Xiao-hui Sun , Wen-jian Gu , Tong-tong Min , Ya-mei Zhang , Pu-zhao Zhang
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引用次数: 0
Abstract
Two new pregnane alkaloids, named N,N-dimethylamino-3α-tigloylamino-pregn-5-ene (1) and 3α-N-methylamino-pregn-5, 14, 16-trien-20-one (2), were isolated from the whole plants of Sarcococca orientalis. Their structures were assigned by interpreting the spectroscopic data and comparing the literature. Compounds 1 and 2 exhibited a certain inhibitory effects on NO production in lipopolysaccharide (LPS)-activated BV-2 microglial cells with IC50 values of 16.88 ± 0.10 and 24.26 ± 0.30 μM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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