Phenylpropanoids with Anti-Inflammatory Effects from the Roots of Platycodon grandiflorus

IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL Chemistry of Natural Compounds Pub Date : 2024-08-06 DOI:10.1007/s10600-024-04402-7
Yang Yu, Lan Ding, Ren-Nai Yang, Liang-Ping Zha, Ju-Tao Wang, Shuang-Ying Gui
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Abstract

Two new phenylpropanoids, plagnans (1) and plaganoid (2), along with five known phenylpropanoids, including an enantiomeric mixture (compound 3) were isolated from the roots of Platycodon grandiflorus. Meanwhile, their structures were elucidated by analyzing the spectroscopic data, including NMR, HR-ESI-MS, ECD (ICD), and X-ray analysis. Although all isolates were evaluated for their anti-inflammatory activities, and of them exhibited moderate activities, with IC50 values of around 27.5 μM.

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桔梗根中具有抗炎作用的苯丙酸类化合物
研究人员从桔梗的根中分离出了两种新的苯丙酮类化合物:plagnans (1) 和 plaganoid (2),以及五种已知的苯丙酮类化合物,包括一种对映体混合物(化合物 3)。同时,通过分析光谱数据(包括 NMR、HR-ESI-MS、ECD(ICD)和 X 射线分析)阐明了它们的结构。尽管对所有分离物进行了抗炎活性评估,但它们都表现出中等活性,IC50 值约为 27.5 μM。
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来源期刊
Chemistry of Natural Compounds
Chemistry of Natural Compounds 化学-有机化学
CiteScore
1.40
自引率
25.00%
发文量
265
审稿时长
7.8 months
期刊介绍: Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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