Recent progress in the asymmetric construction of CN, CO, and CS bonds using chiral sulfinamide reagents

Abstract

Chiral sulfinamides have emerged as versatile tools in various asymmetric reactions, especially in the generation of chiral amines through asymmetric CC bond formation reactions involving chiral sulfinyl imines derived from sulfinamides and aldehyde or ketones. The prospect of employing sulfinamide auxiliaries in stereoselective carbon–heteroatom bond formation reactions has received considerable attention. This review examines recent advancements in stereoselective reactions involving chiral sulfinamide reagents, focusing on CN, CO, and CS bond formation reactions. The article elucidates the mechanisms and stereocontrol aspects underlying these asymmetric reactions, highlighting their utility in the synthesis of bioactive compounds.