elizabeth J. Kovacs , Mashkoor A. Choudhry

The 30th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held on June 21st, 2025, at the Hyatt Regency in New Orleans, Louisiana as a satellite symposium of the Research Society on Alcohol (RSA) and International Society for Biomedical Research on Alcoholism (ISBRA) joint meeting. The meeting was divided into two plenary sessions. The overall focus of this year's meeting was on the effects of alcohol on the gut microbial changes, inflammation, and organ injury.

酒精和免疫学研究兴趣小组（AIRIG）第30届年度会议于2025年6月21日在路易斯安那州新奥尔良的凯悦酒店举行，作为酒精研究学会（RSA）和国际酒精中毒生物医学研究学会（ISBRA）联合会议的卫星研讨会。会议分为两次全体会议。今年会议的总体重点是酒精对肠道微生物变化、炎症和器官损伤的影响。

引用次数: 0

Argument for the pharmacokinetically-informed preclinical researcher: A commentary for Alcohol 临床前研究人员对药代动力学知情的争论：对酒精的评论

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-17 DOI: 10.1016/j.alcohol.2025.11.003

Nicholas J. Grahame

The purpose of this commentary is to advocate for the importance of carefully considering ethanol pharmacokinetics when conducting preclinical studies involving alcohol consumption. Researchers working in this field commonly use alcohol drinking as a principle or ancillary measurement. However, the amount of alcohol consumed cannot substitute for an understanding of dose, which is an essential referent in any study involving pharmacology, especially in studies using 24-h, two-bottle choice access to alcohol. Dose is the critical variable for understanding potency and efficacy, for translating both across species (including to humans) and for accurately building on preclinical work using in vitro methodologies. Nonetheless, there is a wide variety of practices when it comes to consideration of the pharmacological relevance of alcohol intake measures. Notably, there are numerous published studies reporting intake rates for which blood ethanol concentrations (BECs) would either be zero or negligible, or would be so high as to be physiologically impossible. To combat these issues, the gold standard for understanding dose should be measurement of BEC. Where this is impractical or impossible, researchers must at a minimum carefully analyze rates of alcohol intake in their population against well-understood and easily modeled pharmacokinetic factors, such as rate of intake as it compares to rate of metabolism. Similar methods are increasingly apparent in clinical studies that use pharmacological modeling (so-called “eBAC”) along with measuring the rate of alcohol intake to estimate human BECs. In short, to make useful contributions to the study of alcohol drinking, authors should ensure that they are pharmacokinetically informed.

这篇评论的目的是提倡在进行涉及酒精消费的临床前研究时仔细考虑乙醇药代动力学的重要性。在这一领域工作的研究人员通常使用饮酒作为原则或辅助测量。然而，酒精消耗量不能代替对剂量的了解，这是任何涉及药理学的研究中必不可少的参考，特别是在使用24小时、两瓶选择获得酒精的研究中。剂量是理解效力和疗效的关键变量，是跨物种（包括对人类）转化的关键变量，也是使用体外方法准确建立临床前工作的关键变量。尽管如此，当涉及到酒精摄入测量的药理学相关性时，有各种各样的实践。值得注意的是，有许多已发表的研究报告称，血液乙醇浓度（BECs）要么为零，要么可以忽略不计，要么高到生理上不可能达到的程度。为了解决这些问题，理解剂量的黄金标准应该是BEC的测量。在不现实或不可能的情况下，研究人员必须至少仔细分析他们的人群中酒精摄入量的比率，以对照众所周知且易于建模的药代动力学因素，如摄入量与代谢率的比较。类似的方法在临床研究中越来越明显，使用药理学模型（所谓的“eBAC”）和测量酒精摄入量来估计人类的BECs。简而言之，为了对饮酒研究做出有用的贡献，作者应该确保他们了解药代动力学。

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引用次数: 0

Lateral hypothalamus CRFR1 regulation of binge drinking: Divergence along anterior-posterior axis 下丘脑外侧CRFR1对狂饮的调控：沿前后轴发散。

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-11 DOI: 10.1016/j.alcohol.2025.11.002

J.L. Ritchie , M.R. Eberle , J.A. Wojick , M.R. Campeau , L.S. Kooyman , T.E. Thiele , T.L. Kash

引用次数: 0

Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model 乙醇诱导人多能干细胞神经元、星形胶质细胞、小胶质细胞三培养模型的神经免疫失调和可溶性TREM2的产生。

IF 2.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol

Pub Date : 2025-11-07 DOI: 10.1016/j.alcohol.2025.10.006

Andrew J. Boreland , Yara Abbo , Xindi Li , Alessandro C. Stillitano , Siwei Zhang , Jubao Duan , Zhiping P. Pang , Ronald P. Hart

Alcohol use disorders (AUDs) affect substantial populations worldwide and increase the risk of developing cognitive impairments and alcohol-associated dementia. While chronic inflammatory signaling likely plays an important role in alcohol-associated neurological sequalae, the precise mechanisms underlying alcohol-associated neuropathology remain enigmatic. We hypothesize that alcohol leads to neuroimmune dysregulation among neurons, astrocytes, and microglia; and is perpetuated by innate immune signaling pathways involving cell-cell signaling. To investigate how alcohol dysregulates neuroimmune interactions in a human context, we constructed a triculture model comprising neurons, astrocytes, and microglia derived from human induced pluripotent stem cells. After exposure to ethanol, we observed significant differential gene expression relating to innate immune pathways, inflammation, and microglial activation. Microglial activation was confirmed with morphological analysis and expression of CD68, a lysosomal-associated membrane protein and marker for phagocytic microglial activation. A striking finding in our study was the elevation of TREM2 expression and, specifically, TREM2 alternatively spliced isoforms that are predicted to give rise to soluble TREM2. TREM2 loss-of-function variants have been reported to be a risk factor for Alzheimer's disease. These results suggest that ethanol exposure in the brain may lead to increased microglial activation and production of soluble isoform named TREM2²¹⁹ through alternate splicing. Deciphering the molecular and cellular mechanisms underpinning ethanol-related neuroimmune dysregulation within a human context promises to shed light on the etiology of AUD-related disorders, potentially contributing to the development of effective therapeutic strategies.

酒精使用障碍（AUDs）影响着世界各地的大量人群，并增加了发生认知障碍和酒精相关痴呆的风险。虽然慢性炎症信号可能在酒精相关的神经后遗症中起重要作用，但酒精相关神经病理学的确切机制仍然是谜。我们假设酒精导致神经元、星形胶质细胞和小胶质细胞之间的神经免疫失调；并且通过先天免疫信号传导途径包括细胞-细胞信号传导得以延续。为了研究酒精如何在人类环境中失调神经免疫相互作用，我们构建了一个由神经元、星形胶质细胞和源自人类诱导多能干细胞的小胶质细胞组成的三培养模型。暴露于乙醇后，我们观察到与先天免疫途径、炎症和小胶质细胞激活相关的显著差异基因表达。形态学分析和CD68的表达证实了小胶质细胞的激活，CD68是一种溶酶体相关的膜蛋白和吞噬小胶质细胞激活的标记物。在我们的研究中，一个惊人的发现是TREM2表达的升高，特别是TREM2的选择性剪接异构体，预计会产生可溶性TREM2。据报道，TREM2功能丧失变异是阿尔茨海默病的一个危险因素。这些结果表明，大脑中的乙醇暴露可能导致小胶质细胞激活增加，并通过交替剪接产生可溶性异构体TREM2219。在人类背景下，破译乙醇相关神经免疫失调的分子和细胞机制，有望揭示aud相关疾病的病因，可能有助于开发有效的治疗策略。

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引用次数: 0