{"title":"End-to-end process flowsheet modeling for biopharmaceutical production: current state and future potential","authors":"","doi":"10.1016/j.coche.2024.101044","DOIUrl":null,"url":null,"abstract":"<div><p>As the biopharmaceutical industry advances to meet the pressures of an expanding product portfolio and global demand, it will continue to face new challenges while concurrently implementing Quality-by-Design principles. At this forefront, flowsheet modeling frameworks will become increasingly important <em>in silico</em> decisional tools during the process design phase. Flowsheet models further enable screening of process configurations, evaluation of technological alternatives, and identification and alleviation of potential bottlenecks within the context of technoeconomic and environmental impact studies. This review summarizes the recent literature on flowsheet methodologies within the monoclonal antibody sector. Key gaps and assumptions, primarily in the simulation of upstream production, present in current flowsheet approaches are examined. Strategies to overcome the identified assumptions are presented, involving the integration of higher resolution unit operation models to improve the accuracy of process assessments by incorporating biologically relevant constraints while maintaining computational feasibility.</p></div>","PeriodicalId":292,"journal":{"name":"Current Opinion in Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":8.0000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Chemical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211339824000455","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
As the biopharmaceutical industry advances to meet the pressures of an expanding product portfolio and global demand, it will continue to face new challenges while concurrently implementing Quality-by-Design principles. At this forefront, flowsheet modeling frameworks will become increasingly important in silico decisional tools during the process design phase. Flowsheet models further enable screening of process configurations, evaluation of technological alternatives, and identification and alleviation of potential bottlenecks within the context of technoeconomic and environmental impact studies. This review summarizes the recent literature on flowsheet methodologies within the monoclonal antibody sector. Key gaps and assumptions, primarily in the simulation of upstream production, present in current flowsheet approaches are examined. Strategies to overcome the identified assumptions are presented, involving the integration of higher resolution unit operation models to improve the accuracy of process assessments by incorporating biologically relevant constraints while maintaining computational feasibility.
期刊介绍:
Current Opinion in Chemical Engineering is devoted to bringing forth short and focused review articles written by experts on current advances in different areas of chemical engineering. Only invited review articles will be published.
The goals of each review article in Current Opinion in Chemical Engineering are:
1. To acquaint the reader/researcher with the most important recent papers in the given topic.
2. To provide the reader with the views/opinions of the expert in each topic.
The reviews are short (about 2500 words or 5-10 printed pages with figures) and serve as an invaluable source of information for researchers, teachers, professionals and students. The reviews also aim to stimulate exchange of ideas among experts.
Themed sections:
Each review will focus on particular aspects of one of the following themed sections of chemical engineering:
1. Nanotechnology
2. Energy and environmental engineering
3. Biotechnology and bioprocess engineering
4. Biological engineering (covering tissue engineering, regenerative medicine, drug delivery)
5. Separation engineering (covering membrane technologies, adsorbents, desalination, distillation etc.)
6. Materials engineering (covering biomaterials, inorganic especially ceramic materials, nanostructured materials).
7. Process systems engineering
8. Reaction engineering and catalysis.