{"title":"A New Cyclic Peptide from Betel Nut Endophytic Fungus Alternaria sp. RW-AL","authors":"Wu Ruan, Qing-Yun Ma, Jiao-Cen Guo, Qing-Yi Xie, Li Yang, Hao-Fu Dai, You-Geng Wu, You-Xing Zhao","doi":"10.1007/s10600-024-04413-4","DOIUrl":null,"url":null,"abstract":"<p>A new cyclic peptide alternarin A (<b>1</b>), along with seven known compounds, alternariol (<b>2</b>), sulfated derivative of alternariol (<b>3</b>), alternariol methyl ether (<b>4</b>), altenuene (<b>5</b>), 2,5-dimethyl-7-hydroxychromone (<b>6</b>), diaporthein A (<b>7</b>), isopterocarpolone (<b>8</b>), were isolated from the betel nut endophytic fungus <i>Alternaria</i> sp. RW-AL. The structure of <b>1</b> was elucidated by 1D and 2D NMR spectra as well as HR-ESI-MS analysis. Compounds <b>1</b>, <b>4</b>, and <b>5</b> showed definite antibacterial activities against <i>Staphylococcus aureus</i> ATCC 6538 and <i>Bacillus subtilis</i> ATCC 6633.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-024-04413-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
A new cyclic peptide alternarin A (1), along with seven known compounds, alternariol (2), sulfated derivative of alternariol (3), alternariol methyl ether (4), altenuene (5), 2,5-dimethyl-7-hydroxychromone (6), diaporthein A (7), isopterocarpolone (8), were isolated from the betel nut endophytic fungus Alternaria sp. RW-AL. The structure of 1 was elucidated by 1D and 2D NMR spectra as well as HR-ESI-MS analysis. Compounds 1, 4, and 5 showed definite antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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