Martyna Krzykawska-Serda , Qian Feng , Maciej Serda
{"title":"Score a goal with buckyballs: Hypoxia-sensitive [70]fullerene nanotherapeutics","authors":"Martyna Krzykawska-Serda , Qian Feng , Maciej Serda","doi":"10.1016/j.matt.2024.05.039","DOIUrl":null,"url":null,"abstract":"<div><p>Li et al. reported the development and application of a novel hypoxia-sensitive fullerene-based nanotherapeutic system for photodynamic therapy in cancer treatment. This system integrates a [70]fullerene scaffold with amino-modified cyclodextrin and the hypoxia-activatable anticancer prodrug tirapazamine, enhanced with tumor-targeting peptides and disulfide bond donors. The created fullerene nanomaterial exhibits selective accumulation in tumor tissues, facilitated by its enhanced water solubility and targeted specificity.</p></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"7 8","pages":"Pages 2711-2713"},"PeriodicalIF":17.5000,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Matter","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590238524002649","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Li et al. reported the development and application of a novel hypoxia-sensitive fullerene-based nanotherapeutic system for photodynamic therapy in cancer treatment. This system integrates a [70]fullerene scaffold with amino-modified cyclodextrin and the hypoxia-activatable anticancer prodrug tirapazamine, enhanced with tumor-targeting peptides and disulfide bond donors. The created fullerene nanomaterial exhibits selective accumulation in tumor tissues, facilitated by its enhanced water solubility and targeted specificity.
期刊介绍：
Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content.
Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.
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