Young-Hee Kim , Dae-Cheol Choi , Dae-Won Ki , Ji-Yul Kim , Jae-Hyoung Song , Hyun-Jeong Ko , In-Kyoung Lee , Bong-Sik Yun
{"title":"A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity","authors":"Young-Hee Kim , Dae-Cheol Choi , Dae-Won Ki , Ji-Yul Kim , Jae-Hyoung Song , Hyun-Jeong Ko , In-Kyoung Lee , Bong-Sik Yun","doi":"10.1016/j.phytol.2024.08.005","DOIUrl":null,"url":null,"abstract":"<div><p>Several species within the genus <em>Phellinus</em> are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (<strong>1</strong>), and a known neo-lignan (<strong>2</strong>) were isolated from the culture broth of <em>P</em>. <em>linteus</em>. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds <strong>1</strong> and <strong>2</strong> exhibited anti-viral activity against DENV-2, with IC<sub>50</sub> values of 1.45 and 2.15 µM, respectively.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 43-46"},"PeriodicalIF":1.3000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001216","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), and a known neo-lignan (2) were isolated from the culture broth of P. linteus. The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC50 values of 1.45 and 2.15 µM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
