Pub Date : 2026-02-25DOI: 10.1007/s10600-026-04900-w
U. A. Kurbonov, Sh. N. Zhurakulov, V. I. Vinogradova, K. K. Turgunov, Yu. T. Mirzaeva, Z. D. Allaniyazova, B. Tashkhodzhaev, B. B. Shodmonov
New dimer compounds containing indole-quinoline moieties were synthesized from 2-chloro-6(7)-methyl-3-formylquinoline and tryptamine via a Pictet–Spengler reaction. Their relaxant activity was studied. The structures of the obtained compounds were confirmed using IR, mass, and NMR spectral data and X-ray crystal structure analyses.
{"title":"Synthesis of New Hybrid Compounds Containing Indole-Quinoline Moieties","authors":"U. A. Kurbonov, Sh. N. Zhurakulov, V. I. Vinogradova, K. K. Turgunov, Yu. T. Mirzaeva, Z. D. Allaniyazova, B. Tashkhodzhaev, B. B. Shodmonov","doi":"10.1007/s10600-026-04900-w","DOIUrl":"10.1007/s10600-026-04900-w","url":null,"abstract":"<p>New dimer compounds containing indole-quinoline moieties were synthesized from 2-chloro-6(7)-methyl-3-formylquinoline and tryptamine via a Pictet–Spengler reaction. Their relaxant activity was studied. The structures of the obtained compounds were confirmed using IR, mass, and NMR spectral data and X-ray crystal structure analyses.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"117 - 124"},"PeriodicalIF":0.9,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10600-026-04916-2
Audrey Ashleeynus Allhin, Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Mohd Hafiz Arzmi, Betul Apaydin Yildirim
{"title":"Chemical Insights into the Volatile Oil of Beilschmiedia dictyoneura and Acetylcholinesterase Inhibitory Activity","authors":"Audrey Ashleeynus Allhin, Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Mohd Hafiz Arzmi, Betul Apaydin Yildirim","doi":"10.1007/s10600-026-04916-2","DOIUrl":"10.1007/s10600-026-04916-2","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"178 - 180"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10600-026-04918-0
B. S. Okhundedaev, Kh. M. Bobakulov, Sh. R. Rakhimberdieva, S. Z. Nishanbaev, A. M. Nigmatullaev, S. A. Sasmakov, Sh. S. Azimova
{"title":"Essential Oil from Artemisia glanduligera and its Antimicrobial Activity","authors":"B. S. Okhundedaev, Kh. M. Bobakulov, Sh. R. Rakhimberdieva, S. Z. Nishanbaev, A. M. Nigmatullaev, S. A. Sasmakov, Sh. S. Azimova","doi":"10.1007/s10600-026-04918-0","DOIUrl":"10.1007/s10600-026-04918-0","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"184 - 186"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10600-026-04919-z
E. M. Suleimen, G. K. Mamytbekova, D. K. Nurkadyrov, R. V. Doudkin, P. G. Gorovoy, S. A. Ross
{"title":"Composition and Biological Activity of Essential Oil from Peucedanum coreanum","authors":"E. M. Suleimen, G. K. Mamytbekova, D. K. Nurkadyrov, R. V. Doudkin, P. G. Gorovoy, S. A. Ross","doi":"10.1007/s10600-026-04919-z","DOIUrl":"10.1007/s10600-026-04919-z","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"187 - 189"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10600-026-04920-6
E. M. Suleimen, P. G. Gorovoy
{"title":"Constituent Composition and Biological Activity of Essential Oil from Tripolium pannonicum","authors":"E. M. Suleimen, P. G. Gorovoy","doi":"10.1007/s10600-026-04920-6","DOIUrl":"10.1007/s10600-026-04920-6","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"190 - 191"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrodia elata (Orchidaceae) is a material used for medicine, food, and cosmetics in China. Two new alkaloids, 1,7-bis(4-hydroxybenzyl)-1,7-dihydro-6H-purin-6-one (1) and 1,9-bis(4-hydroxybenzyl)-1,9-dihydro-6H-purin-6-one (2), five known alkaloids, (–)-(R)-4-(2-hydroxy-2-quinolin-4-ylethyl)phenol ((–)-3), (+)-(S)-4-(2-hydroxy-2-quinolin-4-ylethyl)phenol ((+)-3), 1-(4-hydroxyphenyl)-β-carboline (4), p-topolin riboside (5), and cannabisin F (6), and nine other compounds (7–15), were isolated from the rhizomes, peduncles, and inflorescences of Gastrodia elata, a waste collected after seed harvesting. The chemical structures of these new compounds were determined by MS and NMR spectroscopic data. These isolated alkaloids were evaluated for their cholinesterase inhibitory activity and collagen I secretion-promoting activity. Compound 2 inhibited acetylcholinesterase (AChE) with an IC50 value of 19.8 ± 1.8 μM, whereas compound 4 exhibited an inhibitory effect on AChE with an IC50 value of 24.7 ± 3.2 μM, and on butyrylcholinesterase (BuChE) with an IC50 value of 0.84 ± 0.06 μM. At a concentration of 0.1 μM, compounds (–)-3, (+)-3, and 5 exhibited significant collagen I secretion-promoting activity in human dermal fibroblast adults (HDFa). These active compounds have potential for the development of neuroprotective drugs or antiaging cosmetics.
{"title":"Chemical Constituents from Gastrodia elata with Promoting Collagen I Production and Cholinesterase Inhibitory Activities","authors":"Xiu-Yun Cha, Dong-Bao Hu, Xue Bai, Hui Yan, Yi-Fang Chen, Ying-Li Yang, Ji-Feng Luo, Jun Yang, Xiao-Yan Duan, Chang-Fei Zhang, Jing-Hua Yang, Meng-Hua Tian, Yun-Song Wang, Yue-Hu Wang","doi":"10.1007/s10600-026-04892-7","DOIUrl":"10.1007/s10600-026-04892-7","url":null,"abstract":"<p>Gastrodia elata (Orchidaceae) is a material used for medicine, food, and cosmetics in China. Two new alkaloids, 1,7-bis(4-hydroxybenzyl)-1,7-dihydro-6<i>H</i>-purin-6-one (<b>1</b>) and 1,9-bis(4-hydroxybenzyl)-1,9-dihydro-6<i>H</i>-purin-6-one (<b>2</b>), five known alkaloids, (–)-(<i>R</i>)-4-(2-hydroxy-2-quinolin-4-ylethyl)phenol (<b>(</b>–<b>)-3</b>), (+)-(S)-4-(2-hydroxy-2-quinolin-4-ylethyl)phenol (<b>(+)-3</b>), 1-(4-hydroxyphenyl)-<i>β</i>-carboline (<b>4</b>), <i>p</i>-topolin riboside (<b>5</b>), and cannabisin F (<b>6</b>), and nine other compounds (<b>7–15</b>), were isolated from the rhizomes, peduncles, and inflorescences of <i>Gastrodia elata</i>, a waste collected after seed harvesting. The chemical structures of these new compounds were determined by MS and NMR spectroscopic data. These isolated alkaloids were evaluated for their cholinesterase inhibitory activity and collagen I secretion-promoting activity. Compound <b>2</b> inhibited acetylcholinesterase (AChE) with an IC<sub>50</sub> value of 19.8 ± 1.8 μM, whereas compound <b>4</b> exhibited an inhibitory effect on AChE with an IC<sub>50</sub> value of 24.7 ± 3.2 μM, and on butyrylcholinesterase (BuChE) with an IC<sub>50</sub> value of 0.84 ± 0.06 μM. At a concentration of 0.1 μM, compounds <b>(</b>–<b>)-3</b>, <b>(+)-3</b>, and <b>5</b> exhibited significant collagen I secretion-promoting activity in human dermal fibroblast adults (HDFa). These active compounds have potential for the development of neuroprotective drugs or antiaging cosmetics.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"78 - 86"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1007/s10600-026-04915-3
Le D. Chac, Bui B. Thinh
{"title":"Chemical Composition and Antimicrobial Activity of Essential Oil from Vernonia arborea","authors":"Le D. Chac, Bui B. Thinh","doi":"10.1007/s10600-026-04915-3","DOIUrl":"10.1007/s10600-026-04915-3","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"175 - 177"},"PeriodicalIF":0.9,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1007/s10600-026-04899-0
T. N. Kaypnazarov, A. R. Khurramov, F. A. Kengesbaeva, Kh. M. Bobakulov, T. Kh. Naubeev, N. Sh. Ramazonov, F. Kh. Allaberdiev
The known compounds cyclosieversioside E (2) and cyclounifolioside B (3) and the new cycloartane glycoside macronoside A (1) or 16-O-acetyl-20R,24S-epoxycycloartane-3β,6α,16β,25-tetraol 3-O-β-D-xylopyranoside were isolated from roots of the plant Astragalus macronyx. The structure of the last was proved based on chemical transformations, 1H NMR and 13C NMR data, and 2D spectra (HMBC, HSQC, COSY, ROESY).
从植物黄芪的根中分离得到已知化合物环紫叶苷E(2)和环紫叶苷B(3)，以及新的环紫叶苷宏苷A(1)或16- o -乙酰基- 20r， 24s -环氧环紫叶苷-3β，6α,16β，25-四醇3- o -β- d -木pyranoside。通过化学转化、1H NMR和13C NMR数据以及二维光谱（HMBC， HSQC， COSY， ROESY）证实了最后一种化合物的结构。
{"title":"New Cycloartane Glycoside from Astragalus macronyx","authors":"T. N. Kaypnazarov, A. R. Khurramov, F. A. Kengesbaeva, Kh. M. Bobakulov, T. Kh. Naubeev, N. Sh. Ramazonov, F. Kh. Allaberdiev","doi":"10.1007/s10600-026-04899-0","DOIUrl":"10.1007/s10600-026-04899-0","url":null,"abstract":"<p>The known compounds cyclosieversioside E (<b>2</b>) and cyclounifolioside B (<b>3</b>) and the new cycloartane glycoside macronoside A (<b>1</b>) or 16-<i>O</i>-acetyl-20<i>R</i>,24<i>S</i>-epoxycycloartane-3<i>β</i>,6<i>α</i>,16<i>β</i>,25-tetraol 3-<i>O</i>-<i>β</i>-D-xylopyranoside were isolated from roots of the plant <i>Astragalus macronyx</i>. The structure of the last was proved based on chemical transformations, <sup>1</sup>H NMR and <sup>13</sup>C NMR data, and 2D spectra (HMBC, HSQC, COSY, ROESY).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"62 1","pages":"114 - 116"},"PeriodicalIF":0.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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