Effect of Polyvinylpyrrolidone on Antioxidant and Antibacterial Activity of Silver Metal Nanoparticles: A Comparative Analysis

IF 0.8 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Proceedings of the National Academy of Sciences, India Section A: Physical Sciences Pub Date : 2024-08-08 DOI:10.1007/s40010-024-00882-y
B. Dinesh, Jagadeesha Poyya, Farhan Zameer, Lokesh Koodlur Sannegowda, Chandrashekhar G. Joshi, Anjanapura V. Raghu
{"title":"Effect of Polyvinylpyrrolidone on Antioxidant and Antibacterial Activity of Silver Metal Nanoparticles: A Comparative Analysis","authors":"B. Dinesh,&nbsp;Jagadeesha Poyya,&nbsp;Farhan Zameer,&nbsp;Lokesh Koodlur Sannegowda,&nbsp;Chandrashekhar G. Joshi,&nbsp;Anjanapura V. Raghu","doi":"10.1007/s40010-024-00882-y","DOIUrl":null,"url":null,"abstract":"<div><p>Nanotechnology research has advanced in the past two decades because of its tunable physicochemical properties. Among the wide range of metal-based nanoparticles, silver nanoparticles (AgNPs) have gained intense research prominence because of their peerless features such as excellent electrical conductivity, catalysis, and a broad range of promising bioactivities such as antioxidant, antibacterial, antifungal, anti-inflammatory, and anticancer effects. In attaining the colloidal stability of silver nanoparticles, capping plays an important role. These capping compounds are believed to provide dual functionality in the synthesis process, acting both as structure-directing and stabilizing agents. Polyvinylpyrrolidone (PVP) is a biocompatible, <i>p</i>H-stable, inert, non-toxic, temperature-resistant, and biodegradable polymer. In the present study, PVP capped silver nanoparticles are synthesized using glucose as a reducing agent, and studied the influence of PVP concentration on silver nanoparticles. Three different ratios of silver nitrate and PVP (1:1, 1:1.5, and 1:2) are taken for silver nanoparticle synthesis. Further, silver nanoparticles obtained are subjected to a series of examinations, including UV Spectrophotometry, SEM, X-Ray Diffraction Spectroscopy, Dynamic Light Scattering, and FTIR. The PVP capped silver nanoparticles are spherical, non-aggregated, polydisperse, and had a unimodal distribution, with diameters ranging from 40 to 100 nm. PVP capped silver nanoparticles are then subjected to antioxidant and antimicrobial activity investigation by spectrometry and agar well diffusion method respectively. The DPPH and the ABTS study revealed the radical scavenging activity of AgNPs. However, the PVP-capped silver nanoparticles did not show any antibacterial activity. This study showed the possibility of the application of PVP-capped AgNPs in the treatment of free radical-related diseases.</p></div>","PeriodicalId":744,"journal":{"name":"Proceedings of the National Academy of Sciences, India Section A: Physical Sciences","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the National Academy of Sciences, India Section A: Physical Sciences","FirstCategoryId":"103","ListUrlMain":"https://link.springer.com/article/10.1007/s40010-024-00882-y","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Nanotechnology research has advanced in the past two decades because of its tunable physicochemical properties. Among the wide range of metal-based nanoparticles, silver nanoparticles (AgNPs) have gained intense research prominence because of their peerless features such as excellent electrical conductivity, catalysis, and a broad range of promising bioactivities such as antioxidant, antibacterial, antifungal, anti-inflammatory, and anticancer effects. In attaining the colloidal stability of silver nanoparticles, capping plays an important role. These capping compounds are believed to provide dual functionality in the synthesis process, acting both as structure-directing and stabilizing agents. Polyvinylpyrrolidone (PVP) is a biocompatible, pH-stable, inert, non-toxic, temperature-resistant, and biodegradable polymer. In the present study, PVP capped silver nanoparticles are synthesized using glucose as a reducing agent, and studied the influence of PVP concentration on silver nanoparticles. Three different ratios of silver nitrate and PVP (1:1, 1:1.5, and 1:2) are taken for silver nanoparticle synthesis. Further, silver nanoparticles obtained are subjected to a series of examinations, including UV Spectrophotometry, SEM, X-Ray Diffraction Spectroscopy, Dynamic Light Scattering, and FTIR. The PVP capped silver nanoparticles are spherical, non-aggregated, polydisperse, and had a unimodal distribution, with diameters ranging from 40 to 100 nm. PVP capped silver nanoparticles are then subjected to antioxidant and antimicrobial activity investigation by spectrometry and agar well diffusion method respectively. The DPPH and the ABTS study revealed the radical scavenging activity of AgNPs. However, the PVP-capped silver nanoparticles did not show any antibacterial activity. This study showed the possibility of the application of PVP-capped AgNPs in the treatment of free radical-related diseases.

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
聚乙烯吡咯烷酮对金属银纳米粒子抗氧化和抗菌活性的影响:比较分析
在过去的二十年里,纳米技术研究因其可调整的物理化学特性而取得了长足的进步。在种类繁多的金属基纳米粒子中,银纳米粒子(AgNPs)因其卓越的导电性、催化性和广泛的生物活性(如抗氧化、抗菌、抗真菌、抗炎和抗癌作用)等无与伦比的特性而备受研究关注。要实现银纳米粒子的胶体稳定性,封端起着重要作用。据信,这些封端化合物在合成过程中具有双重功能,既是结构引导剂,又是稳定剂。聚乙烯吡咯烷酮(PVP)是一种生物相容性好、pH 值稳定、惰性、无毒、耐高温、可生物降解的聚合物。本研究以葡萄糖为还原剂合成了 PVP 封端的银纳米粒子,并研究了 PVP 浓度对银纳米粒子的影响。在合成银纳米粒子时,硝酸银和 PVP 采用了三种不同的比例(1:1、1:1.5 和 1:2)。然后,对获得的银纳米粒子进行一系列检测,包括紫外分光光度法、扫描电子显微镜、X 射线衍射光谱法、动态光散射法和傅立叶变换红外光谱法。PVP 封端的银纳米粒子呈球形,不聚集,多分散,呈单峰分布,直径在 40 至 100 nm 之间。然后,分别采用光谱法和琼脂井扩散法对 PVP 封端的银纳米粒子进行抗氧化和抗菌活性研究。DPPH 和 ABTS 研究显示了 AgNPs 的自由基清除活性。然而,PVP 封装的银纳米粒子没有显示出任何抗菌活性。这项研究表明,PVP 封装的银纳米粒子可用于治疗与自由基有关的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.60
自引率
0.00%
发文量
37
审稿时长
>12 weeks
期刊介绍: To promote research in all the branches of Science & Technology; and disseminate the knowledge and advancements in Science & Technology
期刊最新文献
Double Sequences of Bi-complex Numbers Estimation of Crustal Tilting from Petrotectonic Interpretation of Mesozone Granitoid and its Marginal Parts, Eastern Dharwar Craton, India Transition Temperature versus Formula Mass of Selected High-TC Oxide Superconductors: A Step Closure to Room Temperature Superconductivity A Study on Countability in the Context of Multiset Topological Spaces On Machining Profile Accuracy in the Modified Electrochemical Machining Process
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1