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Antimicrobial and Cytotoxic Activity of Imidazole and Thiazole Analogs of Polycarpine and Polycarpaurine C
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-04-01 DOI: 10.1007/s10600-025-04643-0
Yu. E. Sabutski, S. M. Kovach, N. N. Balaneva, K. L. Borisova, E. A. Chingizova, E. S. Menchinskaya, A. L. Burylova, A. R. Chingizov, B. P. Mashnev, D. N. Pelageev

Analogs of the alkaloids polycarpine and polycarpaurine C, metabolites of marine ascidians of the genus Polycarpa, were synthesized. Their cytotoxic and antimicrobial activities were comparatively analyzed. A chloro-containing analog of polycarpaurine C was shown to exhibit high antibacterial activity against Staphylococcus aureus and Escherichia coli superior to that of gentamicin. Polycarpaurine C and its thioanalogs strongly inhibited biofilm formation by the studied microorganisms.

合成了生物碱多卡品和多卡品C的类似物，它们是多卡品属海洋腹足类的代谢物。对它们的细胞毒性和抗菌活性进行了比较分析。结果表明，聚卡泊林 C 的含氯类似物对金黄色葡萄球菌和大肠杆菌具有很强的抗菌活性，优于庆大霉素。聚卡泊林 C 及其硫代类似物可强烈抑制所研究微生物的生物膜形成。
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引用次数: 0
Phenolic Compounds from Artemisia persica
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-29 DOI: 10.1007/s10600-025-04657-8
J. F. Umaraliev, A. A. Ganiev, A. Turak, N. B. Begmatov, Bo Zhao, Kh. M. Bobakulov, N. D. Abdullaev, R. Abdulla, J. Zhao
{"title":"Phenolic Compounds from Artemisia persica","authors":"J. F. Umaraliev,&nbsp;A. A. Ganiev,&nbsp;A. Turak,&nbsp;N. B. Begmatov,&nbsp;Bo Zhao,&nbsp;Kh. M. Bobakulov,&nbsp;N. D. Abdullaev,&nbsp;R. Abdulla,&nbsp;J. Zhao","doi":"10.1007/s10600-025-04657-8","DOIUrl":"10.1007/s10600-025-04657-8","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"388 - 391"},"PeriodicalIF":0.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipids from Seseli condensatum in Various Phenological Phases
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-29 DOI: 10.1007/s10600-025-04647-w
N. P. Rabdanova, B. M. Zhigmittsyrenova, Zh. A. Tykheev, V. V. Taraskin
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引用次数: 0
Design and Synthesis of Rupestonic Acid Derivatives and Assessment of Their Cytotoxic Activity
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-29 DOI: 10.1007/s10600-025-04632-3
R. Y. Zhu, Kh. Bozorov, H. A. Aisa, J. Y. Zhao

Twenty novel rupestonic acid amides were designed and synthesized. Their cytotoxic activity was assessed against four human cancer cell lines (HeLa, HT-29, A549, and HepG2). Amide derivative 2e exhibited cytotoxic activity against A549 (IC50 = 4.73 μM) and HT-29 cells (IC50 = 7.55 μM); 1a, against HeLa cells (IC50 = 13.95 μM); 1d, against HepG2 cells (IC50 = 11.12 μM).

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引用次数: 0
Triterpenoids and Sterols from Stems of Primorsky Grape Variety Alpha
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-28 DOI: 10.1007/s10600-025-04663-w
E. A. Santalova, N. D. Pokhilo, K. A. Drozdov, E. A. Chingizova, E. A. Pislyagin, A. N. Emelyanov, S. A. Fedoreyev
{"title":"Triterpenoids and Sterols from Stems of Primorsky Grape Variety Alpha","authors":"E. A. Santalova,&nbsp;N. D. Pokhilo,&nbsp;K. A. Drozdov,&nbsp;E. A. Chingizova,&nbsp;E. A. Pislyagin,&nbsp;A. N. Emelyanov,&nbsp;S. A. Fedoreyev","doi":"10.1007/s10600-025-04663-w","DOIUrl":"10.1007/s10600-025-04663-w","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"405 - 407"},"PeriodicalIF":0.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites of Zingiber oligophyllum and Their Antiliver Cancer Activity
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-28 DOI: 10.1007/s10600-025-04652-z
Der-An Tsao, Hsin-Yu Chung, Hui-Mei Su, Chung-Yi Chen
{"title":"Metabolites of Zingiber oligophyllum and Their Antiliver Cancer Activity","authors":"Der-An Tsao,&nbsp;Hsin-Yu Chung,&nbsp;Hui-Mei Su,&nbsp;Chung-Yi Chen","doi":"10.1007/s10600-025-04652-z","DOIUrl":"10.1007/s10600-025-04652-z","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"375 - 377"},"PeriodicalIF":0.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Nematicide Activities of β-Sitosterol Ester Derivatives
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-28 DOI: 10.1007/s10600-025-04662-x
Xin Xia, Xinyue Liu, Guang Yang, Sihong Wang, Li Hua Jin
{"title":"Synthesis and Nematicide Activities of β-Sitosterol Ester Derivatives","authors":"Xin Xia,&nbsp;Xinyue Liu,&nbsp;Guang Yang,&nbsp;Sihong Wang,&nbsp;Li Hua Jin","doi":"10.1007/s10600-025-04662-x","DOIUrl":"10.1007/s10600-025-04662-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"401 - 404"},"PeriodicalIF":0.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Profile and Anti-Inflammatory Activity of Volatile Oil from Coreopsis basalis Flowers 拟南芥花挥发油的化学成分和抗炎活性
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-28 DOI: 10.1007/s10600-025-04656-9
Hai-Tao Zhang, Jing Zuo
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引用次数: 0
α-Glucosidase Inhibitory and Antioxidant Constituents from Rosa roxburghii 蔷薇中的α-葡萄糖苷酶抑制剂和抗氧化剂成分
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-28 DOI: 10.1007/s10600-025-04653-y
Lu Yang, Lijuan Xiang, Na Yang, Xuezhi Zhang, Ke Ren, Xingxiang Long, Ying Zhou, Xin Yin
{"title":"α-Glucosidase Inhibitory and Antioxidant Constituents from Rosa roxburghii","authors":"Lu Yang,&nbsp;Lijuan Xiang,&nbsp;Na Yang,&nbsp;Xuezhi Zhang,&nbsp;Ke Ren,&nbsp;Xingxiang Long,&nbsp;Ying Zhou,&nbsp;Xin Yin","doi":"10.1007/s10600-025-04653-y","DOIUrl":"10.1007/s10600-025-04653-y","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 2","pages":"378 - 380"},"PeriodicalIF":0.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Mono- and Diamines of Diphenyl Ether Hernandial from Functionalized Anilines
IF 0.8 4区 化学 Q4 CHEMISTRY, MEDICINAL
Chemistry of Natural Compounds
Pub Date : 2025-03-28 DOI: 10.1007/s10600-025-04640-3
I. M. Sakhautdinov, G. V. Remezova, G. F. Sakhautdinova

A synthetic method for amines with a diphenyloxide fragment based on aniline derivatives was developed. Trends in the formation of mono- and diamines of the diphenyl ether hernandial were studied as a function of the nature of the substituent on the phenylamine aromatic ring.

以苯胺衍生物为基础，开发了一种具有二苯氧基片段的胺的合成方法。根据苯胺芳香环上取代基的性质，研究了二苯醚庚二醛单胺和二胺的形成趋势。
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引用次数: 0
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