A new pyridine, 4-(1′-acetoxy-2′-p-hydroxyphenylethyl)-2-methyl-pyridine (1) and seven known compounds (2–8) were isolated from the roots of Merremia umbellata. The structure of the new pyridine was elucidated by chemical and physical evidence.
A new pyridine, 4-(1′-acetoxy-2′-p-hydroxyphenylethyl)-2-methyl-pyridine (1) and seven known compounds (2–8) were isolated from the roots of Merremia umbellata. The structure of the new pyridine was elucidated by chemical and physical evidence.
New derivatives of lupane triterpenoids containing a pyrrole or N-vinylpyrrole ring condensed with ring A and a C-28 amide or methyl group in the triterpenoid were synthesized by the reaction of 3-ketoximes based on betulonic acid or lupenone amides with acetylene in KOH–DMSO superbase solution.
New amido-derivatives of 5-fluorouracil were synthesized. Their cytotoxic activity was studied. Antiproliferative activity was found for all 5-fluorouracil derivatives. 2,2′-[5-Fluoro-2,4-dioxopyrimidine-1,3(2H,4H)-diyl]bis[N-(2,6-dimethylphenyl)acetamide] (3e) exhibited the greatest dose-dependent cytotoxicity on HeLa cells; 2,2′ -[5-fluoro-2,4-dioxopyrimidine-1,3(2H,4H)-diyl]bis[N-(2,4-dimethylphenyl)acetamide] (3c), on KML and AKAT cells.
Products from the pinacol rearrangement of lappaconine and lappaconitine were studied. A series of esters based on them was obtained.
Reactions of N-deacetyllappaconitine (2) with ethanesulfonyl chloride and chloroacetyl chloride under various conditions were studied. The optimal conditions for the reactions were found. The structures of the obtained compounds were established using IR and NMR spectroscopy and an X-ray crystal structure analysis (XSA). Two crystalline polymorphic forms of the ethanesulfonamide derivative of lappaconitine that grew from MeOH and CHCl3 were studied by XSAs.
Lipids including fatty acids and lipophilic and volatile compounds isolated from leaves, flowers, and fruit of freshly collected Ferula tenuisecta Korovin ex Pavlov (Apiaceae) were studied for the first time. Lipids from leaves included the major (Z,Z,Z)-octadeca-9,12,15-trienoic (linolenic) acid (51.7%) and its homolog identified for the first time, (Z,Z,Z)-hexadeca-7,10,13-trienoic acid (13.5%), which confirmed that this species belonged to a group containing 16:3 acid.
Data on the isolation of antioxidant peptides from sheep brain albumin hydrolysate are presented. The sheep brain albumin hydrolysates were separated by anion-exchange chromatography over DEAE-650M. Five peaks for peptides with molecular mass <20 kDa were obtained. The peptides contained large amounts of hydrophobic, hydrophilic, and acidic amino acids and large amounts of His, Gly, Glu, Phe, Val, Tyr, Asp, and Leu, which possessed the highest antioxidant activity. The removal of ABTS free radicals in NaCl (0.2 M) was 82.36 ± 1.16%; chelating ability for Cu ions, 57.93 ± 0.22%, chelating ability for Fe ions, 65.95 ± 1.00%. LC-MS/MS identified two spots in two-dimensional gel electrophoresis (2-DE). Spots 15 and 27 contained the 14,728 kDa hybrid protein ubiquitin with eL40 ribosomal protein, which consisted of 51.6% and 43%, respectively.
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