Sustained-Release of Antigens and CpG-DNA using Temperature-Responsive Biodegradable Injectable Polymers: Performance on Induction of Immune Responses (Adv. Therap. 8/2024)
Yuta Yoshizaki, Kenta Horii, Nobuo Murase, Akinori Kuzuya, Yuichi Ohya
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引用次数: 0
Abstract
Temperature-responsive biodegradable injectable polymer (IP) hydrogel attains sustained-release of antigens and adjuvants persistently stimulating antigen-presenting cells. The degradability of IP hydrogels is adjustable by using tri-PCG whose termini are chemically modified. The release behavior of antigens and adjuvants is controlled by changing the composition of the injectable polymer system. Cellular and humoral responses induced by IP hydrogel vaccine formulations are investigated and discussed herein. More details can be found in article 2300296 by Yuta Yoshizaki, Yuichi Ohya, and co-workers.
温度响应型生物可降解注射聚合物（IP）水凝胶可持续释放抗原和佐剂，持续刺激抗原递呈细胞。IP 水凝胶的降解性可以通过使用端部经过化学修饰的三氯化萘来调节。抗原和佐剂的释放行为可通过改变可注射聚合物系统的成分来控制。本文对 IP 水凝胶疫苗制剂诱导的细胞和体液反应进行了研究和讨论。更多详情可参阅 Yuta Yoshizaki、Yuichi Ohya 及合作者的文章 2300296。
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