A. G. Goncharov, V. V. Shupletsova, N. D. Gazatova, O. B. Melashchenko, K. A. Yurova, L. S. Litvinova
{"title":"Cord Blood as a Trophic-Growth Additive for Culture Work","authors":"A. G. Goncharov, V. V. Shupletsova, N. D. Gazatova, O. B. Melashchenko, K. A. Yurova, L. S. Litvinova","doi":"10.1134/s1990519x24700299","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The review analyzes the results of modern high-tech research on the use of umbilical cord blood serum (plasma) as an additive to culture media for growing cell cultures. Since culture media are a key factor in cell culture, this review examines the composition and properties of the main culture media used in cell biology and regenerative medicine. The authors paid special attention to growth factors; the functional characteristics of the main families of these polypeptides are described (fibroblast growth factors, epidermal growth factors, transforming growth factors, growth differentiation, epidermal growth factors, endothelial cell growth factors, hematopoietic growth factors, etc.). It has been noted that one of the promising sources of growth factors is umbilical cord blood serum (plasma). The review presents the main technologies for obtaining umbilical cord blood, as well as systematizing studies reflecting the content of growth factors, cytokines, exosomes, and mRNA in umbilical cord blood; experimental data on the use of umbilical cord blood serum as an additive to culture media for growing various cultures of animal cells are described. Human cord blood serum, compared to animal sources, is an affordable, safe product containing high levels of bioactive molecules. For its widespread introduction as an additive to culture media, it is necessary to develop standards for the production and testing of this product.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"73 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x24700299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The review analyzes the results of modern high-tech research on the use of umbilical cord blood serum (plasma) as an additive to culture media for growing cell cultures. Since culture media are a key factor in cell culture, this review examines the composition and properties of the main culture media used in cell biology and regenerative medicine. The authors paid special attention to growth factors; the functional characteristics of the main families of these polypeptides are described (fibroblast growth factors, epidermal growth factors, transforming growth factors, growth differentiation, epidermal growth factors, endothelial cell growth factors, hematopoietic growth factors, etc.). It has been noted that one of the promising sources of growth factors is umbilical cord blood serum (plasma). The review presents the main technologies for obtaining umbilical cord blood, as well as systematizing studies reflecting the content of growth factors, cytokines, exosomes, and mRNA in umbilical cord blood; experimental data on the use of umbilical cord blood serum as an additive to culture media for growing various cultures of animal cells are described. Human cord blood serum, compared to animal sources, is an affordable, safe product containing high levels of bioactive molecules. For its widespread introduction as an additive to culture media, it is necessary to develop standards for the production and testing of this product.
期刊介绍:
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.